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Gene: SNRNP35 |
Gene summary for SNRNP35 |
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Gene information | Species | Human | Gene symbol | SNRNP35 | Gene ID | 11066 |
Gene name | small nuclear ribonucleoprotein U11/U12 subunit 35 | |
Gene Alias | HM-1 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | A0A024RBU2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11066 | SNRNP35 | LZE4T | Human | Esophagus | ESCC | 1.47e-03 | 1.13e-01 | 0.0811 |
11066 | SNRNP35 | LZE5T | Human | Esophagus | ESCC | 4.10e-03 | 1.82e-01 | 0.0514 |
11066 | SNRNP35 | LZE7T | Human | Esophagus | ESCC | 4.61e-05 | 2.98e-01 | 0.0667 |
11066 | SNRNP35 | LZE8T | Human | Esophagus | ESCC | 1.17e-02 | 6.34e-02 | 0.067 |
11066 | SNRNP35 | LZE20T | Human | Esophagus | ESCC | 1.10e-04 | 1.60e-01 | 0.0662 |
11066 | SNRNP35 | LZE22T | Human | Esophagus | ESCC | 3.16e-02 | 1.53e-01 | 0.068 |
11066 | SNRNP35 | LZE24T | Human | Esophagus | ESCC | 1.30e-10 | 2.73e-01 | 0.0596 |
11066 | SNRNP35 | LZE21T | Human | Esophagus | ESCC | 7.48e-03 | 1.84e-01 | 0.0655 |
11066 | SNRNP35 | LZE6T | Human | Esophagus | ESCC | 6.23e-09 | 3.13e-01 | 0.0845 |
11066 | SNRNP35 | P2T-E | Human | Esophagus | ESCC | 3.81e-34 | 5.69e-01 | 0.1177 |
11066 | SNRNP35 | P4T-E | Human | Esophagus | ESCC | 1.15e-19 | 3.84e-01 | 0.1323 |
11066 | SNRNP35 | P5T-E | Human | Esophagus | ESCC | 3.53e-14 | 2.13e-01 | 0.1327 |
11066 | SNRNP35 | P8T-E | Human | Esophagus | ESCC | 3.77e-18 | 3.07e-01 | 0.0889 |
11066 | SNRNP35 | P9T-E | Human | Esophagus | ESCC | 4.04e-11 | 2.27e-01 | 0.1131 |
11066 | SNRNP35 | P10T-E | Human | Esophagus | ESCC | 2.18e-21 | 4.50e-01 | 0.116 |
11066 | SNRNP35 | P11T-E | Human | Esophagus | ESCC | 6.46e-10 | 3.33e-01 | 0.1426 |
11066 | SNRNP35 | P12T-E | Human | Esophagus | ESCC | 8.82e-20 | 3.05e-01 | 0.1122 |
11066 | SNRNP35 | P15T-E | Human | Esophagus | ESCC | 1.52e-14 | 2.41e-01 | 0.1149 |
11066 | SNRNP35 | P16T-E | Human | Esophagus | ESCC | 7.76e-16 | 3.12e-01 | 0.1153 |
11066 | SNRNP35 | P17T-E | Human | Esophagus | ESCC | 9.31e-06 | 3.03e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000037512 | Liver | Cirrhotic | RNA splicing, via transesterification reactions | 175/4634 | 324/18723 | 5.95e-30 | 7.47e-27 | 175 |
GO:000037712 | Liver | Cirrhotic | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:000039812 | Liver | Cirrhotic | mRNA splicing, via spliceosome | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000039822 | Liver | HCC | mRNA splicing, via spliceosome | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:000037519 | Oral cavity | OSCC | RNA splicing, via transesterification reactions | 225/7305 | 324/18723 | 5.20e-29 | 2.99e-26 | 225 |
GO:000037719 | Oral cavity | OSCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:000039819 | Oral cavity | OSCC | mRNA splicing, via spliceosome | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:0008380112 | Skin | cSCC | RNA splicing | 263/4864 | 434/18723 | 2.45e-53 | 5.13e-50 | 263 |
GO:0000375112 | Skin | cSCC | RNA splicing, via transesterification reactions | 201/4864 | 324/18723 | 4.07e-43 | 5.10e-40 | 201 |
GO:0000377112 | Skin | cSCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 197/4864 | 320/18723 | 1.45e-41 | 1.14e-38 | 197 |
GO:0000398112 | Skin | cSCC | mRNA splicing, via spliceosome | 197/4864 | 320/18723 | 1.45e-41 | 1.14e-38 | 197 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNRNP35 | SNV | Missense_Mutation | novel | c.372N>T | p.Gln124His | p.Q124H | Q16560 | protein_coding | tolerated(0.17) | possibly_damaging(0.892) | TCGA-22-1005-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SNRNP35 | SNV | Missense_Mutation | novel | c.388G>T | p.Asp130Tyr | p.D130Y | Q16560 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CV-A6JE-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SNRNP35 | SNV | Missense_Mutation | c.287N>T | p.Ser96Leu | p.S96L | Q16560 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SNRNP35 | insertion | Frame_Shift_Ins | novel | c.408_409insTCCTTTAATTTGTC | p.Leu137SerfsTer27 | p.L137Sfs*27 | Q16560 | protein_coding | TCGA-HD-8634-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SNRNP35 | SNV | Missense_Mutation | rs867638854 | c.323G>A | p.Arg108His | p.R108H | Q16560 | protein_coding | tolerated(0.09) | benign(0.11) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
SNRNP35 | deletion | Frame_Shift_Del | c.453delN | p.Lys153ArgfsTer6 | p.K153Rfs*6 | Q16560 | protein_coding | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
SNRNP35 | deletion | Frame_Shift_Del | c.453delN | p.Lys153ArgfsTer6 | p.K153Rfs*6 | Q16560 | protein_coding | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |||
SNRNP35 | SNV | Missense_Mutation | rs371556636 | c.557G>A | p.Arg186Gln | p.R186Q | Q16560 | protein_coding | tolerated(0.59) | benign(0.114) | TCGA-DJ-A1QH-01 | Thyroid | thyroid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SNRNP35 | insertion | Frame_Shift_Ins | novel | c.408_409insTCCTTTAATTTGTC | p.Leu137SerfsTer27 | p.L137Sfs*27 | Q16560 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
SNRNP35 | insertion | Frame_Shift_Ins | novel | c.437_438insTCTGCAAGTTT | p.Gly147LeufsTer4 | p.G147Lfs*4 | Q16560 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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