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Gene: SLC43A2 |
Gene summary for SLC43A2 |
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Gene information | Species | Human | Gene symbol | SLC43A2 | Gene ID | 124935 |
Gene name | solute carrier family 43 member 2 | |
Gene Alias | LAT4 | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | Q8N370 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
124935 | SLC43A2 | P2T-E | Human | Esophagus | ESCC | 7.68e-09 | 2.78e-01 | 0.1177 |
124935 | SLC43A2 | P4T-E | Human | Esophagus | ESCC | 5.15e-04 | 1.73e-01 | 0.1323 |
124935 | SLC43A2 | P8T-E | Human | Esophagus | ESCC | 7.89e-11 | 1.32e-01 | 0.0889 |
124935 | SLC43A2 | P9T-E | Human | Esophagus | ESCC | 1.34e-02 | 6.55e-02 | 0.1131 |
124935 | SLC43A2 | P12T-E | Human | Esophagus | ESCC | 9.86e-07 | 1.41e-01 | 0.1122 |
124935 | SLC43A2 | P15T-E | Human | Esophagus | ESCC | 3.39e-03 | 1.99e-01 | 0.1149 |
124935 | SLC43A2 | P16T-E | Human | Esophagus | ESCC | 7.85e-31 | 6.29e-01 | 0.1153 |
124935 | SLC43A2 | P21T-E | Human | Esophagus | ESCC | 4.41e-19 | 3.56e-01 | 0.1617 |
124935 | SLC43A2 | P22T-E | Human | Esophagus | ESCC | 5.99e-06 | 2.06e-02 | 0.1236 |
124935 | SLC43A2 | P24T-E | Human | Esophagus | ESCC | 5.22e-09 | 2.06e-01 | 0.1287 |
124935 | SLC43A2 | P27T-E | Human | Esophagus | ESCC | 6.57e-14 | 1.32e-01 | 0.1055 |
124935 | SLC43A2 | P28T-E | Human | Esophagus | ESCC | 1.27e-08 | 9.73e-02 | 0.1149 |
124935 | SLC43A2 | P31T-E | Human | Esophagus | ESCC | 2.07e-07 | 1.62e-01 | 0.1251 |
124935 | SLC43A2 | P32T-E | Human | Esophagus | ESCC | 5.03e-11 | 2.54e-01 | 0.1666 |
124935 | SLC43A2 | P37T-E | Human | Esophagus | ESCC | 1.53e-11 | 1.95e-01 | 0.1371 |
124935 | SLC43A2 | P39T-E | Human | Esophagus | ESCC | 3.29e-02 | 2.70e-02 | 0.0894 |
124935 | SLC43A2 | P40T-E | Human | Esophagus | ESCC | 3.03e-02 | 9.91e-02 | 0.109 |
124935 | SLC43A2 | P42T-E | Human | Esophagus | ESCC | 1.45e-08 | 4.01e-01 | 0.1175 |
124935 | SLC43A2 | P47T-E | Human | Esophagus | ESCC | 3.91e-05 | 9.39e-02 | 0.1067 |
124935 | SLC43A2 | P48T-E | Human | Esophagus | ESCC | 8.43e-06 | 8.43e-02 | 0.0959 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510514 | Liver | Cirrhotic | negative regulation of transport | 141/4634 | 470/18723 | 5.06e-03 | 2.62e-02 | 141 |
GO:00510517 | Oral cavity | EOLP | negative regulation of transport | 80/2218 | 470/18723 | 5.11e-04 | 4.44e-03 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC43A2 | SNV | Missense_Mutation | novel | c.1555C>A | p.Leu519Met | p.L519M | Q8N370 | protein_coding | deleterious(0) | possibly_damaging(0.712) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
SLC43A2 | SNV | Missense_Mutation | novel | c.790N>G | p.Lys264Glu | p.K264E | Q8N370 | protein_coding | tolerated(1) | benign(0.138) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC43A2 | SNV | Missense_Mutation | novel | c.1174A>G | p.Arg392Gly | p.R392G | Q8N370 | protein_coding | deleterious(0) | benign(0.09) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
SLC43A2 | SNV | Missense_Mutation | c.166N>A | p.Val56Ile | p.V56I | Q8N370 | protein_coding | tolerated(0.63) | benign(0) | TCGA-BG-A0MQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC43A2 | SNV | Missense_Mutation | novel | c.1490C>T | p.Ala497Val | p.A497V | Q8N370 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC43A2 | SNV | Missense_Mutation | novel | c.252N>T | p.Gln84His | p.Q84H | Q8N370 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
SLC43A2 | SNV | Missense_Mutation | novel | c.857N>C | p.Val286Ala | p.V286A | Q8N370 | protein_coding | tolerated(0.79) | benign(0) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
SLC43A2 | SNV | Missense_Mutation | novel | c.1169N>G | p.Asp390Gly | p.D390G | Q8N370 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC43A2 | SNV | Missense_Mutation | c.1451N>T | p.Gln484Leu | p.Q484L | Q8N370 | protein_coding | tolerated(0.07) | benign(0.02) | TCGA-K7-A5RG-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC43A2 | SNV | Missense_Mutation | novel | c.892N>T | p.Thr298Ser | p.T298S | Q8N370 | protein_coding | tolerated(0.59) | benign(0.061) | TCGA-38-4631-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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