![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SLC6A15 |
Gene summary for SLC6A15 |
![]() |
Gene information | Species | Human | Gene symbol | SLC6A15 | Gene ID | 55117 |
Gene name | solute carrier family 6 member 15 | |
Gene Alias | NTT73 | |
Cytomap | 12q21.31 | |
Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | Q8IXG2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55117 | SLC6A15 | P2T-E | Human | Esophagus | ESCC | 1.33e-21 | 4.51e-01 | 0.1177 |
55117 | SLC6A15 | P5T-E | Human | Esophagus | ESCC | 2.86e-05 | 3.19e-02 | 0.1327 |
55117 | SLC6A15 | P10T-E | Human | Esophagus | ESCC | 1.75e-04 | 4.77e-02 | 0.116 |
55117 | SLC6A15 | P12T-E | Human | Esophagus | ESCC | 5.12e-04 | 1.99e-02 | 0.1122 |
55117 | SLC6A15 | P16T-E | Human | Esophagus | ESCC | 3.26e-54 | 9.89e-01 | 0.1153 |
55117 | SLC6A15 | P20T-E | Human | Esophagus | ESCC | 5.28e-10 | 7.63e-02 | 0.1124 |
55117 | SLC6A15 | P26T-E | Human | Esophagus | ESCC | 4.58e-12 | 2.37e-01 | 0.1276 |
55117 | SLC6A15 | P27T-E | Human | Esophagus | ESCC | 2.34e-02 | 3.94e-02 | 0.1055 |
55117 | SLC6A15 | P32T-E | Human | Esophagus | ESCC | 3.81e-12 | 2.40e-01 | 0.1666 |
55117 | SLC6A15 | P37T-E | Human | Esophagus | ESCC | 1.37e-10 | 3.02e-01 | 0.1371 |
55117 | SLC6A15 | P54T-E | Human | Esophagus | ESCC | 1.94e-13 | 2.93e-01 | 0.0975 |
55117 | SLC6A15 | P56T-E | Human | Esophagus | ESCC | 4.74e-06 | 8.16e-01 | 0.1613 |
55117 | SLC6A15 | P62T-E | Human | Esophagus | ESCC | 2.99e-03 | 1.49e-01 | 0.1302 |
55117 | SLC6A15 | P65T-E | Human | Esophagus | ESCC | 4.47e-03 | -3.21e-02 | 0.0978 |
55117 | SLC6A15 | P74T-E | Human | Esophagus | ESCC | 1.10e-03 | 1.18e-01 | 0.1479 |
55117 | SLC6A15 | P76T-E | Human | Esophagus | ESCC | 2.59e-03 | 1.21e-01 | 0.1207 |
55117 | SLC6A15 | P83T-E | Human | Esophagus | ESCC | 1.03e-09 | 3.57e-01 | 0.1738 |
55117 | SLC6A15 | P89T-E | Human | Esophagus | ESCC | 2.69e-06 | 8.37e-01 | 0.1752 |
55117 | SLC6A15 | P91T-E | Human | Esophagus | ESCC | 1.72e-05 | 9.24e-01 | 0.1828 |
55117 | SLC6A15 | P107T-E | Human | Esophagus | ESCC | 1.38e-19 | 4.92e-01 | 0.171 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC6A15 | SNV | Missense_Mutation | c.1900C>A | p.Pro634Thr | p.P634T | Q9H2J7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLC6A15 | SNV | Missense_Mutation | rs376347410 | c.1801G>A | p.Ala601Thr | p.A601T | Q9H2J7 | protein_coding | deleterious(0.02) | probably_damaging(0.975) | TCGA-AF-3913-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | xeloda | PD |
SLC6A15 | SNV | Missense_Mutation | novel | c.941N>G | p.Phe314Cys | p.F314C | Q9H2J7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC6A15 | SNV | Missense_Mutation | rs758867504 | c.1660N>G | p.Met554Val | p.M554V | Q9H2J7 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-AG-A00C-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
SLC6A15 | SNV | Missense_Mutation | c.2149N>G | p.Leu717Val | p.L717V | Q9H2J7 | protein_coding | tolerated_low_confidence(0.05) | benign(0.082) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLC6A15 | SNV | Missense_Mutation | novel | c.921N>A | p.Phe307Leu | p.F307L | Q9H2J7 | protein_coding | deleterious(0.01) | probably_damaging(0.967) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC6A15 | SNV | Missense_Mutation | novel | c.521N>C | p.Gln174Pro | p.Q174P | Q9H2J7 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC6A15 | deletion | Frame_Shift_Del | c.347delT | p.Phe116SerfsTer21 | p.F116Sfs*21 | Q9H2J7 | protein_coding | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |||
SLC6A15 | insertion | Frame_Shift_Ins | novel | c.1553_1554insAGCAAATATAC | p.Asn518LysfsTer21 | p.N518Kfs*21 | Q9H2J7 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC6A15 | insertion | In_Frame_Ins | novel | c.743_744insCTGTTTTTATTT | p.Gln248delinsHisCysPheTyrLeu | p.Q248delinsHCFYL | Q9H2J7 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55117 | SLC6A15 | DRUGGABLE GENOME, TRANSPORTER | inhibitor | 178103791 | LORATADINE | |
55117 | SLC6A15 | DRUGGABLE GENOME, TRANSPORTER | LORATADINE | LORATADINE | 25318072 |
Page: 1 |