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Gene: ST8SIA3 |
Gene summary for ST8SIA3 |
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Gene information | Species | Human | Gene symbol | ST8SIA3 | Gene ID | 51046 |
Gene name | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 | |
Gene Alias | SIAT8C | |
Cytomap | 18q21.31 | |
Gene Type | protein-coding | GO ID | GO:0001573 | UniProtAcc | O43173 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51046 | ST8SIA3 | S014 | Human | Liver | HCC | 3.32e-18 | 7.62e-01 | 0.2254 |
51046 | ST8SIA3 | S015 | Human | Liver | HCC | 2.71e-28 | 1.07e+00 | 0.2375 |
51046 | ST8SIA3 | S016 | Human | Liver | HCC | 7.18e-31 | 8.16e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066431 | Liver | HCC | membrane lipid metabolic process | 115/7958 | 203/18723 | 3.17e-05 | 3.22e-04 | 115 |
GO:00064862 | Liver | HCC | protein glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00434132 | Liver | HCC | macromolecule glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00700852 | Liver | HCC | glycosylation | 128/7958 | 240/18723 | 4.35e-04 | 2.92e-03 | 128 |
GO:0006665 | Liver | HCC | sphingolipid metabolic process | 85/7958 | 155/18723 | 1.27e-03 | 6.92e-03 | 85 |
GO:0046467 | Liver | HCC | membrane lipid biosynthetic process | 78/7958 | 142/18723 | 1.85e-03 | 9.46e-03 | 78 |
GO:0009100 | Liver | HCC | glycoprotein metabolic process | 193/7958 | 387/18723 | 1.89e-03 | 9.62e-03 | 193 |
GO:0006664 | Liver | HCC | glycolipid metabolic process | 57/7958 | 100/18723 | 2.40e-03 | 1.17e-02 | 57 |
GO:1903509 | Liver | HCC | liposaccharide metabolic process | 57/7958 | 101/18723 | 3.25e-03 | 1.49e-02 | 57 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ST8SIA3 | SNV | Missense_Mutation | rs775252109 | c.191N>T | p.Ala64Val | p.A64V | O43173 | protein_coding | benign(0.041) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
ST8SIA3 | SNV | Missense_Mutation | c.976T>G | p.Phe326Val | p.F326V | O43173 | protein_coding | benign(0.003) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
ST8SIA3 | SNV | Missense_Mutation | novel | c.72N>G | p.Ile24Met | p.I24M | O43173 | protein_coding | probably_damaging(0.924) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ST8SIA3 | SNV | Missense_Mutation | c.562C>T | p.Arg188Cys | p.R188C | O43173 | protein_coding | probably_damaging(1) | TCGA-AX-A0IS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
ST8SIA3 | SNV | Missense_Mutation | c.344C>A | p.Ser115Tyr | p.S115Y | O43173 | protein_coding | probably_damaging(0.947) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ST8SIA3 | SNV | Missense_Mutation | c.581C>T | p.Thr194Met | p.T194M | O43173 | protein_coding | probably_damaging(0.96) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | ||
ST8SIA3 | SNV | Missense_Mutation | c.430N>G | p.Phe144Val | p.F144V | O43173 | protein_coding | benign(0.096) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ST8SIA3 | SNV | Missense_Mutation | c.980N>G | p.Asp327Gly | p.D327G | O43173 | protein_coding | benign(0.185) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ST8SIA3 | SNV | Missense_Mutation | novel | c.233C>A | p.Ser78Tyr | p.S78Y | O43173 | protein_coding | benign(0.28) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ST8SIA3 | SNV | Missense_Mutation | c.581N>T | p.Thr194Met | p.T194M | O43173 | protein_coding | probably_damaging(0.96) | TCGA-D1-A16R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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