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Gene: SLCO4C1 |
Gene summary for SLCO4C1 |
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Gene information | Species | Human | Gene symbol | SLCO4C1 | Gene ID | 353189 |
Gene name | solute carrier organic anion transporter family member 4C1 | |
Gene Alias | OATP-H | |
Cytomap | 5q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q6ZQN7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
353189 | SLCO4C1 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 5.62e-03 | 3.92e-01 | -0.1408 |
353189 | SLCO4C1 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 2.30e-02 | 2.70e-01 | -0.138 |
353189 | SLCO4C1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 5.77e-24 | 1.08e+00 | -0.2116 |
353189 | SLCO4C1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.59e-06 | 8.46e-01 | -0.1941 |
353189 | SLCO4C1 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 8.01e-07 | 1.01e+00 | -0.2107 |
353189 | SLCO4C1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.60e-21 | 1.09e+00 | -0.2119 |
353189 | SLCO4C1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.56e-02 | -1.90e-02 | -0.0132 |
353189 | SLCO4C1 | RNA-P8T2-P8T2-3 | Human | Lung | AIS | 1.80e-02 | 6.05e-01 | -0.1284 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLCO4C1 | SNV | Missense_Mutation | c.1140G>T | p.Lys380Asn | p.K380N | Q6ZQN7 | protein_coding | deleterious(0) | possibly_damaging(0.673) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLCO4C1 | SNV | Missense_Mutation | c.830N>A | p.Gly277Asp | p.G277D | Q6ZQN7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLCO4C1 | SNV | Missense_Mutation | c.265N>A | p.Gly89Ser | p.G89S | Q6ZQN7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLCO4C1 | SNV | Missense_Mutation | rs749246488 | c.1001N>A | p.Cys334Tyr | p.C334Y | Q6ZQN7 | protein_coding | tolerated(0.45) | benign(0.134) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLCO4C1 | SNV | Missense_Mutation | c.1919N>T | p.Ser640Ile | p.S640I | Q6ZQN7 | protein_coding | tolerated(0.38) | benign(0.315) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
SLCO4C1 | SNV | Missense_Mutation | novel | c.1660N>C | p.Ile554Leu | p.I554L | Q6ZQN7 | protein_coding | tolerated(0.67) | benign(0.003) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SLCO4C1 | SNV | Missense_Mutation | novel | c.1025N>T | p.Thr342Ile | p.T342I | Q6ZQN7 | protein_coding | deleterious(0) | possibly_damaging(0.463) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SLCO4C1 | SNV | Missense_Mutation | rs151106218 | c.1919N>A | p.Ser640Asn | p.S640N | Q6ZQN7 | protein_coding | tolerated(0.39) | benign(0.022) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLCO4C1 | SNV | Missense_Mutation | rs529284686 | c.1523N>T | p.Ser508Leu | p.S508L | Q6ZQN7 | protein_coding | tolerated(1) | benign(0.005) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
SLCO4C1 | SNV | Missense_Mutation | novel | c.2092G>A | p.Asp698Asn | p.D698N | Q6ZQN7 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
353189 | SLCO4C1 | TRANSPORTER, DRUGGABLE GENOME | 178101436 | |||
353189 | SLCO4C1 | TRANSPORTER, DRUGGABLE GENOME | Digoxin | DIGOXIN |
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