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Gene: ST3GAL4 |
Gene summary for ST3GAL4 |
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Gene information | Species | Human | Gene symbol | ST3GAL4 | Gene ID | 6484 |
Gene name | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 | |
Gene Alias | CGS23 | |
Cytomap | 11q24.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q11206 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6484 | ST3GAL4 | LZE4T | Human | Esophagus | ESCC | 2.50e-05 | 1.58e-01 | 0.0811 |
6484 | ST3GAL4 | LZE5T | Human | Esophagus | ESCC | 6.94e-03 | 2.86e-01 | 0.0514 |
6484 | ST3GAL4 | LZE24T | Human | Esophagus | ESCC | 2.78e-04 | 7.44e-02 | 0.0596 |
6484 | ST3GAL4 | P2T-E | Human | Esophagus | ESCC | 2.86e-79 | 1.40e+00 | 0.1177 |
6484 | ST3GAL4 | P4T-E | Human | Esophagus | ESCC | 1.07e-10 | 2.77e-01 | 0.1323 |
6484 | ST3GAL4 | P5T-E | Human | Esophagus | ESCC | 9.67e-05 | 6.86e-02 | 0.1327 |
6484 | ST3GAL4 | P8T-E | Human | Esophagus | ESCC | 1.91e-23 | 5.28e-01 | 0.0889 |
6484 | ST3GAL4 | P9T-E | Human | Esophagus | ESCC | 4.59e-07 | 2.76e-01 | 0.1131 |
6484 | ST3GAL4 | P10T-E | Human | Esophagus | ESCC | 2.85e-13 | 2.39e-01 | 0.116 |
6484 | ST3GAL4 | P11T-E | Human | Esophagus | ESCC | 1.91e-31 | 9.88e-01 | 0.1426 |
6484 | ST3GAL4 | P12T-E | Human | Esophagus | ESCC | 8.65e-12 | 3.96e-01 | 0.1122 |
6484 | ST3GAL4 | P15T-E | Human | Esophagus | ESCC | 1.05e-14 | 3.26e-01 | 0.1149 |
6484 | ST3GAL4 | P16T-E | Human | Esophagus | ESCC | 3.26e-47 | 1.17e+00 | 0.1153 |
6484 | ST3GAL4 | P17T-E | Human | Esophagus | ESCC | 5.84e-04 | 3.79e-01 | 0.1278 |
6484 | ST3GAL4 | P19T-E | Human | Esophagus | ESCC | 1.38e-09 | 8.57e-01 | 0.1662 |
6484 | ST3GAL4 | P21T-E | Human | Esophagus | ESCC | 3.00e-36 | 9.39e-01 | 0.1617 |
6484 | ST3GAL4 | P22T-E | Human | Esophagus | ESCC | 5.95e-08 | 1.57e-01 | 0.1236 |
6484 | ST3GAL4 | P24T-E | Human | Esophagus | ESCC | 9.75e-18 | 4.32e-01 | 0.1287 |
6484 | ST3GAL4 | P26T-E | Human | Esophagus | ESCC | 9.48e-15 | 2.04e-01 | 0.1276 |
6484 | ST3GAL4 | P27T-E | Human | Esophagus | ESCC | 5.30e-14 | 4.61e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:001908017 | Esophagus | ESCC | viral gene expression | 80/8552 | 94/18723 | 2.04e-15 | 1.28e-13 | 80 |
GO:004578527 | Esophagus | ESCC | positive regulation of cell adhesion | 255/8552 | 437/18723 | 5.07e-08 | 9.11e-07 | 255 |
GO:00066433 | Esophagus | ESCC | membrane lipid metabolic process | 130/8552 | 203/18723 | 9.29e-08 | 1.54e-06 | 130 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:00442725 | Esophagus | ESCC | sulfur compound biosynthetic process | 96/8552 | 148/18723 | 1.86e-06 | 2.16e-05 | 96 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00464673 | Esophagus | ESCC | membrane lipid biosynthetic process | 91/8552 | 142/18723 | 7.19e-06 | 7.19e-05 | 91 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00190826 | Esophagus | ESCC | viral protein processing | 24/8552 | 29/18723 | 4.50e-05 | 3.55e-04 | 24 |
GO:00160514 | Esophagus | ESCC | carbohydrate biosynthetic process | 117/8552 | 202/18723 | 2.96e-04 | 1.79e-03 | 117 |
GO:00066642 | Esophagus | ESCC | glycolipid metabolic process | 63/8552 | 100/18723 | 3.55e-04 | 2.06e-03 | 63 |
GO:19035092 | Esophagus | ESCC | liposaccharide metabolic process | 63/8552 | 101/18723 | 5.25e-04 | 2.90e-03 | 63 |
GO:002240720 | Esophagus | ESCC | regulation of cell-cell adhesion | 239/8552 | 448/18723 | 5.88e-04 | 3.19e-03 | 239 |
GO:002240919 | Esophagus | ESCC | positive regulation of cell-cell adhesion | 155/8552 | 284/18723 | 1.50e-03 | 7.06e-03 | 155 |
GO:00302586 | Esophagus | ESCC | lipid modification | 116/8552 | 212/18723 | 4.90e-03 | 1.89e-02 | 116 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ST3GAL4 | SNV | Missense_Mutation | novel | c.891G>T | p.Glu297Asp | p.E297D | Q11206 | protein_coding | tolerated(0.76) | possibly_damaging(0.831) | TCGA-55-7281-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ST3GAL4 | SNV | Missense_Mutation | c.767N>C | p.Lys256Thr | p.K256T | Q11206 | protein_coding | deleterious(0.05) | benign(0.007) | TCGA-18-3421-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ST3GAL4 | SNV | Missense_Mutation | c.339N>C | p.Gln113His | p.Q113H | Q11206 | protein_coding | tolerated(0.15) | possibly_damaging(0.663) | TCGA-60-2709-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ST3GAL4 | deletion | Frame_Shift_Del | c.351delN | p.Arg118AlafsTer30 | p.R118Afs*30 | Q11206 | protein_coding | TCGA-97-7938-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ST3GAL4 | SNV | Missense_Mutation | novel | c.154N>A | p.Glu52Lys | p.E52K | Q11206 | protein_coding | tolerated(0.75) | benign(0.031) | TCGA-CV-6441-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
ST3GAL4 | SNV | Missense_Mutation | c.496N>T | p.Arg166Cys | p.R166C | Q11206 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ST3GAL4 | SNV | Missense_Mutation | rs11559148 | c.79C>T | p.Arg27Trp | p.R27W | Q11206 | protein_coding | tolerated_low_confidence(0.06) | possibly_damaging(0.65) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR |
ST3GAL4 | SNV | Missense_Mutation | rs201384951 | c.757N>T | p.Arg253Trp | p.R253W | Q11206 | protein_coding | deleterious(0.03) | possibly_damaging(0.863) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
ST3GAL4 | SNV | Missense_Mutation | c.608N>C | p.Ile203Thr | p.I203T | Q11206 | protein_coding | tolerated(0.08) | possibly_damaging(0.723) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR | |
ST3GAL4 | SNV | Missense_Mutation | novel | c.949N>A | p.Ala317Thr | p.A317T | Q11206 | protein_coding | tolerated(0.34) | possibly_damaging(0.902) | TCGA-SW-A7EA-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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