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Gene: SLC25A43 |
Gene summary for SLC25A43 |
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Gene information | Species | Human | Gene symbol | SLC25A43 | Gene ID | 203427 |
Gene name | solute carrier family 25 member 43 | |
Gene Alias | SLC25A43 | |
Cytomap | Xq24 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8WUT9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
203427 | SLC25A43 | CCI_2 | Human | Cervix | CC | 3.11e-09 | 9.21e-01 | 0.5249 |
203427 | SLC25A43 | CCI_3 | Human | Cervix | CC | 9.28e-05 | 5.84e-01 | 0.516 |
203427 | SLC25A43 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.27e-09 | 5.37e-01 | -0.1954 |
203427 | SLC25A43 | A015-C-203 | Human | Colorectum | FAP | 1.42e-15 | -3.63e-01 | -0.1294 |
203427 | SLC25A43 | A014-C-040 | Human | Colorectum | FAP | 1.60e-03 | -4.40e-01 | -0.1184 |
203427 | SLC25A43 | A002-C-201 | Human | Colorectum | FAP | 6.57e-08 | -3.24e-01 | 0.0324 |
203427 | SLC25A43 | A001-C-119 | Human | Colorectum | FAP | 2.99e-04 | -3.85e-01 | -0.1557 |
203427 | SLC25A43 | A001-C-108 | Human | Colorectum | FAP | 1.41e-10 | -2.66e-01 | -0.0272 |
203427 | SLC25A43 | A002-C-205 | Human | Colorectum | FAP | 2.76e-09 | -3.06e-01 | -0.1236 |
203427 | SLC25A43 | A015-C-006 | Human | Colorectum | FAP | 1.24e-04 | -2.85e-01 | -0.0994 |
203427 | SLC25A43 | A015-C-106 | Human | Colorectum | FAP | 8.23e-09 | -2.82e-01 | -0.0511 |
203427 | SLC25A43 | A002-C-114 | Human | Colorectum | FAP | 4.25e-06 | -2.65e-01 | -0.1561 |
203427 | SLC25A43 | A015-C-104 | Human | Colorectum | FAP | 2.81e-15 | -2.99e-01 | -0.1899 |
203427 | SLC25A43 | A001-C-014 | Human | Colorectum | FAP | 2.74e-07 | -2.29e-01 | 0.0135 |
203427 | SLC25A43 | A002-C-016 | Human | Colorectum | FAP | 6.31e-08 | -2.72e-01 | 0.0521 |
203427 | SLC25A43 | A015-C-002 | Human | Colorectum | FAP | 1.52e-05 | -3.59e-01 | -0.0763 |
203427 | SLC25A43 | A001-C-203 | Human | Colorectum | FAP | 2.25e-05 | -1.72e-01 | -0.0481 |
203427 | SLC25A43 | A002-C-116 | Human | Colorectum | FAP | 9.58e-15 | -2.88e-01 | -0.0452 |
203427 | SLC25A43 | A014-C-008 | Human | Colorectum | FAP | 2.01e-05 | -3.29e-01 | -0.191 |
203427 | SLC25A43 | A018-E-020 | Human | Colorectum | FAP | 6.52e-09 | -3.30e-01 | -0.2034 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC25A43 | SNV | Missense_Mutation | novel | c.597N>A | p.Phe199Leu | p.F199L | Q8WUT9 | protein_coding | tolerated(0.49) | benign(0.007) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC25A43 | SNV | Missense_Mutation | c.875G>T | p.Arg292Ile | p.R292I | Q8WUT9 | protein_coding | deleterious(0.01) | possibly_damaging(0.55) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SLC25A43 | SNV | Missense_Mutation | novel | c.839N>G | p.Phe280Cys | p.F280C | Q8WUT9 | protein_coding | deleterious(0.02) | probably_damaging(0.971) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC25A43 | SNV | Missense_Mutation | novel | c.455N>A | p.Ser152Tyr | p.S152Y | Q8WUT9 | protein_coding | tolerated(1) | benign(0.003) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLC25A43 | SNV | Missense_Mutation | novel | c.365T>C | p.Ile122Thr | p.I122T | Q8WUT9 | protein_coding | tolerated(0.08) | benign(0.122) | TCGA-DD-AAD1-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SLC25A43 | SNV | Missense_Mutation | c.581N>T | p.Gly194Val | p.G194V | Q8WUT9 | protein_coding | tolerated(0.27) | benign(0.046) | TCGA-05-4410-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLC25A43 | SNV | Missense_Mutation | novel | c.587N>T | p.Arg196Leu | p.R196L | Q8WUT9 | protein_coding | tolerated(0.24) | benign(0.055) | TCGA-56-8626-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC25A43 | SNV | Missense_Mutation | novel | c.1006N>T | p.Pro336Ser | p.P336S | Q8WUT9 | protein_coding | tolerated_low_confidence(0.88) | benign(0) | TCGA-CN-5373-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC25A43 | SNV | Missense_Mutation | novel | c.727G>C | p.Asp243His | p.D243H | Q8WUT9 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-CQ-6218-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SLC25A43 | SNV | Missense_Mutation | novel | c.984N>A | p.Phe328Leu | p.F328L | Q8WUT9 | protein_coding | tolerated_low_confidence(0.51) | benign(0) | TCGA-CV-7099-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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