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Gene: SLC1A4 |
Gene summary for SLC1A4 |
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Gene information | Species | Human | Gene symbol | SLC1A4 | Gene ID | 6509 |
Gene name | solute carrier family 1 member 4 | |
Gene Alias | ASCT1 | |
Cytomap | 2p14 | |
Gene Type | protein-coding | GO ID | GO:0000101 | UniProtAcc | P43007 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6509 | SLC1A4 | LZE4T | Human | Esophagus | ESCC | 3.80e-04 | 9.19e-02 | 0.0811 |
6509 | SLC1A4 | LZE7T | Human | Esophagus | ESCC | 6.10e-05 | 2.20e-01 | 0.0667 |
6509 | SLC1A4 | LZE22T | Human | Esophagus | ESCC | 1.52e-03 | 2.55e-01 | 0.068 |
6509 | SLC1A4 | LZE21T | Human | Esophagus | ESCC | 6.73e-09 | 3.89e-01 | 0.0655 |
6509 | SLC1A4 | P2T-E | Human | Esophagus | ESCC | 8.22e-33 | 8.56e-01 | 0.1177 |
6509 | SLC1A4 | P4T-E | Human | Esophagus | ESCC | 1.93e-20 | 6.43e-01 | 0.1323 |
6509 | SLC1A4 | P5T-E | Human | Esophagus | ESCC | 4.05e-20 | 5.25e-01 | 0.1327 |
6509 | SLC1A4 | P8T-E | Human | Esophagus | ESCC | 2.41e-06 | 1.05e-01 | 0.0889 |
6509 | SLC1A4 | P9T-E | Human | Esophagus | ESCC | 4.13e-15 | 2.58e-01 | 0.1131 |
6509 | SLC1A4 | P10T-E | Human | Esophagus | ESCC | 4.81e-15 | 3.71e-01 | 0.116 |
6509 | SLC1A4 | P11T-E | Human | Esophagus | ESCC | 2.19e-16 | 1.03e+00 | 0.1426 |
6509 | SLC1A4 | P12T-E | Human | Esophagus | ESCC | 2.37e-21 | 5.80e-01 | 0.1122 |
6509 | SLC1A4 | P15T-E | Human | Esophagus | ESCC | 3.61e-22 | 7.64e-01 | 0.1149 |
6509 | SLC1A4 | P17T-E | Human | Esophagus | ESCC | 2.43e-03 | 3.75e-01 | 0.1278 |
6509 | SLC1A4 | P20T-E | Human | Esophagus | ESCC | 4.15e-35 | 1.17e+00 | 0.1124 |
6509 | SLC1A4 | P21T-E | Human | Esophagus | ESCC | 5.12e-29 | 7.78e-01 | 0.1617 |
6509 | SLC1A4 | P22T-E | Human | Esophagus | ESCC | 1.73e-19 | 4.75e-01 | 0.1236 |
6509 | SLC1A4 | P23T-E | Human | Esophagus | ESCC | 2.24e-08 | 5.61e-01 | 0.108 |
6509 | SLC1A4 | P24T-E | Human | Esophagus | ESCC | 8.76e-15 | 4.24e-01 | 0.1287 |
6509 | SLC1A4 | P26T-E | Human | Esophagus | ESCC | 4.91e-15 | 4.21e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:015010411 | Liver | HCC | transport across blood-brain barrier | 50/7958 | 87/18723 | 3.42e-03 | 1.55e-02 | 50 |
GO:001023211 | Liver | HCC | vascular transport | 50/7958 | 88/18723 | 4.69e-03 | 2.02e-02 | 50 |
GO:0032329 | Oral cavity | OSCC | serine transport | 9/7305 | 11/18723 | 4.85e-03 | 1.92e-02 | 9 |
GO:00323291 | Oral cavity | LP | serine transport | 7/4623 | 11/18723 | 7.01e-03 | 3.96e-02 | 7 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC1A4 | SNV | Missense_Mutation | novel | c.1328N>G | p.His443Arg | p.H443R | P43007 | protein_coding | tolerated(0.16) | benign(0) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
SLC1A4 | SNV | Missense_Mutation | novel | c.226N>A | p.Ala76Thr | p.A76T | P43007 | protein_coding | tolerated(0.05) | possibly_damaging(0.515) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SLC1A4 | SNV | Missense_Mutation | novel | c.457C>A | p.Leu153Met | p.L153M | P43007 | protein_coding | tolerated(0.16) | benign(0.091) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC1A4 | SNV | Missense_Mutation | novel | c.631A>C | p.Lys211Gln | p.K211Q | P43007 | protein_coding | tolerated(0.21) | benign(0.057) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SLC1A4 | insertion | Frame_Shift_Ins | novel | c.600_601insTTTCAAACAAACAAACA | p.Asn201PhefsTer13 | p.N201Ffs*13 | P43007 | protein_coding | TCGA-B5-A11I-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | PD | ||
SLC1A4 | SNV | Missense_Mutation | c.487N>A | p.Val163Ile | p.V163I | P43007 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-39-5029-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | docetaxel | PD | |
SLC1A4 | SNV | Missense_Mutation | novel | c.718N>G | p.Leu240Val | p.L240V | P43007 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-43-8115-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
SLC1A4 | SNV | Missense_Mutation | c.922C>A | p.His308Asn | p.H308N | P43007 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-56-6545-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC1A4 | SNV | Missense_Mutation | novel | c.1497N>G | p.Asn499Lys | p.N499K | P43007 | protein_coding | tolerated(0.92) | benign(0.05) | TCGA-56-A49D-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
SLC1A4 | SNV | Missense_Mutation | c.1449N>C | p.Lys483Asn | p.K483N | P43007 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-63-A5MH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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