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Gene: SLC10A7 |
Gene summary for SLC10A7 |
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Gene information | Species | Human | Gene symbol | SLC10A7 | Gene ID | 84068 |
Gene name | solute carrier family 10 member 7 | |
Gene Alias | C4orf13 | |
Cytomap | 4q31.22 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q0GE19 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84068 | SLC10A7 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.21e-07 | -4.07e-01 | 0.0155 |
84068 | SLC10A7 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.86e-06 | -4.18e-01 | 0.096 |
84068 | SLC10A7 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.08e-02 | -3.92e-01 | 0.0338 |
84068 | SLC10A7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.44e-07 | -3.67e-01 | 0.0674 |
84068 | SLC10A7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.98e-04 | -3.23e-01 | 0.294 |
84068 | SLC10A7 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.97e-02 | -4.86e-01 | 0.2585 |
84068 | SLC10A7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.13e-16 | -4.95e-01 | 0.3005 |
84068 | SLC10A7 | A015-C-203 | Human | Colorectum | FAP | 3.38e-21 | -4.24e-01 | -0.1294 |
84068 | SLC10A7 | A015-C-204 | Human | Colorectum | FAP | 5.51e-04 | -3.23e-01 | -0.0228 |
84068 | SLC10A7 | A002-C-201 | Human | Colorectum | FAP | 2.89e-08 | -3.28e-01 | 0.0324 |
84068 | SLC10A7 | A002-C-203 | Human | Colorectum | FAP | 1.68e-02 | -1.11e-01 | 0.2786 |
84068 | SLC10A7 | A001-C-119 | Human | Colorectum | FAP | 1.06e-08 | -5.03e-01 | -0.1557 |
84068 | SLC10A7 | A001-C-108 | Human | Colorectum | FAP | 6.82e-13 | -3.19e-01 | -0.0272 |
84068 | SLC10A7 | A002-C-205 | Human | Colorectum | FAP | 3.64e-13 | -3.69e-01 | -0.1236 |
84068 | SLC10A7 | A001-C-104 | Human | Colorectum | FAP | 7.77e-05 | -3.29e-01 | 0.0184 |
84068 | SLC10A7 | A015-C-005 | Human | Colorectum | FAP | 1.07e-02 | -2.43e-01 | -0.0336 |
84068 | SLC10A7 | A015-C-006 | Human | Colorectum | FAP | 3.00e-11 | -4.84e-01 | -0.0994 |
84068 | SLC10A7 | A015-C-106 | Human | Colorectum | FAP | 2.65e-08 | -3.16e-01 | -0.0511 |
84068 | SLC10A7 | A002-C-114 | Human | Colorectum | FAP | 1.78e-09 | -3.88e-01 | -0.1561 |
84068 | SLC10A7 | A015-C-104 | Human | Colorectum | FAP | 5.90e-24 | -4.24e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:00481932 | Colorectum | MSS | Golgi vesicle transport | 101/3467 | 296/18723 | 9.09e-11 | 9.77e-09 | 101 |
GO:00067902 | Colorectum | MSS | sulfur compound metabolic process | 85/3467 | 339/18723 | 1.52e-03 | 1.39e-02 | 85 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:00481934 | Colorectum | FAP | Golgi vesicle transport | 77/2622 | 296/18723 | 2.86e-08 | 2.62e-06 | 77 |
GO:00068691 | Colorectum | FAP | lipid transport | 81/2622 | 398/18723 | 2.84e-04 | 3.76e-03 | 81 |
GO:0006814 | Colorectum | FAP | sodium ion transport | 54/2622 | 245/18723 | 3.98e-04 | 4.85e-03 | 54 |
GO:00108762 | Colorectum | FAP | lipid localization | 85/2622 | 448/18723 | 1.92e-03 | 1.63e-02 | 85 |
GO:00481935 | Colorectum | CRC | Golgi vesicle transport | 59/2078 | 296/18723 | 5.47e-06 | 2.17e-04 | 59 |
GO:00068141 | Colorectum | CRC | sodium ion transport | 49/2078 | 245/18723 | 3.01e-05 | 7.86e-04 | 49 |
GO:0060348 | Colorectum | CRC | bone development | 37/2078 | 205/18723 | 1.96e-03 | 1.96e-02 | 37 |
GO:00068692 | Colorectum | CRC | lipid transport | 63/2078 | 398/18723 | 2.36e-03 | 2.26e-02 | 63 |
GO:00108763 | Colorectum | CRC | lipid localization | 68/2078 | 448/18723 | 4.60e-03 | 3.58e-02 | 68 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC10A7 | SNV | Missense_Mutation | c.602N>A | p.Pro201His | p.P201H | Q0GE19 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SLC10A7 | SNV | Missense_Mutation | rs759868895 | c.304N>A | p.Glu102Lys | p.E102K | Q0GE19 | protein_coding | tolerated(0.66) | benign(0.265) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC10A7 | SNV | Missense_Mutation | novel | c.902N>A | p.Ser301Tyr | p.S301Y | Q0GE19 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC10A7 | SNV | Missense_Mutation | novel | c.430N>G | p.Phe144Val | p.F144V | Q0GE19 | protein_coding | deleterious(0.01) | probably_damaging(0.91) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC10A7 | SNV | Missense_Mutation | novel | c.1015N>T | p.Pro339Ser | p.P339S | Q0GE19 | protein_coding | tolerated_low_confidence(0.18) | benign(0) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SLC10A7 | insertion | Frame_Shift_Ins | novel | c.912_913insACACAGGGCACTTGTCATTGGATAC | p.Leu305ThrfsTer46 | p.L305Tfs*46 | Q0GE19 | protein_coding | TCGA-B5-A11Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC10A7 | SNV | Missense_Mutation | c.986N>A | p.Arg329Lys | p.R329K | Q0GE19 | protein_coding | tolerated(0.2) | benign(0.007) | TCGA-HP-A5MZ-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC10A7 | SNV | Missense_Mutation | c.335N>T | p.Gly112Val | p.G112V | Q0GE19 | protein_coding | tolerated(0.09) | benign(0.186) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SLC10A7 | SNV | Missense_Mutation | c.993N>T | p.Lys331Asn | p.K331N | Q0GE19 | protein_coding | deleterious(0.05) | benign(0.043) | TCGA-55-5899-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
SLC10A7 | SNV | Missense_Mutation | c.142N>T | p.Ala48Ser | p.A48S | Q0GE19 | protein_coding | tolerated(1) | benign(0) | TCGA-78-7536-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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