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Gene: SIX5 |
Gene summary for SIX5 |
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Gene information | Species | Human | Gene symbol | SIX5 | Gene ID | 147912 |
Gene name | SIX homeobox 5 | |
Gene Alias | BOR2 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8N196 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
147912 | SIX5 | LZE24T | Human | Esophagus | ESCC | 3.48e-02 | 1.16e-01 | 0.0596 |
147912 | SIX5 | P1T-E | Human | Esophagus | ESCC | 4.01e-05 | 2.58e-01 | 0.0875 |
147912 | SIX5 | P2T-E | Human | Esophagus | ESCC | 5.54e-13 | 1.97e-01 | 0.1177 |
147912 | SIX5 | P4T-E | Human | Esophagus | ESCC | 9.77e-05 | 7.52e-02 | 0.1323 |
147912 | SIX5 | P5T-E | Human | Esophagus | ESCC | 1.31e-04 | 1.11e-01 | 0.1327 |
147912 | SIX5 | P8T-E | Human | Esophagus | ESCC | 5.11e-14 | 2.60e-01 | 0.0889 |
147912 | SIX5 | P9T-E | Human | Esophagus | ESCC | 1.01e-03 | 1.30e-01 | 0.1131 |
147912 | SIX5 | P10T-E | Human | Esophagus | ESCC | 4.59e-08 | 2.09e-01 | 0.116 |
147912 | SIX5 | P11T-E | Human | Esophagus | ESCC | 2.36e-05 | 2.18e-01 | 0.1426 |
147912 | SIX5 | P12T-E | Human | Esophagus | ESCC | 7.65e-09 | 1.41e-01 | 0.1122 |
147912 | SIX5 | P15T-E | Human | Esophagus | ESCC | 1.01e-13 | 1.44e-01 | 0.1149 |
147912 | SIX5 | P16T-E | Human | Esophagus | ESCC | 5.31e-09 | 1.76e-01 | 0.1153 |
147912 | SIX5 | P17T-E | Human | Esophagus | ESCC | 3.59e-03 | 1.87e-01 | 0.1278 |
147912 | SIX5 | P19T-E | Human | Esophagus | ESCC | 4.43e-03 | 2.63e-01 | 0.1662 |
147912 | SIX5 | P20T-E | Human | Esophagus | ESCC | 1.45e-06 | 1.52e-01 | 0.1124 |
147912 | SIX5 | P21T-E | Human | Esophagus | ESCC | 2.56e-09 | 1.78e-01 | 0.1617 |
147912 | SIX5 | P22T-E | Human | Esophagus | ESCC | 1.96e-08 | 1.46e-01 | 0.1236 |
147912 | SIX5 | P23T-E | Human | Esophagus | ESCC | 3.34e-07 | 1.88e-01 | 0.108 |
147912 | SIX5 | P24T-E | Human | Esophagus | ESCC | 1.02e-03 | 1.00e-01 | 0.1287 |
147912 | SIX5 | P27T-E | Human | Esophagus | ESCC | 7.63e-06 | 1.04e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00330025 | Esophagus | ESCC | muscle cell proliferation | 134/8552 | 248/18723 | 4.80e-03 | 1.86e-02 | 134 |
GO:00330024 | Oral cavity | OSCC | muscle cell proliferation | 115/7305 | 248/18723 | 1.05e-02 | 3.58e-02 | 115 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIX5 | SNV | Missense_Mutation | c.1693N>A | p.Ala565Thr | p.A565T | Q8N196 | protein_coding | tolerated(0.09) | possibly_damaging(0.468) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SIX5 | SNV | Missense_Mutation | c.2056N>A | p.Gly686Arg | p.G686R | Q8N196 | protein_coding | deleterious(0.02) | benign(0.182) | TCGA-D1-A0ZS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SIX5 | SNV | Missense_Mutation | novel | c.1898N>A | p.Ser633Asn | p.S633N | Q8N196 | protein_coding | tolerated(0.2) | benign(0.015) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SIX5 | SNV | Missense_Mutation | novel | c.1130N>G | p.Ala377Gly | p.A377G | Q8N196 | protein_coding | tolerated(0.07) | benign(0.011) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
SIX5 | SNV | Missense_Mutation | rs781343581 | c.1687N>T | p.Leu563Phe | p.L563F | Q8N196 | protein_coding | tolerated(0.17) | possibly_damaging(0.844) | TCGA-EY-A1H0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
SIX5 | SNV | Missense_Mutation | novel | c.1843N>C | p.Gly615Arg | p.G615R | Q8N196 | protein_coding | deleterious(0.01) | benign(0.218) | TCGA-KJ-A3U4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | PD |
SIX5 | SNV | Missense_Mutation | novel | c.1130C>G | p.Ala377Gly | p.A377G | Q8N196 | protein_coding | tolerated(0.07) | benign(0.011) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SIX5 | deletion | Frame_Shift_Del | novel | c.1952delN | p.Pro651HisfsTer5 | p.P651Hfs*5 | Q8N196 | protein_coding | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SIX5 | SNV | Missense_Mutation | novel | c.737G>T | p.Ser246Ile | p.S246I | Q8N196 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DD-AACJ-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SIX5 | SNV | Missense_Mutation | novel | c.81N>C | p.Glu27Asp | p.E27D | Q8N196 | protein_coding | tolerated_low_confidence(0.12) | possibly_damaging(0.818) | TCGA-DD-AACZ-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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