![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SMNDC1 |
Gene summary for SMNDC1 |
![]() |
Gene information | Species | Human | Gene symbol | SMNDC1 | Gene ID | 10285 |
Gene name | survival motor neuron domain containing 1 | |
Gene Alias | SMNR | |
Cytomap | 10q25.2 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | O75940 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10285 | SMNDC1 | LZE2T | Human | Esophagus | ESCC | 3.41e-05 | 5.88e-01 | 0.082 |
10285 | SMNDC1 | LZE4T | Human | Esophagus | ESCC | 9.17e-11 | 3.63e-01 | 0.0811 |
10285 | SMNDC1 | LZE7T | Human | Esophagus | ESCC | 1.61e-09 | 1.38e-01 | 0.0667 |
10285 | SMNDC1 | LZE8T | Human | Esophagus | ESCC | 3.01e-04 | 2.42e-01 | 0.067 |
10285 | SMNDC1 | LZE20T | Human | Esophagus | ESCC | 1.86e-11 | 2.26e-01 | 0.0662 |
10285 | SMNDC1 | LZE22D1 | Human | Esophagus | HGIN | 4.36e-02 | -8.60e-02 | 0.0595 |
10285 | SMNDC1 | LZE22T | Human | Esophagus | ESCC | 1.31e-08 | 3.33e-01 | 0.068 |
10285 | SMNDC1 | LZE24T | Human | Esophagus | ESCC | 8.33e-20 | 6.30e-01 | 0.0596 |
10285 | SMNDC1 | LZE6T | Human | Esophagus | ESCC | 2.19e-08 | 3.37e-01 | 0.0845 |
10285 | SMNDC1 | P1T-E | Human | Esophagus | ESCC | 1.43e-02 | 5.46e-01 | 0.0875 |
10285 | SMNDC1 | P2T-E | Human | Esophagus | ESCC | 5.02e-41 | 8.37e-01 | 0.1177 |
10285 | SMNDC1 | P4T-E | Human | Esophagus | ESCC | 2.93e-44 | 1.07e+00 | 0.1323 |
10285 | SMNDC1 | P5T-E | Human | Esophagus | ESCC | 4.40e-40 | 9.97e-01 | 0.1327 |
10285 | SMNDC1 | P8T-E | Human | Esophagus | ESCC | 1.26e-28 | 5.49e-01 | 0.0889 |
10285 | SMNDC1 | P9T-E | Human | Esophagus | ESCC | 4.83e-08 | 2.39e-01 | 0.1131 |
10285 | SMNDC1 | P10T-E | Human | Esophagus | ESCC | 1.90e-15 | 2.92e-01 | 0.116 |
10285 | SMNDC1 | P11T-E | Human | Esophagus | ESCC | 1.04e-15 | 6.45e-01 | 0.1426 |
10285 | SMNDC1 | P12T-E | Human | Esophagus | ESCC | 2.24e-37 | 8.81e-01 | 0.1122 |
10285 | SMNDC1 | P15T-E | Human | Esophagus | ESCC | 5.75e-27 | 6.98e-01 | 0.1149 |
10285 | SMNDC1 | P16T-E | Human | Esophagus | ESCC | 6.51e-44 | 9.03e-01 | 0.1153 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:000037520 | Esophagus | HGIN | RNA splicing, via transesterification reactions | 115/2587 | 324/18723 | 3.16e-23 | 3.80e-20 | 115 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000037512 | Liver | Cirrhotic | RNA splicing, via transesterification reactions | 175/4634 | 324/18723 | 5.95e-30 | 7.47e-27 | 175 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:000037519 | Oral cavity | OSCC | RNA splicing, via transesterification reactions | 225/7305 | 324/18723 | 5.20e-29 | 2.99e-26 | 225 |
GO:0008380112 | Skin | cSCC | RNA splicing | 263/4864 | 434/18723 | 2.45e-53 | 5.13e-50 | 263 |
GO:0000375112 | Skin | cSCC | RNA splicing, via transesterification reactions | 201/4864 | 324/18723 | 4.07e-43 | 5.10e-40 | 201 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMNDC1 | SNV | Missense_Mutation | rs763744840 | c.170N>T | p.Thr57Met | p.T57M | O75940 | protein_coding | tolerated(0.1) | possibly_damaging(0.446) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
SMNDC1 | SNV | Missense_Mutation | c.310N>A | p.Ala104Thr | p.A104T | O75940 | protein_coding | deleterious(0.05) | benign(0.305) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR | |
SMNDC1 | SNV | Missense_Mutation | novel | c.314C>T | p.Ala105Val | p.A105V | O75940 | protein_coding | tolerated(0.11) | benign(0.031) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |