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Gene: SLC38A11 |
Gene summary for SLC38A11 |
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Gene information | Species | Human | Gene symbol | SLC38A11 | Gene ID | 151258 |
Gene name | solute carrier family 38 member 11 | |
Gene Alias | AVT2 | |
Cytomap | 2q24.3 | |
Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | Q08AI6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
151258 | SLC38A11 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.96e-35 | 7.12e-01 | 0.3005 |
151258 | SLC38A11 | CRC-1-8810 | Human | Colorectum | CRC | 1.40e-59 | 1.18e+00 | 0.6257 |
151258 | SLC38A11 | HCC1_Meng | Human | Liver | HCC | 1.68e-03 | -1.05e-01 | 0.0246 |
151258 | SLC38A11 | HCC2 | Human | Liver | HCC | 9.53e-11 | 1.23e-01 | 0.5341 |
151258 | SLC38A11 | S014 | Human | Liver | HCC | 6.29e-04 | 5.45e-01 | 0.2254 |
151258 | SLC38A11 | S016 | Human | Liver | HCC | 5.14e-12 | 6.80e-01 | 0.2243 |
151258 | SLC38A11 | HTA12-23-1 | Human | Pancreas | PDAC | 8.00e-12 | 8.81e-01 | 0.3405 |
151258 | SLC38A11 | HTA12-25-1 | Human | Pancreas | PDAC | 3.52e-06 | 5.06e-01 | 0.313 |
151258 | SLC38A11 | HTA12-26-1 | Human | Pancreas | PDAC | 4.88e-07 | 4.28e-01 | 0.3728 |
151258 | SLC38A11 | HTA12-29-1 | Human | Pancreas | PDAC | 6.38e-18 | 5.05e-01 | 0.3722 |
151258 | SLC38A11 | HTA12-32-1 | Human | Pancreas | PDAC | 1.46e-03 | 8.99e-01 | 0.3624 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068141 | Colorectum | CRC | sodium ion transport | 49/2078 | 245/18723 | 3.01e-05 | 7.86e-04 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC38A11 | SNV | Missense_Mutation | c.109G>T | p.Asp37Tyr | p.D37Y | Q08AI6 | protein_coding | tolerated(1) | benign(0.296) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC38A11 | SNV | Missense_Mutation | novel | c.1049N>T | p.Ala350Val | p.A350V | Q08AI6 | protein_coding | tolerated(1) | benign(0.009) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC38A11 | SNV | Missense_Mutation | novel | c.180N>G | p.Phe60Leu | p.F60L | Q08AI6 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC38A11 | SNV | Missense_Mutation | novel | c.491N>T | p.Ala164Val | p.A164V | Q08AI6 | protein_coding | tolerated(0.94) | benign(0.088) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
SLC38A11 | SNV | Missense_Mutation | novel | c.626T>G | p.Phe209Cys | p.F209C | Q08AI6 | protein_coding | tolerated(0.08) | benign(0.022) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
SLC38A11 | SNV | Missense_Mutation | c.40N>C | p.Phe14Leu | p.F14L | Q08AI6 | protein_coding | tolerated(0.53) | benign(0.001) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
SLC38A11 | SNV | Missense_Mutation | c.1188N>T | p.Gln396His | p.Q396H | Q08AI6 | protein_coding | deleterious_low_confidence(0) | benign(0.275) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC38A11 | SNV | Missense_Mutation | c.297N>A | p.Phe99Leu | p.F99L | Q08AI6 | protein_coding | tolerated(0.07) | benign(0.012) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC38A11 | SNV | Missense_Mutation | novel | c.409G>A | p.Gly137Arg | p.G137R | Q08AI6 | protein_coding | tolerated(0.35) | possibly_damaging(0.611) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
SLC38A11 | SNV | Missense_Mutation | novel | c.209N>G | p.Tyr70Cys | p.Y70C | Q08AI6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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