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Gene: STRIP2 |
Gene summary for STRIP2 |
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Gene information | Species | Human | Gene symbol | STRIP2 | Gene ID | 57464 |
Gene name | striatin interacting protein 2 | |
Gene Alias | FAM40B | |
Cytomap | 7q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9ULQ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57464 | STRIP2 | ATC09 | Human | Thyroid | ATC | 1.29e-03 | 2.02e-01 | 0.2871 |
57464 | STRIP2 | ATC12 | Human | Thyroid | ATC | 5.95e-07 | 2.16e-01 | 0.34 |
57464 | STRIP2 | ATC1 | Human | Thyroid | ATC | 1.55e-03 | 2.19e-01 | 0.2878 |
57464 | STRIP2 | ATC2 | Human | Thyroid | ATC | 9.20e-14 | 8.26e-01 | 0.34 |
57464 | STRIP2 | ATC4 | Human | Thyroid | ATC | 6.40e-11 | 2.85e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260429 | Thyroid | ATC | regulation of cell morphogenesis | 171/6293 | 309/18723 | 2.36e-15 | 1.70e-13 | 171 |
GO:000836026 | Thyroid | ATC | regulation of cell shape | 91/6293 | 154/18723 | 7.33e-11 | 2.31e-09 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STRIP2 | SNV | Missense_Mutation | novel | c.2133G>T | p.Lys711Asn | p.K711N | Q9ULQ0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
STRIP2 | SNV | Missense_Mutation | c.2218C>T | p.Arg740Cys | p.R740C | Q9ULQ0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
STRIP2 | SNV | Missense_Mutation | novel | c.2366C>A | p.Pro789His | p.P789H | Q9ULQ0 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
STRIP2 | SNV | Missense_Mutation | novel | c.2449N>A | p.Glu817Lys | p.E817K | Q9ULQ0 | protein_coding | tolerated(0.05) | possibly_damaging(0.695) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STRIP2 | SNV | Missense_Mutation | novel | c.209N>C | p.Ser70Thr | p.S70T | Q9ULQ0 | protein_coding | tolerated(0.16) | probably_damaging(0.95) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STRIP2 | SNV | Missense_Mutation | rs367686911 | c.1423N>A | p.Ala475Thr | p.A475T | Q9ULQ0 | protein_coding | deleterious(0.05) | benign(0.406) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
STRIP2 | SNV | Missense_Mutation | rs375288795 | c.344G>A | p.Arg115Gln | p.R115Q | Q9ULQ0 | protein_coding | tolerated(0.89) | benign(0.001) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STRIP2 | SNV | Missense_Mutation | c.2165N>A | p.Arg722His | p.R722H | Q9ULQ0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STRIP2 | SNV | Missense_Mutation | rs756286396 | c.1541N>T | p.Pro514Leu | p.P514L | Q9ULQ0 | protein_coding | deleterious(0) | possibly_damaging(0.65) | TCGA-AP-A0LE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STRIP2 | SNV | Missense_Mutation | c.2069N>T | p.Ser690Leu | p.S690L | Q9ULQ0 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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