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Gene: SYPL2 |
Gene summary for SYPL2 |
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Gene information | Species | Human | Gene symbol | SYPL2 | Gene ID | 284612 |
Gene name | synaptophysin like 2 | |
Gene Alias | MG29 | |
Cytomap | 1p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006873 | UniProtAcc | Q5VXT5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284612 | SYPL2 | S014 | Human | Liver | HCC | 2.32e-03 | 2.18e-01 | 0.2254 |
284612 | SYPL2 | S015 | Human | Liver | HCC | 4.55e-03 | 2.89e-01 | 0.2375 |
284612 | SYPL2 | S016 | Human | Liver | HCC | 4.85e-06 | 2.79e-01 | 0.2243 |
284612 | SYPL2 | S027 | Human | Liver | HCC | 4.17e-12 | 6.43e-01 | 0.2446 |
284612 | SYPL2 | S028 | Human | Liver | HCC | 2.45e-21 | 6.89e-01 | 0.2503 |
284612 | SYPL2 | S029 | Human | Liver | HCC | 3.00e-19 | 7.39e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002176222 | Liver | HCC | substantia nigra development | 33/7958 | 44/18723 | 1.21e-05 | 1.38e-04 | 33 |
GO:003090121 | Liver | HCC | midbrain development | 54/7958 | 90/18723 | 6.04e-04 | 3.79e-03 | 54 |
GO:004885722 | Liver | HCC | neural nucleus development | 38/7958 | 64/18723 | 4.78e-03 | 2.02e-02 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SYPL2 | SNV | Missense_Mutation | c.769G>T | p.Gly257Cys | p.G257C | Q5VXT5 | protein_coding | deleterious(0.02) | benign(0.436) | TCGA-44-A479-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SYPL2 | SNV | Missense_Mutation | c.319N>A | p.Leu107Ile | p.L107I | Q5VXT5 | protein_coding | deleterious(0) | possibly_damaging(0.481) | TCGA-73-4676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |
SYPL2 | SNV | Missense_Mutation | c.722N>C | p.Gly241Ala | p.G241A | Q5VXT5 | protein_coding | tolerated(1) | benign(0.003) | TCGA-97-A4M0-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SYPL2 | SNV | Missense_Mutation | novel | c.678N>T | p.Trp226Cys | p.W226C | Q5VXT5 | protein_coding | deleterious(0) | benign(0.159) | TCGA-60-2714-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
SYPL2 | SNV | Missense_Mutation | novel | c.712C>A | p.Pro238Thr | p.P238T | Q5VXT5 | protein_coding | tolerated(0.25) | benign(0.091) | TCGA-BA-4076-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
SYPL2 | SNV | Missense_Mutation | novel | c.622T>A | p.Ser208Thr | p.S208T | Q5VXT5 | protein_coding | tolerated(0.25) | possibly_damaging(0.824) | TCGA-CR-7371-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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