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Gene: SLTM |
Gene summary for SLTM |
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Gene information | Species | Human | Gene symbol | SLTM | Gene ID | 79811 |
Gene name | SAFB like transcription modulator | |
Gene Alias | Met | |
Cytomap | 15q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NWH9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79811 | SLTM | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.75e-21 | -6.90e-01 | 0.0155 |
79811 | SLTM | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.79e-06 | -5.38e-01 | -0.1808 |
79811 | SLTM | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.45e-04 | -5.52e-01 | -0.1207 |
79811 | SLTM | HTA11_83_2000001011 | Human | Colorectum | SER | 1.66e-03 | -4.78e-01 | -0.1526 |
79811 | SLTM | HTA11_696_2000001011 | Human | Colorectum | AD | 3.48e-11 | -5.22e-01 | -0.1464 |
79811 | SLTM | HTA11_866_2000001011 | Human | Colorectum | AD | 7.86e-14 | -5.17e-01 | -0.1001 |
79811 | SLTM | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.55e-02 | -3.94e-01 | -0.059 |
79811 | SLTM | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.97e-02 | -6.40e-01 | -0.2061 |
79811 | SLTM | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.96e-02 | -5.35e-01 | -0.0179 |
79811 | SLTM | HTA11_866_3004761011 | Human | Colorectum | AD | 2.68e-09 | -4.73e-01 | 0.096 |
79811 | SLTM | HTA11_8622_2000001021 | Human | Colorectum | SER | 7.07e-03 | -6.48e-01 | 0.0528 |
79811 | SLTM | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.68e-07 | -5.85e-01 | 0.0338 |
79811 | SLTM | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.57e-08 | -4.46e-01 | 0.0674 |
79811 | SLTM | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.62e-03 | -5.45e-01 | 0.0588 |
79811 | SLTM | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.49e-06 | -4.67e-01 | 0.3859 |
79811 | SLTM | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.27e-04 | -5.19e-01 | 0.2585 |
79811 | SLTM | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.03e-19 | -6.01e-01 | 0.3005 |
79811 | SLTM | A015-C-203 | Human | Colorectum | FAP | 3.06e-22 | -1.93e-01 | -0.1294 |
79811 | SLTM | A015-C-204 | Human | Colorectum | FAP | 9.61e-03 | 4.04e-02 | -0.0228 |
79811 | SLTM | A002-C-201 | Human | Colorectum | FAP | 2.32e-09 | -7.90e-02 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903311 | Colorectum | AD | regulation of mRNA metabolic process | 117/3918 | 288/18723 | 1.69e-14 | 4.23e-12 | 117 |
GO:0050684 | Colorectum | AD | regulation of mRNA processing | 61/3918 | 137/18723 | 4.23e-10 | 3.58e-08 | 61 |
GO:19033111 | Colorectum | SER | regulation of mRNA metabolic process | 78/2897 | 288/18723 | 2.61e-07 | 1.43e-05 | 78 |
GO:00506841 | Colorectum | SER | regulation of mRNA processing | 42/2897 | 137/18723 | 5.57e-06 | 2.01e-04 | 42 |
GO:19033112 | Colorectum | MSS | regulation of mRNA metabolic process | 115/3467 | 288/18723 | 1.23e-17 | 6.41e-15 | 115 |
GO:00506842 | Colorectum | MSS | regulation of mRNA processing | 57/3467 | 137/18723 | 2.88e-10 | 2.68e-08 | 57 |
GO:19033114 | Colorectum | FAP | regulation of mRNA metabolic process | 97/2622 | 288/18723 | 1.35e-17 | 4.13e-14 | 97 |
GO:00506844 | Colorectum | FAP | regulation of mRNA processing | 51/2622 | 137/18723 | 9.70e-12 | 4.96e-09 | 51 |
GO:19033115 | Colorectum | CRC | regulation of mRNA metabolic process | 80/2078 | 288/18723 | 3.21e-15 | 6.40e-12 | 80 |
GO:00506845 | Colorectum | CRC | regulation of mRNA processing | 41/2078 | 137/18723 | 1.57e-09 | 5.23e-07 | 41 |
GO:190331120 | Esophagus | HGIN | regulation of mRNA metabolic process | 91/2587 | 288/18723 | 5.06e-15 | 9.78e-13 | 91 |
GO:005068419 | Esophagus | HGIN | regulation of mRNA processing | 55/2587 | 137/18723 | 2.17e-14 | 3.94e-12 | 55 |
GO:1903311110 | Esophagus | ESCC | regulation of mRNA metabolic process | 210/8552 | 288/18723 | 3.25e-21 | 5.56e-19 | 210 |
GO:0050684110 | Esophagus | ESCC | regulation of mRNA processing | 109/8552 | 137/18723 | 3.51e-16 | 2.59e-14 | 109 |
GO:19033116 | Liver | NAFLD | regulation of mRNA metabolic process | 66/1882 | 288/18723 | 1.06e-10 | 2.96e-08 | 66 |
GO:00506846 | Liver | NAFLD | regulation of mRNA processing | 33/1882 | 137/18723 | 1.47e-06 | 6.73e-05 | 33 |
GO:190331111 | Liver | Cirrhotic | regulation of mRNA metabolic process | 140/4634 | 288/18723 | 1.07e-18 | 1.91e-16 | 140 |
GO:005068411 | Liver | Cirrhotic | regulation of mRNA processing | 81/4634 | 137/18723 | 1.05e-17 | 1.60e-15 | 81 |
GO:190331121 | Liver | HCC | regulation of mRNA metabolic process | 205/7958 | 288/18723 | 3.38e-23 | 6.90e-21 | 205 |
GO:005068421 | Liver | HCC | regulation of mRNA processing | 106/7958 | 137/18723 | 7.64e-17 | 7.12e-15 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLTM | SNV | Missense_Mutation | rs765954420 | c.3001N>A | p.Ala1001Thr | p.A1001T | Q9NWH9 | protein_coding | tolerated(0.05) | possibly_damaging(0.731) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLTM | SNV | Missense_Mutation | c.3098G>A | p.Arg1033Gln | p.R1033Q | Q9NWH9 | protein_coding | tolerated_low_confidence(0.32) | benign(0.097) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLTM | SNV | Missense_Mutation | novel | c.2086N>T | p.Arg696Cys | p.R696C | Q9NWH9 | protein_coding | deleterious(0.05) | possibly_damaging(0.599) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SLTM | SNV | Missense_Mutation | c.2068C>T | p.Arg690Cys | p.R690C | Q9NWH9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SLTM | SNV | Missense_Mutation | c.1496T>C | p.Val499Ala | p.V499A | Q9NWH9 | protein_coding | tolerated(0.52) | benign(0.011) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SLTM | SNV | Missense_Mutation | c.2389N>A | p.Val797Ile | p.V797I | Q9NWH9 | protein_coding | tolerated(0.13) | probably_damaging(0.942) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SLTM | SNV | Missense_Mutation | c.1474N>G | p.Ser492Gly | p.S492G | Q9NWH9 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SLTM | SNV | Missense_Mutation | novel | c.1940N>A | p.Arg647His | p.R647H | Q9NWH9 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLTM | SNV | Missense_Mutation | c.897N>T | p.Met299Ile | p.M299I | Q9NWH9 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLTM | insertion | Frame_Shift_Ins | novel | c.258_259insA | p.His87ThrfsTer2 | p.H87Tfs*2 | Q9NWH9 | protein_coding | TCGA-AD-6888-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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