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Gene: SRGAP2 |
Gene summary for SRGAP2 |
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Gene information | Species | Human | Gene symbol | SRGAP2 | Gene ID | 23380 |
Gene name | SLIT-ROBO Rho GTPase activating protein 2 | |
Gene Alias | ARHGAP34 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | B4DFE5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23380 | SRGAP2 | CCI_1 | Human | Cervix | CC | 3.88e-04 | 7.35e-01 | 0.528 |
23380 | SRGAP2 | CCI_2 | Human | Cervix | CC | 2.29e-02 | 5.46e-01 | 0.5249 |
23380 | SRGAP2 | CCI_3 | Human | Cervix | CC | 4.86e-06 | 5.62e-01 | 0.516 |
23380 | SRGAP2 | S014 | Human | Liver | HCC | 1.22e-15 | 6.20e-01 | 0.2254 |
23380 | SRGAP2 | S015 | Human | Liver | HCC | 5.55e-06 | 3.71e-01 | 0.2375 |
23380 | SRGAP2 | S016 | Human | Liver | HCC | 4.32e-15 | 5.27e-01 | 0.2243 |
23380 | SRGAP2 | S028 | Human | Liver | HCC | 1.23e-03 | 3.01e-01 | 0.2503 |
23380 | SRGAP2 | S029 | Human | Liver | HCC | 4.37e-06 | 3.50e-01 | 0.2581 |
23380 | SRGAP2 | PTC04 | Human | Thyroid | PTC | 5.43e-04 | 1.13e-01 | 0.1927 |
23380 | SRGAP2 | PTC05 | Human | Thyroid | PTC | 2.87e-07 | 2.80e-01 | 0.2065 |
23380 | SRGAP2 | PTC06 | Human | Thyroid | PTC | 3.15e-09 | 2.69e-01 | 0.2057 |
23380 | SRGAP2 | PTC07 | Human | Thyroid | PTC | 4.67e-07 | 1.60e-01 | 0.2044 |
23380 | SRGAP2 | ATC09 | Human | Thyroid | ATC | 4.52e-12 | 3.47e-01 | 0.2871 |
23380 | SRGAP2 | ATC12 | Human | Thyroid | ATC | 3.77e-15 | 2.91e-01 | 0.34 |
23380 | SRGAP2 | ATC13 | Human | Thyroid | ATC | 1.45e-24 | 3.44e-01 | 0.34 |
23380 | SRGAP2 | ATC1 | Human | Thyroid | ATC | 3.37e-11 | 3.45e-01 | 0.2878 |
23380 | SRGAP2 | ATC2 | Human | Thyroid | ATC | 3.39e-19 | 9.19e-01 | 0.34 |
23380 | SRGAP2 | ATC4 | Human | Thyroid | ATC | 8.26e-18 | 3.46e-01 | 0.34 |
23380 | SRGAP2 | ATC5 | Human | Thyroid | ATC | 1.50e-26 | 3.85e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:00975817 | Cervix | CC | lamellipodium organization | 31/2311 | 90/18723 | 4.57e-08 | 2.76e-06 | 31 |
GO:00300325 | Cervix | CC | lamellipodium assembly | 26/2311 | 72/18723 | 1.87e-07 | 8.48e-06 | 26 |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:00344469 | Cervix | CC | substrate adhesion-dependent cell spreading | 32/2311 | 108/18723 | 1.36e-06 | 4.55e-05 | 32 |
GO:00609965 | Cervix | CC | dendritic spine development | 28/2311 | 99/18723 | 1.61e-05 | 3.15e-04 | 28 |
GO:00512713 | Cervix | CC | negative regulation of cellular component movement | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
GO:00400133 | Cervix | CC | negative regulation of locomotion | 76/2311 | 391/18723 | 3.47e-05 | 5.60e-04 | 76 |
GO:20001463 | Cervix | CC | negative regulation of cell motility | 71/2311 | 359/18723 | 3.47e-05 | 5.60e-04 | 71 |
GO:00303363 | Cervix | CC | negative regulation of cell migration | 68/2311 | 344/18723 | 5.11e-05 | 7.70e-04 | 68 |
GO:00435476 | Cervix | CC | positive regulation of GTPase activity | 53/2311 | 255/18723 | 8.72e-05 | 1.16e-03 | 53 |
GO:00219873 | Cervix | CC | cerebral cortex development | 25/2311 | 114/18723 | 2.81e-03 | 1.88e-02 | 25 |
GO:00309003 | Cervix | CC | forebrain development | 64/2311 | 379/18723 | 5.53e-03 | 3.19e-02 | 64 |
GO:00215433 | Cervix | CC | pallium development | 32/2311 | 169/18723 | 8.73e-03 | 4.48e-02 | 32 |
GO:00510143 | Cervix | CC | actin filament severing | 6/2311 | 16/18723 | 9.35e-03 | 4.66e-02 | 6 |
GO:009758121 | Liver | HCC | lamellipodium organization | 58/7958 | 90/18723 | 2.16e-05 | 2.30e-04 | 58 |
GO:003444622 | Liver | HCC | substrate adhesion-dependent cell spreading | 67/7958 | 108/18723 | 3.24e-05 | 3.28e-04 | 67 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043609 | Cervix | CC | Axon guidance | 47/1267 | 182/8465 | 8.13e-05 | 5.38e-04 | 3.18e-04 | 47 |
hsa0436012 | Cervix | CC | Axon guidance | 47/1267 | 182/8465 | 8.13e-05 | 5.38e-04 | 3.18e-04 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRGAP2 | SNV | Missense_Mutation | rs769054196 | c.2347G>A | p.Val783Met | p.V783M | protein_coding | tolerated(0.13) | possibly_damaging(0.77) | TCGA-F4-6805-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
SRGAP2 | SNV | Missense_Mutation | rs568447589 | c.2804N>A | p.Arg935Gln | p.R935Q | protein_coding | deleterious_low_confidence(0.02) | benign(0.025) | TCGA-QG-A5YV-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | CR | |
SRGAP2 | SNV | Missense_Mutation | novel | c.383T>G | p.Phe128Cys | p.F128C | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SRGAP2 | insertion | Frame_Shift_Ins | novel | c.2466_2467insG | p.His825SerfsTer29 | p.H825Sfs*29 | protein_coding | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
SRGAP2 | deletion | Frame_Shift_Del | c.3182delN | p.Pro1062HisfsTer13 | p.P1062Hfs*13 | protein_coding | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||||
SRGAP2 | insertion | Frame_Shift_Ins | novel | c.3181_3182insC | p.Gln1063ThrfsTer4 | p.Q1063Tfs*4 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
SRGAP2 | SNV | Missense_Mutation | rs782774981 | c.2440N>A | p.Ala814Thr | p.A814T | protein_coding | tolerated(0.21) | benign(0.005) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SRGAP2 | SNV | Missense_Mutation | novel | c.350N>T | p.Ser117Ile | p.S117I | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SRGAP2 | SNV | Missense_Mutation | rs376951626 | c.614N>A | p.Arg205His | p.R205H | protein_coding | tolerated(0.05) | possibly_damaging(0.893) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SRGAP2 | SNV | Missense_Mutation | novel | c.1217N>C | p.Asp406Ala | p.D406A | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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