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Gene: SFR1 |
Gene summary for SFR1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SFR1 | Gene ID | 119392 |
Gene name | SWI5 dependent homologous recombination repair protein 1 | |
Gene Alias | C10orf78 | |
Cytomap | 10q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000724 | UniProtAcc | Q86XK3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
119392 | SFR1 | LZE4T | Human | Esophagus | ESCC | 2.37e-02 | 9.05e-02 | 0.0811 |
119392 | SFR1 | LZE24T | Human | Esophagus | ESCC | 8.40e-17 | 3.53e-01 | 0.0596 |
119392 | SFR1 | P2T-E | Human | Esophagus | ESCC | 5.47e-14 | 2.25e-01 | 0.1177 |
119392 | SFR1 | P4T-E | Human | Esophagus | ESCC | 3.85e-16 | 3.20e-01 | 0.1323 |
119392 | SFR1 | P5T-E | Human | Esophagus | ESCC | 5.12e-47 | 8.88e-01 | 0.1327 |
119392 | SFR1 | P8T-E | Human | Esophagus | ESCC | 2.16e-04 | 1.31e-01 | 0.0889 |
119392 | SFR1 | P9T-E | Human | Esophagus | ESCC | 8.38e-03 | 8.14e-02 | 0.1131 |
119392 | SFR1 | P11T-E | Human | Esophagus | ESCC | 2.06e-07 | 2.17e-01 | 0.1426 |
119392 | SFR1 | P12T-E | Human | Esophagus | ESCC | 1.13e-13 | 1.91e-01 | 0.1122 |
119392 | SFR1 | P15T-E | Human | Esophagus | ESCC | 5.37e-05 | 1.15e-01 | 0.1149 |
119392 | SFR1 | P16T-E | Human | Esophagus | ESCC | 1.55e-04 | 1.04e-01 | 0.1153 |
119392 | SFR1 | P17T-E | Human | Esophagus | ESCC | 4.79e-04 | 2.03e-01 | 0.1278 |
119392 | SFR1 | P19T-E | Human | Esophagus | ESCC | 2.95e-08 | 6.54e-01 | 0.1662 |
119392 | SFR1 | P20T-E | Human | Esophagus | ESCC | 2.18e-13 | 2.54e-01 | 0.1124 |
119392 | SFR1 | P21T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.85e-01 | 0.1617 |
119392 | SFR1 | P23T-E | Human | Esophagus | ESCC | 7.24e-11 | 2.36e-01 | 0.108 |
119392 | SFR1 | P24T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.40e-01 | 0.1287 |
119392 | SFR1 | P26T-E | Human | Esophagus | ESCC | 2.19e-14 | 2.59e-01 | 0.1276 |
119392 | SFR1 | P27T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.59e-01 | 0.1055 |
119392 | SFR1 | P28T-E | Human | Esophagus | ESCC | 1.34e-05 | 1.12e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:00007241 | Esophagus | ESCC | double-strand break repair via homologous recombination | 79/8552 | 138/18723 | 4.05e-03 | 1.62e-02 | 79 |
GO:00007251 | Esophagus | ESCC | recombinational repair | 80/8552 | 140/18723 | 4.10e-03 | 1.63e-02 | 80 |
GO:00436275 | Esophagus | ESCC | response to estrogen | 45/8552 | 75/18723 | 8.75e-03 | 3.08e-02 | 45 |
GO:00063023 | Oral cavity | OSCC | double-strand break repair | 132/7305 | 251/18723 | 7.93e-06 | 8.52e-05 | 132 |
GO:0006310 | Oral cavity | OSCC | DNA recombination | 147/7305 | 305/18723 | 6.33e-04 | 3.56e-03 | 147 |
GO:0000725 | Oral cavity | OSCC | recombinational repair | 70/7305 | 140/18723 | 5.22e-03 | 2.03e-02 | 70 |
GO:0000724 | Oral cavity | OSCC | double-strand break repair via homologous recombination | 69/7305 | 138/18723 | 5.52e-03 | 2.14e-02 | 69 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SFR1 | SNV | Missense_Mutation | c.104N>T | p.Ser35Leu | p.S35L | Q86XK3 | protein_coding | tolerated(0.1) | benign(0.131) | TCGA-CR-7379-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SFR1 | SNV | Missense_Mutation | c.492G>T | p.Gln164His | p.Q164H | Q86XK3 | protein_coding | deleterious(0.01) | benign(0.073) | TCGA-HC-7080-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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