![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SLC22A25 |
Gene summary for SLC22A25 |
![]() |
Gene information | Species | Human | Gene symbol | SLC22A25 | Gene ID | 387601 |
Gene name | solute carrier family 22 member 25 | |
Gene Alias | HIMTP | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6T423 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
387601 | SLC22A25 | NAFLD1 | Human | Liver | NAFLD | 1.77e-09 | 9.53e-01 | -0.04 |
387601 | SLC22A25 | S41 | Human | Liver | Cirrhotic | 1.49e-03 | 6.35e-01 | -0.0343 |
387601 | SLC22A25 | S43 | Human | Liver | Cirrhotic | 2.37e-07 | -2.53e-01 | -0.0187 |
387601 | SLC22A25 | HCC1_Meng | Human | Liver | HCC | 4.21e-08 | -2.43e-01 | 0.0246 |
387601 | SLC22A25 | HCC2_Meng | Human | Liver | HCC | 2.32e-08 | -2.68e-01 | 0.0107 |
387601 | SLC22A25 | cirrhotic1 | Human | Liver | Cirrhotic | 1.07e-08 | -2.67e-01 | 0.0202 |
387601 | SLC22A25 | cirrhotic2 | Human | Liver | Cirrhotic | 1.92e-06 | -2.66e-01 | 0.0201 |
387601 | SLC22A25 | cirrhotic3 | Human | Liver | Cirrhotic | 3.06e-04 | -2.68e-01 | 0.0215 |
387601 | SLC22A25 | HCC1 | Human | Liver | HCC | 1.06e-31 | 6.59e-01 | 0.5336 |
387601 | SLC22A25 | HCC5 | Human | Liver | HCC | 4.82e-03 | 5.79e-01 | 0.4932 |
387601 | SLC22A25 | Pt13.a | Human | Liver | HCC | 3.25e-06 | -2.63e-01 | 0.021 |
387601 | SLC22A25 | Pt13.b | Human | Liver | HCC | 2.63e-03 | -2.68e-01 | 0.0251 |
387601 | SLC22A25 | Pt14.d | Human | Liver | HCC | 2.96e-06 | -2.63e-01 | 0.0143 |
387601 | SLC22A25 | S014 | Human | Liver | HCC | 3.63e-02 | -2.68e-01 | 0.2254 |
387601 | SLC22A25 | S016 | Human | Liver | HCC | 2.17e-03 | -2.68e-01 | 0.2243 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC22A25 | SNV | Missense_Mutation | c.504N>A | p.Asp168Glu | p.D168E | Q6T423 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AP-A05A-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
SLC22A25 | SNV | Missense_Mutation | novel | c.1400N>T | p.Arg467Ile | p.R467I | Q6T423 | protein_coding | tolerated(0.12) | benign(0.034) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC22A25 | SNV | Missense_Mutation | rs750672182 | c.418N>A | p.Glu140Lys | p.E140K | Q6T423 | protein_coding | deleterious(0.04) | benign(0.052) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
SLC22A25 | SNV | Missense_Mutation | novel | c.1483C>T | p.Pro495Ser | p.P495S | Q6T423 | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SLC22A25 | SNV | Missense_Mutation | c.687C>A | p.Phe229Leu | p.F229L | Q6T423 | protein_coding | tolerated(0.35) | benign(0.029) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC22A25 | SNV | Missense_Mutation | novel | c.1395N>T | p.Arg465Ser | p.R465S | Q6T423 | protein_coding | deleterious(0.05) | probably_damaging(0.997) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
SLC22A25 | SNV | Missense_Mutation | novel | c.341N>G | p.Glu114Gly | p.E114G | Q6T423 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC22A25 | SNV | Missense_Mutation | c.1007N>A | p.Ser336Tyr | p.S336Y | Q6T423 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
SLC22A25 | SNV | Missense_Mutation | rs368828937 | c.269N>A | p.Arg90His | p.R90H | Q6T423 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
SLC22A25 | SNV | Missense_Mutation | rs201958778 | c.608N>A | p.Arg203His | p.R203H | Q6T423 | protein_coding | deleterious(0.03) | possibly_damaging(0.843) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |