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Gene: SIRT7 |
Gene summary for SIRT7 |
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Gene information | Species | Human | Gene symbol | SIRT7 | Gene ID | 51547 |
Gene name | sirtuin 7 | |
Gene Alias | SIR2L7 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9NRC8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51547 | SIRT7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.30e-08 | 5.58e-01 | -0.1808 |
51547 | SIRT7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.56e-03 | 2.61e-01 | -0.0811 |
51547 | SIRT7 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.59e-07 | 3.09e-01 | -0.1954 |
51547 | SIRT7 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.38e-03 | 7.64e-01 | -0.2602 |
51547 | SIRT7 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.85e-03 | 5.89e-01 | -0.2196 |
51547 | SIRT7 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.34e-05 | 4.13e-01 | -0.1526 |
51547 | SIRT7 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.69e-04 | 3.39e-01 | -0.1464 |
51547 | SIRT7 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.74e-04 | 2.47e-01 | -0.1001 |
51547 | SIRT7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.43e-07 | 3.17e-01 | -0.059 |
51547 | SIRT7 | A002-C-205 | Human | Colorectum | FAP | 1.15e-02 | -1.40e-01 | -0.1236 |
51547 | SIRT7 | A002-C-116 | Human | Colorectum | FAP | 7.37e-03 | -1.05e-01 | -0.0452 |
51547 | SIRT7 | LZE2T | Human | Esophagus | ESCC | 2.02e-02 | 3.72e-01 | 0.082 |
51547 | SIRT7 | LZE7T | Human | Esophagus | ESCC | 2.59e-09 | 3.56e-01 | 0.0667 |
51547 | SIRT7 | LZE20T | Human | Esophagus | ESCC | 1.04e-05 | 2.18e-01 | 0.0662 |
51547 | SIRT7 | LZE22T | Human | Esophagus | ESCC | 2.78e-14 | 5.42e-01 | 0.068 |
51547 | SIRT7 | LZE24T | Human | Esophagus | ESCC | 4.83e-34 | 7.81e-01 | 0.0596 |
51547 | SIRT7 | LZE21T | Human | Esophagus | ESCC | 5.65e-10 | 6.14e-01 | 0.0655 |
51547 | SIRT7 | P1T-E | Human | Esophagus | ESCC | 7.67e-22 | 6.81e-01 | 0.0875 |
51547 | SIRT7 | P2T-E | Human | Esophagus | ESCC | 1.36e-15 | 2.79e-01 | 0.1177 |
51547 | SIRT7 | P4T-E | Human | Esophagus | ESCC | 6.07e-18 | 3.66e-01 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:1903320 | Colorectum | AD | regulation of protein modification by small protein conjugation or removal | 86/3918 | 242/18723 | 9.43e-08 | 4.65e-06 | 86 |
GO:0006913 | Colorectum | AD | nucleocytoplasmic transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0051169 | Colorectum | AD | nuclear transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0010821 | Colorectum | AD | regulation of mitochondrion organization | 57/3918 | 144/18723 | 2.43e-07 | 9.92e-06 | 57 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0033157 | Colorectum | AD | regulation of intracellular protein transport | 80/3918 | 229/18723 | 5.81e-07 | 2.09e-05 | 80 |
GO:0031396 | Colorectum | AD | regulation of protein ubiquitination | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:0019318 | Colorectum | AD | hexose metabolic process | 77/3918 | 237/18723 | 1.96e-05 | 4.01e-04 | 77 |
GO:0046822 | Colorectum | AD | regulation of nucleocytoplasmic transport | 41/3918 | 106/18723 | 2.17e-05 | 4.33e-04 | 41 |
GO:0031397 | Colorectum | AD | negative regulation of protein ubiquitination | 34/3918 | 83/18723 | 2.66e-05 | 5.04e-04 | 34 |
GO:2001020 | Colorectum | AD | regulation of response to DNA damage stimulus | 71/3918 | 219/18723 | 4.38e-05 | 7.65e-04 | 71 |
GO:1903321 | Colorectum | AD | negative regulation of protein modification by small protein conjugation or removal | 37/3918 | 95/18723 | 4.49e-05 | 7.83e-04 | 37 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0051168 | Colorectum | AD | nuclear export | 53/3918 | 154/18723 | 6.89e-05 | 1.11e-03 | 53 |
GO:0005996 | Colorectum | AD | monosaccharide metabolic process | 80/3918 | 257/18723 | 7.31e-05 | 1.17e-03 | 80 |
GO:0006006 | Colorectum | AD | glucose metabolic process | 62/3918 | 196/18723 | 2.76e-04 | 3.39e-03 | 62 |
GO:0001649 | Colorectum | AD | osteoblast differentiation | 70/3918 | 229/18723 | 3.59e-04 | 4.18e-03 | 70 |
GO:0006611 | Colorectum | AD | protein export from nucleus | 23/3918 | 57/18723 | 6.62e-04 | 6.80e-03 | 23 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIRT7 | SNV | Missense_Mutation | c.790N>T | p.Ile264Phe | p.I264F | Q9NRC8 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | |
SIRT7 | SNV | Missense_Mutation | novel | c.31N>T | p.Arg11Cys | p.R11C | Q9NRC8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-55-7574-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
SIRT7 | SNV | Missense_Mutation | c.595G>T | p.Val199Phe | p.V199F | Q9NRC8 | protein_coding | deleterious(0.03) | benign(0.01) | TCGA-69-7973-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
SIRT7 | SNV | Missense_Mutation | c.876G>C | p.Lys292Asn | p.K292N | Q9NRC8 | protein_coding | deleterious(0.04) | benign(0.188) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
SIRT7 | SNV | Missense_Mutation | novel | c.450N>A | p.Met150Ile | p.M150I | Q9NRC8 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-34-8454-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
SIRT7 | SNV | Missense_Mutation | c.1022N>G | p.Phe341Cys | p.F341C | Q9NRC8 | protein_coding | deleterious(0) | possibly_damaging(0.847) | TCGA-37-4141-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIRT7 | SNV | Missense_Mutation | c.803N>T | p.Gly268Val | p.G268V | Q9NRC8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-66-2789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SIRT7 | deletion | Frame_Shift_Del | c.9delN | p.Gly5ValfsTer2 | p.G5Vfs*2 | Q9NRC8 | protein_coding | TCGA-75-6205-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD | |||
SIRT7 | SNV | Missense_Mutation | novel | c.49G>A | p.Val17Ile | p.V17I | Q9NRC8 | protein_coding | tolerated(0.2) | benign(0.025) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SIRT7 | SNV | Missense_Mutation | rs760278283 | c.341N>T | p.Ala114Val | p.A114V | Q9NRC8 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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