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Gene: SSFA2 |
Gene summary for SSFA2 |
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Gene information | Species | Human | Gene symbol | SSFA2 | Gene ID | 6744 |
Gene name | ITPR interacting domain containing 2 | |
Gene Alias | CS-1 | |
Cytomap | 2q31.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | P28290 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6744 | SSFA2 | GSM4909296 | Human | Breast | IDC | 6.79e-05 | -1.61e-01 | 0.1524 |
6744 | SSFA2 | GSM4909297 | Human | Breast | IDC | 7.73e-03 | -1.13e-01 | 0.1517 |
6744 | SSFA2 | GSM4909299 | Human | Breast | IDC | 4.14e-05 | 3.51e-01 | 0.035 |
6744 | SSFA2 | GSM4909307 | Human | Breast | IDC | 1.54e-20 | 6.89e-01 | 0.1569 |
6744 | SSFA2 | GSM4909308 | Human | Breast | IDC | 2.92e-50 | 8.73e-01 | 0.158 |
6744 | SSFA2 | GSM4909311 | Human | Breast | IDC | 2.45e-07 | -1.65e-01 | 0.1534 |
6744 | SSFA2 | GSM4909313 | Human | Breast | IDC | 1.03e-02 | 2.74e-01 | 0.0391 |
6744 | SSFA2 | GSM4909319 | Human | Breast | IDC | 1.04e-08 | -1.95e-01 | 0.1563 |
6744 | SSFA2 | GSM4909321 | Human | Breast | IDC | 2.13e-05 | -1.65e-01 | 0.1559 |
6744 | SSFA2 | M5 | Human | Breast | IDC | 6.05e-08 | 7.13e-01 | 0.1598 |
6744 | SSFA2 | P1 | Human | Breast | IDC | 4.22e-02 | -1.26e-01 | 0.1527 |
6744 | SSFA2 | DCIS2 | Human | Breast | DCIS | 3.10e-65 | 5.07e-01 | 0.0085 |
6744 | SSFA2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.47e-34 | -6.13e-01 | 0.0155 |
6744 | SSFA2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.51e-20 | -6.13e-01 | -0.1808 |
6744 | SSFA2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.69e-05 | -6.13e-01 | 0.0216 |
6744 | SSFA2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.06e-16 | -6.13e-01 | -0.0811 |
6744 | SSFA2 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.25e-24 | -6.13e-01 | -0.1088 |
6744 | SSFA2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.11e-36 | -6.13e-01 | -0.1954 |
6744 | SSFA2 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.73e-03 | -6.13e-01 | -0.2602 |
6744 | SSFA2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.67e-04 | -6.13e-01 | -0.2196 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SSFA2 | SNV | Missense_Mutation | novel | c.1116N>T | p.Glu372Asp | p.E372D | P28290 | protein_coding | tolerated(0.48) | benign(0.001) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SSFA2 | SNV | Missense_Mutation | rs778799913 | c.2375N>A | p.Gly792Asp | p.G792D | P28290 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SSFA2 | SNV | Missense_Mutation | c.2995N>G | p.Phe999Val | p.F999V | P28290 | protein_coding | deleterious(0.05) | benign(0.053) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSFA2 | SNV | Missense_Mutation | c.3752N>T | p.Ala1251Val | p.A1251V | P28290 | protein_coding | tolerated(0.15) | benign(0.32) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SSFA2 | SNV | Missense_Mutation | rs760899439 | c.3707N>A | p.Arg1236Gln | p.R1236Q | P28290 | protein_coding | tolerated(0.17) | possibly_damaging(0.889) | TCGA-D5-5537-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SSFA2 | SNV | Missense_Mutation | c.1123N>C | p.Asp375His | p.D375H | P28290 | protein_coding | tolerated(0.08) | benign(0.255) | TCGA-DM-A1DB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SSFA2 | SNV | Missense_Mutation | c.2741N>A | p.Arg914Gln | p.R914Q | P28290 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SSFA2 | SNV | Missense_Mutation | c.2741N>A | p.Arg914Gln | p.R914Q | P28290 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-3999-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unspecific | PD | ||
SSFA2 | SNV | Missense_Mutation | c.2932N>G | p.Leu978Val | p.L978V | P28290 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EI-6506-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSFA2 | SNV | Missense_Mutation | novel | c.231N>T | p.Lys77Asn | p.K77N | P28290 | protein_coding | tolerated(0.18) | possibly_damaging(0.836) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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