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Gene: SMOC2 |
Gene summary for SMOC2 |
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Gene information | Species | Human | Gene symbol | SMOC2 | Gene ID | 64094 |
Gene name | SPARC related modular calcium binding 2 | |
Gene Alias | DTDP1 | |
Cytomap | 6q27 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q9H3U7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64094 | SMOC2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.22e-02 | -5.14e-01 | -0.1808 |
64094 | SMOC2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.73e-08 | -7.37e-01 | -0.0811 |
64094 | SMOC2 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.30e-13 | -7.05e-01 | -0.1088 |
64094 | SMOC2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.44e-10 | -5.77e-01 | -0.1954 |
64094 | SMOC2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.01e-02 | -1.29e-01 | -0.2196 |
64094 | SMOC2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.19e-06 | -7.33e-01 | -0.1526 |
64094 | SMOC2 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.07e-04 | -4.85e-01 | -0.1001 |
64094 | SMOC2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.18e-08 | -5.14e-01 | -0.059 |
64094 | SMOC2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.62e-04 | -7.64e-01 | -0.2061 |
64094 | SMOC2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.31e-08 | 8.99e-01 | 0.096 |
64094 | SMOC2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 7.97e-04 | 1.34e+00 | 0.0446 |
64094 | SMOC2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.81e-05 | 1.14e+00 | 0.0528 |
64094 | SMOC2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.04e-06 | 1.95e+00 | 0.0131 |
64094 | SMOC2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.39e-17 | -7.15e-01 | 0.0674 |
64094 | SMOC2 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.37e-03 | 1.25e+00 | 0.0397 |
64094 | SMOC2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.43e-54 | 1.88e+00 | 0.294 |
64094 | SMOC2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.44e-12 | 2.53e+00 | 0.3487 |
64094 | SMOC2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.67e-02 | 8.59e-01 | 0.281 |
64094 | SMOC2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.35e-06 | 8.57e-01 | 0.3859 |
64094 | SMOC2 | F007 | Human | Colorectum | FAP | 1.04e-02 | -5.19e-01 | 0.1176 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
GO:2000278 | Colorectum | AD | regulation of DNA biosynthetic process | 41/3918 | 106/18723 | 2.17e-05 | 4.33e-04 | 41 |
GO:0001667 | Colorectum | AD | ameboidal-type cell migration | 137/3918 | 475/18723 | 2.17e-05 | 4.33e-04 | 137 |
GO:2000573 | Colorectum | AD | positive regulation of DNA biosynthetic process | 28/3918 | 66/18723 | 6.35e-05 | 1.05e-03 | 28 |
GO:0090132 | Colorectum | AD | epithelium migration | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0010632 | Colorectum | AD | regulation of epithelial cell migration | 88/3918 | 292/18723 | 1.19e-04 | 1.75e-03 | 88 |
GO:0010631 | Colorectum | AD | epithelial cell migration | 104/3918 | 357/18723 | 1.33e-04 | 1.90e-03 | 104 |
GO:0090130 | Colorectum | AD | tissue migration | 105/3918 | 365/18723 | 2.10e-04 | 2.77e-03 | 105 |
GO:0010634 | Colorectum | AD | positive regulation of epithelial cell migration | 56/3918 | 176/18723 | 4.51e-04 | 5.03e-03 | 56 |
GO:0071897 | Colorectum | AD | DNA biosynthetic process | 55/3918 | 180/18723 | 1.46e-03 | 1.24e-02 | 55 |
GO:0043542 | Colorectum | AD | endothelial cell migration | 78/3918 | 279/18723 | 2.97e-03 | 2.22e-02 | 78 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:2001028 | Colorectum | AD | positive regulation of endothelial cell chemotaxis | 8/3918 | 15/18723 | 5.67e-03 | 3.64e-02 | 8 |
GO:0045931 | Colorectum | AD | positive regulation of mitotic cell cycle | 37/3918 | 121/18723 | 7.88e-03 | 4.73e-02 | 37 |
GO:0010595 | Colorectum | AD | positive regulation of endothelial cell migration | 40/3918 | 133/18723 | 8.01e-03 | 4.73e-02 | 40 |
GO:00420601 | Colorectum | SER | wound healing | 97/2897 | 422/18723 | 2.69e-05 | 7.30e-04 | 97 |
GO:20002781 | Colorectum | SER | regulation of DNA biosynthetic process | 33/2897 | 106/18723 | 3.83e-05 | 9.82e-04 | 33 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMOC2 | SNV | Missense_Mutation | rs373406001 | c.400N>A | p.Val134Ile | p.V134I | Q9H3U7 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
SMOC2 | SNV | Missense_Mutation | novel | c.337N>C | p.Cys113Arg | p.C113R | Q9H3U7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMOC2 | SNV | Missense_Mutation | novel | c.247N>C | p.Asn83His | p.N83H | Q9H3U7 | protein_coding | tolerated(0.35) | possibly_damaging(0.739) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SMOC2 | SNV | Missense_Mutation | novel | c.455G>A | p.Arg152Gln | p.R152Q | Q9H3U7 | protein_coding | tolerated(0.6) | benign(0.259) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMOC2 | SNV | Missense_Mutation | novel | c.1133N>C | p.Ile378Thr | p.I378T | Q9H3U7 | protein_coding | deleterious(0) | possibly_damaging(0.447) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMOC2 | SNV | Missense_Mutation | rs551280549 | c.760G>A | p.Gly254Ser | p.G254S | Q9H3U7 | protein_coding | deleterious(0.01) | possibly_damaging(0.8) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMOC2 | SNV | Missense_Mutation | rs765267119 | c.277N>A | p.Glu93Lys | p.E93K | Q9H3U7 | protein_coding | deleterious(0.01) | probably_damaging(0.943) | TCGA-DD-A73E-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SMOC2 | SNV | Missense_Mutation | novel | c.95N>C | p.Val32Ala | p.V32A | Q9H3U7 | protein_coding | tolerated(0.12) | probably_damaging(0.968) | TCGA-DD-AADO-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SMOC2 | SNV | Missense_Mutation | novel | c.703N>A | p.Leu235Met | p.L235M | Q9H3U7 | protein_coding | deleterious(0.01) | possibly_damaging(0.608) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SMOC2 | SNV | Missense_Mutation | c.884N>A | p.Thr295Lys | p.T295K | Q9H3U7 | protein_coding | tolerated(0.15) | benign(0.182) | TCGA-73-4659-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | alimta | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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