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Gene: SLC26A3 |
Gene summary for SLC26A3 |
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Gene information | Species | Human | Gene symbol | SLC26A3 | Gene ID | 1811 |
Gene name | solute carrier family 26 member 3 | |
Gene Alias | CLD | |
Cytomap | 7q22.3-q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P40879 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1811 | SLC26A3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.11e-31 | -8.94e-01 | 0.0155 |
1811 | SLC26A3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.00e-02 | 1.28e+00 | -0.1808 |
1811 | SLC26A3 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.33e-04 | 9.43e-01 | -0.1088 |
1811 | SLC26A3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.11e-06 | 1.60e+00 | -0.1954 |
1811 | SLC26A3 | HTA11_411_2000001011 | Human | Colorectum | SER | 8.36e-03 | 8.03e-01 | -0.2602 |
1811 | SLC26A3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.63e-10 | 1.20e+00 | -0.2196 |
1811 | SLC26A3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.81e-15 | 1.11e+00 | -0.1207 |
1811 | SLC26A3 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.41e-05 | 7.40e-01 | -0.1526 |
1811 | SLC26A3 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.90e-07 | 1.05e+00 | -0.1464 |
1811 | SLC26A3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.87e-03 | 1.05e+00 | -0.1706 |
1811 | SLC26A3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.87e-15 | 1.71e+00 | -0.2061 |
1811 | SLC26A3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.79e-05 | -7.41e-01 | -0.0179 |
1811 | SLC26A3 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.54e-26 | -8.57e-01 | 0.096 |
1811 | SLC26A3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 8.72e-05 | -9.32e-01 | 0.0446 |
1811 | SLC26A3 | HTA11_9408_2000001011 | Human | Colorectum | AD | 4.54e-04 | -9.80e-01 | 0.0451 |
1811 | SLC26A3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.96e-05 | -7.76e-01 | 0.0528 |
1811 | SLC26A3 | HTA11_10623_2000001011 | Human | Colorectum | AD | 5.25e-10 | -9.56e-01 | -0.0177 |
1811 | SLC26A3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.85e-23 | -9.99e-01 | 0.0338 |
1811 | SLC26A3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.98e-41 | -1.01e+00 | 0.0674 |
1811 | SLC26A3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 6.14e-03 | -6.37e-01 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030004 | Colorectum | AD | cellular monovalent inorganic cation homeostasis | 36/3918 | 103/18723 | 6.80e-04 | 6.95e-03 | 36 |
GO:0030641 | Colorectum | AD | regulation of cellular pH | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
GO:0051591 | Colorectum | AD | response to cAMP | 31/3918 | 93/18723 | 3.59e-03 | 2.58e-02 | 31 |
GO:0071320 | Colorectum | AD | cellular response to cAMP | 20/3918 | 53/18723 | 3.71e-03 | 2.62e-02 | 20 |
GO:0051453 | Colorectum | AD | regulation of intracellular pH | 26/3918 | 75/18723 | 4.04e-03 | 2.82e-02 | 26 |
GO:0006885 | Colorectum | AD | regulation of pH | 30/3918 | 91/18723 | 4.95e-03 | 3.32e-02 | 30 |
GO:0055067 | Colorectum | AD | monovalent inorganic cation homeostasis | 45/3918 | 151/18723 | 6.19e-03 | 3.88e-02 | 45 |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:00300041 | Colorectum | SER | cellular monovalent inorganic cation homeostasis | 31/2897 | 103/18723 | 1.31e-04 | 2.66e-03 | 31 |
GO:00306411 | Colorectum | SER | regulation of cellular pH | 24/2897 | 81/18723 | 9.20e-04 | 1.11e-02 | 24 |
GO:00550671 | Colorectum | SER | monovalent inorganic cation homeostasis | 37/2897 | 151/18723 | 2.48e-03 | 2.33e-02 | 37 |
GO:00514531 | Colorectum | SER | regulation of intracellular pH | 21/2897 | 75/18723 | 3.97e-03 | 3.26e-02 | 21 |
GO:00068851 | Colorectum | SER | regulation of pH | 24/2897 | 91/18723 | 5.03e-03 | 3.88e-02 | 24 |
GO:00713201 | Colorectum | SER | cellular response to cAMP | 16/2897 | 53/18723 | 5.09e-03 | 3.91e-02 | 16 |
