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Gene: STYK1 |
Gene summary for STYK1 |
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Gene information | Species | Human | Gene symbol | STYK1 | Gene ID | 55359 |
Gene name | serine/threonine/tyrosine kinase 1 | |
Gene Alias | NOK | |
Cytomap | 12p13.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q6J9G0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55359 | STYK1 | CCI_1 | Human | Cervix | CC | 1.50e-10 | 7.46e-01 | 0.528 |
55359 | STYK1 | CCI_2 | Human | Cervix | CC | 2.16e-02 | 3.46e-01 | 0.5249 |
55359 | STYK1 | CCI_3 | Human | Cervix | CC | 3.64e-06 | 5.62e-01 | 0.516 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STYK1 | SNV | Missense_Mutation | rs147511596 | c.836G>A | p.Arg279Gln | p.R279Q | Q6J9G0 | protein_coding | tolerated(0.43) | benign(0.007) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
STYK1 | SNV | Missense_Mutation | rs537296580 | c.1096N>T | p.Arg366Cys | p.R366C | Q6J9G0 | protein_coding | deleterious(0.01) | possibly_damaging(0.533) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | novel | c.729N>T | p.Gln243His | p.Q243H | Q6J9G0 | protein_coding | tolerated(0.85) | benign(0.006) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | rs200579192 | c.632G>A | p.Arg211Gln | p.R211Q | Q6J9G0 | protein_coding | tolerated(0.51) | benign(0.223) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | novel | c.512N>C | p.Leu171Pro | p.L171P | Q6J9G0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
STYK1 | SNV | Missense_Mutation | novel | c.1022N>T | p.Arg341Ile | p.R341I | Q6J9G0 | protein_coding | deleterious(0) | possibly_damaging(0.562) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | novel | c.493N>T | p.Ile165Phe | p.I165F | Q6J9G0 | protein_coding | deleterious(0.01) | possibly_damaging(0.713) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | novel | c.200N>C | p.Val67Ala | p.V67A | Q6J9G0 | protein_coding | tolerated(0.81) | benign(0) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | rs200398907 | c.173G>A | p.Arg58His | p.R58H | Q6J9G0 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STYK1 | SNV | Missense_Mutation | rs765002535 | c.1148N>T | p.Ala383Val | p.A383V | Q6J9G0 | protein_coding | tolerated(0.06) | possibly_damaging(0.895) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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