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Gene: SLX4IP |
Gene summary for SLX4IP |
Gene summary. |
Gene information | Species | Human | Gene symbol | SLX4IP | Gene ID | 128710 |
Gene name | SLX4 interacting protein | |
Gene Alias | C20orf94 | |
Cytomap | 20p12.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q5VYV7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
128710 | SLX4IP | CCI_2 | Human | Cervix | CC | 6.81e-10 | 8.06e-01 | 0.5249 |
128710 | SLX4IP | CCI_3 | Human | Cervix | CC | 2.87e-05 | 5.84e-01 | 0.516 |
128710 | SLX4IP | LZE4T | Human | Esophagus | ESCC | 2.61e-08 | 2.84e-01 | 0.0811 |
128710 | SLX4IP | LZE7T | Human | Esophagus | ESCC | 1.28e-02 | 2.26e-01 | 0.0667 |
128710 | SLX4IP | LZE24T | Human | Esophagus | ESCC | 7.59e-05 | 1.59e-01 | 0.0596 |
128710 | SLX4IP | P2T-E | Human | Esophagus | ESCC | 2.65e-20 | 2.60e-01 | 0.1177 |
128710 | SLX4IP | P4T-E | Human | Esophagus | ESCC | 1.13e-10 | 2.74e-01 | 0.1323 |
128710 | SLX4IP | P5T-E | Human | Esophagus | ESCC | 1.74e-16 | 1.60e-01 | 0.1327 |
128710 | SLX4IP | P8T-E | Human | Esophagus | ESCC | 8.97e-18 | 1.21e-01 | 0.0889 |
128710 | SLX4IP | P9T-E | Human | Esophagus | ESCC | 1.93e-02 | 1.30e-01 | 0.1131 |
128710 | SLX4IP | P10T-E | Human | Esophagus | ESCC | 2.96e-20 | 2.88e-01 | 0.116 |
128710 | SLX4IP | P11T-E | Human | Esophagus | ESCC | 1.89e-06 | 2.61e-01 | 0.1426 |
128710 | SLX4IP | P12T-E | Human | Esophagus | ESCC | 1.21e-12 | 2.58e-01 | 0.1122 |
128710 | SLX4IP | P15T-E | Human | Esophagus | ESCC | 2.72e-10 | 2.53e-01 | 0.1149 |
128710 | SLX4IP | P16T-E | Human | Esophagus | ESCC | 2.58e-29 | 3.31e-01 | 0.1153 |
128710 | SLX4IP | P17T-E | Human | Esophagus | ESCC | 2.50e-04 | 2.64e-01 | 0.1278 |
128710 | SLX4IP | P20T-E | Human | Esophagus | ESCC | 1.53e-13 | 3.03e-01 | 0.1124 |
128710 | SLX4IP | P21T-E | Human | Esophagus | ESCC | 7.82e-16 | 2.23e-01 | 0.1617 |
128710 | SLX4IP | P22T-E | Human | Esophagus | ESCC | 2.95e-11 | 1.27e-01 | 0.1236 |
128710 | SLX4IP | P23T-E | Human | Esophagus | ESCC | 6.07e-17 | 3.89e-01 | 0.108 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLX4IP | SNV | Missense_Mutation | c.224N>T | p.Pro75Leu | p.P75L | Q5VYV7 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLX4IP | SNV | Missense_Mutation | novel | c.755N>A | p.Ser252Asn | p.S252N | Q5VYV7 | protein_coding | tolerated(0.14) | benign(0.039) | TCGA-B5-A11P-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLX4IP | SNV | Missense_Mutation | rs780563280 | c.178N>T | p.Arg60Cys | p.R60C | Q5VYV7 | protein_coding | deleterious(0.02) | benign(0.046) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SLX4IP | SNV | Missense_Mutation | rs773779960 | c.49N>A | p.Val17Met | p.V17M | Q5VYV7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
SLX4IP | SNV | Missense_Mutation | c.161N>G | p.Gln54Arg | p.Q54R | Q5VYV7 | protein_coding | deleterious(0.02) | benign(0.015) | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
SLX4IP | SNV | Missense_Mutation | rs766445670 | c.167A>G | p.Tyr56Cys | p.Y56C | Q5VYV7 | protein_coding | deleterious(0) | possibly_damaging(0.892) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
SLX4IP | SNV | Missense_Mutation | novel | c.319C>T | p.Leu107Phe | p.L107F | Q5VYV7 | protein_coding | deleterious(0.01) | possibly_damaging(0.799) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
SLX4IP | SNV | Missense_Mutation | rs138545867 | c.548C>T | p.Ser183Leu | p.S183L | Q5VYV7 | protein_coding | deleterious(0.03) | benign(0.021) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
SLX4IP | SNV | Missense_Mutation | rs752161612 | c.905C>T | p.Ala302Val | p.A302V | Q5VYV7 | protein_coding | tolerated(0.28) | benign(0.007) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SLX4IP | insertion | In_Frame_Ins | novel | c.946_947insCCTTTC | p.Asp316delinsAlaPheHis | p.D316delinsAFH | Q5VYV7 | protein_coding | TCGA-A5-A0GW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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