GO:00300042 | Colorectum | MSS | cellular monovalent inorganic cation homeostasis | 31/3467 | 103/18723 | 2.94e-03 | 2.27e-02 | 31 |
GO:00306412 | Colorectum | MSS | regulation of cellular pH | 25/3467 | 81/18723 | 4.97e-03 | 3.46e-02 | 25 |
GO:00515911 | Colorectum | FAP | response to cAMP | 27/2622 | 93/18723 | 1.26e-04 | 2.03e-03 | 27 |
GO:00300043 | Colorectum | FAP | cellular monovalent inorganic cation homeostasis | 28/2622 | 103/18723 | 3.23e-04 | 4.15e-03 | 28 |
GO:00514532 | Colorectum | FAP | regulation of intracellular pH | 22/2622 | 75/18723 | 4.38e-04 | 5.21e-03 | 22 |
GO:0046683 | Colorectum | FAP | response to organophosphorus | 33/2622 | 131/18723 | 4.61e-04 | 5.39e-03 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04972 | Colorectum | AD | Pancreatic secretion | 36/2092 | 102/8465 | 1.06e-02 | 3.98e-02 | 2.54e-02 | 36 |
hsa049721 | Colorectum | AD | Pancreatic secretion | 36/2092 | 102/8465 | 1.06e-02 | 3.98e-02 | 2.54e-02 | 36 |
hsa049722 | Colorectum | SER | Pancreatic secretion | 30/1580 | 102/8465 | 5.41e-03 | 3.28e-02 | 2.38e-02 | 30 |
hsa049723 | Colorectum | SER | Pancreatic secretion | 30/1580 | 102/8465 | 5.41e-03 | 3.28e-02 | 2.38e-02 | 30 |
hsa049724 | Colorectum | MSS | Pancreatic secretion | 33/1875 | 102/8465 | 1.09e-02 | 3.75e-02 | 2.30e-02 | 33 |
hsa049725 | Colorectum | MSS | Pancreatic secretion | 33/1875 | 102/8465 | 1.09e-02 | 3.75e-02 | 2.30e-02 | 33 |
hsa049726 | Colorectum | FAP | Pancreatic secretion | 34/1404 | 102/8465 | 2.43e-05 | 2.78e-04 | 1.69e-04 | 34 |
hsa049727 | Colorectum | FAP | Pancreatic secretion | 34/1404 | 102/8465 | 2.43e-05 | 2.78e-04 | 1.69e-04 | 34 |
hsa049728 | Colorectum | CRC | Pancreatic secretion | 32/1091 | 102/8465 | 7.86e-07 | 4.37e-05 | 2.96e-05 | 32 |
hsa049729 | Colorectum | CRC | Pancreatic secretion | 32/1091 | 102/8465 | 7.86e-07 | 4.37e-05 | 2.96e-05 | 32 |
hsa04978 | Stomach | GC | Mineral absorption | 15/708 | 60/8465 | 8.88e-05 | 9.80e-04 | 6.90e-04 | 15 |
hsa049781 | Stomach | GC | Mineral absorption | 15/708 | 60/8465 | 8.88e-05 | 9.80e-04 | 6.90e-04 | 15 |
hsa049788 | Stomach | SIM | Mineral absorption | 11/465 | 60/8465 | 3.61e-04 | 3.41e-03 | 2.74e-03 | 11 |
hsa049789 | Stomach | SIM | Mineral absorption | 11/465 | 60/8465 | 3.61e-04 | 3.41e-03 | 2.74e-03 | 11 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC26A3 | SNV | Missense_Mutation | c.850N>A | p.Asp284Asn | p.D284N | P40879 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SLC26A3 | SNV | Missense_Mutation | novel | c.154N>G | p.Arg52Gly | p.R52G | P40879 | protein_coding | tolerated(0.5) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
SLC26A3 | SNV | Missense_Mutation | c.1112G>T | p.Gly371Val | p.G371V | P40879 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
SLC26A3 | SNV | Missense_Mutation | c.911N>T | p.Ser304Phe | p.S304F | P40879 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SLC26A3 | SNV | Missense_Mutation | c.1261N>A | p.Val421Met | p.V421M | P40879 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SLC26A3 | SNV | Missense_Mutation | rs756707598 | c.2087N>A | p.Arg696Gln | p.R696Q | P40879 | protein_coding | tolerated(0.23) | benign(0.015) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC26A3 | SNV | Missense_Mutation | novel | c.1547G>T | p.Arg516Ile | p.R516I | P40879 | protein_coding | deleterious(0.01) | possibly_damaging(0.573) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC26A3 | SNV | Missense_Mutation | novel | c.727A>G | p.Ile243Val | p.I243V | P40879 | protein_coding | tolerated(0.28) | possibly_damaging(0.644) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC26A3 | SNV | Missense_Mutation | c.155G>T | p.Arg52Ile | p.R52I | P40879 | protein_coding | tolerated(0.17) | benign(0.067) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLC26A3 | insertion | Frame_Shift_Ins | novel | c.294_295insAGTAACT | p.Asp99SerfsTer3 | p.D99Sfs*3 | P40879 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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