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Gene: SIGLEC6 |
Gene summary for SIGLEC6 |
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Gene information | Species | Human | Gene symbol | SIGLEC6 | Gene ID | 946 |
Gene name | sialic acid binding Ig like lectin 6 | |
Gene Alias | CD327 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | O43699 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
946 | SIGLEC6 | HCC1 | Human | Liver | HCC | 1.89e-02 | 2.43e-01 | 0.5336 |
946 | SIGLEC6 | HCC2 | Human | Liver | HCC | 2.08e-08 | 1.76e+00 | 0.5341 |
946 | SIGLEC6 | HCC5 | Human | Liver | HCC | 1.75e-08 | 5.99e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIGLEC6 | SNV | Missense_Mutation | c.247N>A | p.Glu83Lys | p.E83K | O43699 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-DY-A1DG-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SIGLEC6 | SNV | Missense_Mutation | rs772851483 | c.364N>T | p.Arg122Trp | p.R122W | O43699 | protein_coding | deleterious(0.04) | possibly_damaging(0.565) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
SIGLEC6 | SNV | Missense_Mutation | c.1187G>T | p.Arg396Met | p.R396M | O43699 | protein_coding | tolerated(0.11) | benign(0.43) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SIGLEC6 | SNV | Missense_Mutation | rs772851483 | c.364C>T | p.Arg122Trp | p.R122W | O43699 | protein_coding | deleterious(0.04) | possibly_damaging(0.565) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SIGLEC6 | SNV | Missense_Mutation | novel | c.34A>G | p.Met12Val | p.M12V | O43699 | protein_coding | deleterious_low_confidence(0) | benign(0.017) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SIGLEC6 | SNV | Missense_Mutation | novel | c.1197G>T | p.Gln399His | p.Q399H | O43699 | protein_coding | tolerated(0.15) | possibly_damaging(0.531) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SIGLEC6 | SNV | Missense_Mutation | c.1031N>A | p.Ala344Asp | p.A344D | O43699 | protein_coding | deleterious(0.04) | benign(0.039) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SIGLEC6 | SNV | Missense_Mutation | rs183822218 | c.958N>T | p.Arg320Cys | p.R320C | O43699 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
SIGLEC6 | SNV | Missense_Mutation | novel | c.808N>G | p.Leu270Val | p.L270V | O43699 | protein_coding | deleterious(0.04) | probably_damaging(0.914) | TCGA-AJ-A3BD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
SIGLEC6 | SNV | Missense_Mutation | novel | c.1113N>T | p.Lys371Asn | p.K371N | O43699 | protein_coding | deleterious(0.02) | benign(0.021) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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