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Gene: SNX7 |
Gene summary for SNX7 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SNX7 | Gene ID | 51375 |
Gene name | sorting nexin 7 | |
Gene Alias | SNX7 | |
Cytomap | 1p21.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9UNH6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51375 | SNX7 | LZE20T | Human | Esophagus | ESCC | 8.99e-03 | 6.10e-02 | 0.0662 |
51375 | SNX7 | LZE24T | Human | Esophagus | ESCC | 2.46e-05 | 4.63e-02 | 0.0596 |
51375 | SNX7 | P1T-E | Human | Esophagus | ESCC | 1.64e-02 | 1.19e-01 | 0.0875 |
51375 | SNX7 | P2T-E | Human | Esophagus | ESCC | 1.06e-18 | 3.64e-01 | 0.1177 |
51375 | SNX7 | P4T-E | Human | Esophagus | ESCC | 7.69e-14 | 2.54e-01 | 0.1323 |
51375 | SNX7 | P5T-E | Human | Esophagus | ESCC | 1.55e-15 | 2.97e-01 | 0.1327 |
51375 | SNX7 | P8T-E | Human | Esophagus | ESCC | 6.79e-20 | 3.73e-01 | 0.0889 |
51375 | SNX7 | P9T-E | Human | Esophagus | ESCC | 8.98e-11 | 1.99e-01 | 0.1131 |
51375 | SNX7 | P10T-E | Human | Esophagus | ESCC | 4.52e-11 | 8.13e-02 | 0.116 |
51375 | SNX7 | P11T-E | Human | Esophagus | ESCC | 4.62e-11 | 2.86e-01 | 0.1426 |
51375 | SNX7 | P12T-E | Human | Esophagus | ESCC | 1.82e-14 | 2.51e-01 | 0.1122 |
51375 | SNX7 | P16T-E | Human | Esophagus | ESCC | 1.07e-02 | -4.53e-03 | 0.1153 |
51375 | SNX7 | P19T-E | Human | Esophagus | ESCC | 1.06e-08 | 6.18e-01 | 0.1662 |
51375 | SNX7 | P20T-E | Human | Esophagus | ESCC | 1.46e-11 | 9.89e-02 | 0.1124 |
51375 | SNX7 | P22T-E | Human | Esophagus | ESCC | 1.38e-06 | 1.06e-01 | 0.1236 |
51375 | SNX7 | P23T-E | Human | Esophagus | ESCC | 2.17e-19 | 5.06e-01 | 0.108 |
51375 | SNX7 | P24T-E | Human | Esophagus | ESCC | 1.16e-10 | 2.02e-01 | 0.1287 |
51375 | SNX7 | P26T-E | Human | Esophagus | ESCC | 2.38e-17 | 2.32e-01 | 0.1276 |
51375 | SNX7 | P27T-E | Human | Esophagus | ESCC | 2.46e-13 | 5.31e-02 | 0.1055 |
51375 | SNX7 | P30T-E | Human | Esophagus | ESCC | 1.30e-09 | 3.12e-01 | 0.137 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX7 | SNV | Missense_Mutation | rs371219132 | c.344N>T | p.Thr115Met | p.T115M | Q9UNH6 | protein_coding | tolerated(0.07) | probably_damaging(0.959) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNX7 | SNV | Missense_Mutation | novel | c.759N>T | p.Met253Ile | p.M253I | Q9UNH6 | protein_coding | tolerated(0.37) | benign(0.061) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SNX7 | SNV | Missense_Mutation | novel | c.793N>C | p.Asn265His | p.N265H | Q9UNH6 | protein_coding | deleterious(0.03) | possibly_damaging(0.854) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SNX7 | SNV | Missense_Mutation | novel | c.818G>T | p.Arg273Ile | p.R273I | Q9UNH6 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SNX7 | insertion | Frame_Shift_Ins | rs770251307 | c.1047_1048insA | p.Arg351LysfsTer14 | p.R351Kfs*14 | Q9UNH6 | protein_coding | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SNX7 | SNV | Missense_Mutation | novel | c.633N>T | p.Gln211His | p.Q211H | Q9UNH6 | protein_coding | deleterious(0) | benign(0.273) | TCGA-XR-A8TF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SNX7 | SNV | Missense_Mutation | c.451N>C | p.Ala151Pro | p.A151P | Q9UNH6 | protein_coding | deleterious(0.02) | possibly_damaging(0.826) | TCGA-05-5428-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
SNX7 | SNV | Missense_Mutation | c.1092N>C | p.Glu364Asp | p.E364D | Q9UNH6 | protein_coding | tolerated(0.21) | benign(0.036) | TCGA-44-7667-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SNX7 | SNV | Missense_Mutation | c.1222N>T | p.Asp408Tyr | p.D408Y | Q9UNH6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-44-7671-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SNX7 | SNV | Missense_Mutation | novel | c.482N>T | p.Pro161Leu | p.P161L | Q9UNH6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-86-8673-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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