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Gene: SLC35G2 |
Gene summary for SLC35G2 |
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Gene information | Species | Human | Gene symbol | SLC35G2 | Gene ID | 80723 |
Gene name | solute carrier family 35 member G2 | |
Gene Alias | TMEM22 | |
Cytomap | 3q22.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8TBE7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80723 | SLC35G2 | CCI_1 | Human | Cervix | CC | 8.33e-06 | 3.69e-01 | 0.528 |
80723 | SLC35G2 | CCI_2 | Human | Cervix | CC | 9.58e-09 | 4.91e-01 | 0.5249 |
80723 | SLC35G2 | CCI_3 | Human | Cervix | CC | 2.82e-16 | 7.97e-01 | 0.516 |
80723 | SLC35G2 | T3 | Human | Cervix | CC | 9.19e-06 | 1.20e-01 | 0.1389 |
80723 | SLC35G2 | LZE6T | Human | Esophagus | ESCC | 1.94e-04 | 2.73e-01 | 0.0845 |
80723 | SLC35G2 | P9T-E | Human | Esophagus | ESCC | 7.62e-07 | 2.07e-01 | 0.1131 |
80723 | SLC35G2 | P12T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.69e-01 | 0.1122 |
80723 | SLC35G2 | P15T-E | Human | Esophagus | ESCC | 6.25e-05 | 1.21e-01 | 0.1149 |
80723 | SLC35G2 | P16T-E | Human | Esophagus | ESCC | 1.12e-13 | 2.65e-01 | 0.1153 |
80723 | SLC35G2 | P20T-E | Human | Esophagus | ESCC | 5.93e-07 | 1.82e-01 | 0.1124 |
80723 | SLC35G2 | P23T-E | Human | Esophagus | ESCC | 1.12e-02 | 1.41e-01 | 0.108 |
80723 | SLC35G2 | P24T-E | Human | Esophagus | ESCC | 7.44e-08 | 1.87e-01 | 0.1287 |
80723 | SLC35G2 | P26T-E | Human | Esophagus | ESCC | 7.23e-06 | 7.46e-02 | 0.1276 |
80723 | SLC35G2 | P27T-E | Human | Esophagus | ESCC | 4.67e-05 | 1.18e-01 | 0.1055 |
80723 | SLC35G2 | P31T-E | Human | Esophagus | ESCC | 2.42e-03 | 1.22e-01 | 0.1251 |
80723 | SLC35G2 | P37T-E | Human | Esophagus | ESCC | 4.13e-08 | 1.96e-01 | 0.1371 |
80723 | SLC35G2 | P42T-E | Human | Esophagus | ESCC | 1.84e-04 | 1.18e-01 | 0.1175 |
80723 | SLC35G2 | P47T-E | Human | Esophagus | ESCC | 2.39e-04 | 1.20e-01 | 0.1067 |
80723 | SLC35G2 | P52T-E | Human | Esophagus | ESCC | 6.05e-06 | 8.84e-02 | 0.1555 |
80723 | SLC35G2 | P54T-E | Human | Esophagus | ESCC | 4.81e-02 | 7.27e-02 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC35G2 | SNV | Missense_Mutation | novel | c.434N>C | p.Val145Ala | p.V145A | Q8TBE7 | protein_coding | tolerated(0.16) | possibly_damaging(0.788) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC35G2 | SNV | Missense_Mutation | novel | c.658N>C | p.Tyr220His | p.Y220H | Q8TBE7 | protein_coding | tolerated(0.54) | possibly_damaging(0.503) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
SLC35G2 | SNV | Missense_Mutation | novel | c.991G>A | p.Ala331Thr | p.A331T | Q8TBE7 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC35G2 | SNV | Missense_Mutation | novel | c.707N>C | p.Val236Ala | p.V236A | Q8TBE7 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC35G2 | SNV | Missense_Mutation | rs570589760 | c.382C>T | p.Arg128Trp | p.R128W | Q8TBE7 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC35G2 | deletion | Frame_Shift_Del | rs758765963 | c.192delA | p.Arg66GlufsTer18 | p.R66Efs*18 | Q8TBE7 | protein_coding | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC35G2 | deletion | Frame_Shift_Del | rs758765963 | c.192delA | p.Arg66GlufsTer18 | p.R66Efs*18 | Q8TBE7 | protein_coding | TCGA-AX-A3FS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC35G2 | deletion | Frame_Shift_Del | rs758765963 | c.184delN | p.Arg66GlufsTer18 | p.R66Efs*18 | Q8TBE7 | protein_coding | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC35G2 | deletion | Frame_Shift_Del | rs758765963 | c.184delN | p.Arg66GlufsTer18 | p.R66Efs*18 | Q8TBE7 | protein_coding | TCGA-B5-A0K2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Hormone Therapy | megace | SD | ||
SLC35G2 | deletion | Frame_Shift_Del | c.184_185delNN | p.Lys64ArgfsTer22 | p.K64Rfs*22 | Q8TBE7 | protein_coding | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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