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Gene: SETD7 |
Gene summary for SETD7 |
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Gene information | Species | Human | Gene symbol | SETD7 | Gene ID | 80854 |
Gene name | SET domain containing 7, histone lysine methyltransferase | |
Gene Alias | KMT7 | |
Cytomap | 4q31.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | D6RJA0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80854 | SETD7 | LZE4T | Human | Esophagus | ESCC | 9.81e-06 | 6.97e-02 | 0.0811 |
80854 | SETD7 | LZE7T | Human | Esophagus | ESCC | 7.37e-03 | 1.51e-01 | 0.0667 |
80854 | SETD7 | LZE22T | Human | Esophagus | ESCC | 1.23e-02 | 1.75e-01 | 0.068 |
80854 | SETD7 | LZE24T | Human | Esophagus | ESCC | 2.66e-10 | 1.78e-01 | 0.0596 |
80854 | SETD7 | P1T-E | Human | Esophagus | ESCC | 2.80e-02 | 8.95e-02 | 0.0875 |
80854 | SETD7 | P2T-E | Human | Esophagus | ESCC | 6.37e-09 | 1.26e-01 | 0.1177 |
80854 | SETD7 | P4T-E | Human | Esophagus | ESCC | 8.29e-10 | 2.19e-01 | 0.1323 |
80854 | SETD7 | P5T-E | Human | Esophagus | ESCC | 2.28e-11 | 1.66e-02 | 0.1327 |
80854 | SETD7 | P8T-E | Human | Esophagus | ESCC | 9.66e-13 | 1.16e-01 | 0.0889 |
80854 | SETD7 | P9T-E | Human | Esophagus | ESCC | 2.22e-07 | 1.76e-01 | 0.1131 |
80854 | SETD7 | P10T-E | Human | Esophagus | ESCC | 7.17e-07 | -8.03e-03 | 0.116 |
80854 | SETD7 | P11T-E | Human | Esophagus | ESCC | 1.29e-04 | 2.43e-01 | 0.1426 |
80854 | SETD7 | P12T-E | Human | Esophagus | ESCC | 1.78e-11 | 2.06e-01 | 0.1122 |
80854 | SETD7 | P15T-E | Human | Esophagus | ESCC | 8.35e-07 | 4.77e-02 | 0.1149 |
80854 | SETD7 | P16T-E | Human | Esophagus | ESCC | 4.49e-04 | 6.19e-02 | 0.1153 |
80854 | SETD7 | P17T-E | Human | Esophagus | ESCC | 6.32e-04 | 1.52e-01 | 0.1278 |
80854 | SETD7 | P20T-E | Human | Esophagus | ESCC | 8.92e-08 | 5.10e-02 | 0.1124 |
80854 | SETD7 | P21T-E | Human | Esophagus | ESCC | 5.06e-03 | -3.98e-02 | 0.1617 |
80854 | SETD7 | P22T-E | Human | Esophagus | ESCC | 7.32e-13 | 2.03e-01 | 0.1236 |
80854 | SETD7 | P23T-E | Human | Esophagus | ESCC | 1.26e-10 | 1.23e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:003105614 | Esophagus | ESCC | regulation of histone modification | 106/8552 | 152/18723 | 1.52e-09 | 3.55e-08 | 106 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:000647914 | Esophagus | ESCC | protein methylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:000821314 | Esophagus | ESCC | protein alkylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:00165718 | Esophagus | ESCC | histone methylation | 89/8552 | 141/18723 | 2.17e-05 | 1.87e-04 | 89 |
GO:003496814 | Esophagus | ESCC | histone lysine methylation | 72/8552 | 115/18723 | 1.85e-04 | 1.18e-03 | 72 |
GO:003106013 | Esophagus | ESCC | regulation of histone methylation | 46/8552 | 69/18723 | 3.46e-04 | 2.03e-03 | 46 |
GO:001802214 | Esophagus | ESCC | peptidyl-lysine methylation | 79/8552 | 131/18723 | 5.17e-04 | 2.86e-03 | 79 |
GO:00708281 | Esophagus | ESCC | heterochromatin organization | 31/8552 | 46/18723 | 2.42e-03 | 1.06e-02 | 31 |
GO:0097305111 | Esophagus | ESCC | response to alcohol | 138/8552 | 253/18723 | 2.70e-03 | 1.14e-02 | 138 |
GO:001657021 | Liver | HCC | histone modification | 283/7958 | 463/18723 | 2.68e-16 | 2.33e-14 | 283 |
GO:00182052 | Liver | HCC | peptidyl-lysine modification | 230/7958 | 376/18723 | 1.51e-13 | 8.32e-12 | 230 |
GO:003105621 | Liver | HCC | regulation of histone modification | 99/7958 | 152/18723 | 1.40e-08 | 3.40e-07 | 99 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:00064792 | Liver | HCC | protein methylation | 111/7958 | 181/18723 | 2.36e-07 | 4.18e-06 | 111 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa040689 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
hsa0031010 | Esophagus | ESCC | Lysine degradation | 41/4205 | 63/8465 | 9.63e-03 | 2.27e-02 | 1.16e-02 | 41 |
hsa0406814 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
hsa0031013 | Esophagus | ESCC | Lysine degradation | 41/4205 | 63/8465 | 9.63e-03 | 2.27e-02 | 1.16e-02 | 41 |
hsa0031041 | Liver | HCC | Lysine degradation | 47/4020 | 63/8465 | 1.02e-05 | 7.58e-05 | 4.22e-05 | 47 |
hsa040684 | Liver | HCC | FoxO signaling pathway | 85/4020 | 131/8465 | 3.99e-05 | 2.16e-04 | 1.20e-04 | 85 |
hsa0031051 | Liver | HCC | Lysine degradation | 47/4020 | 63/8465 | 1.02e-05 | 7.58e-05 | 4.22e-05 | 47 |
hsa040685 | Liver | HCC | FoxO signaling pathway | 85/4020 | 131/8465 | 3.99e-05 | 2.16e-04 | 1.20e-04 | 85 |
hsa040687 | Prostate | BPH | FoxO signaling pathway | 54/1718 | 131/8465 | 3.05e-08 | 3.59e-07 | 2.22e-07 | 54 |
hsa0406812 | Prostate | BPH | FoxO signaling pathway | 54/1718 | 131/8465 | 3.05e-08 | 3.59e-07 | 2.22e-07 | 54 |
hsa0406822 | Prostate | Tumor | FoxO signaling pathway | 54/1791 | 131/8465 | 1.32e-07 | 1.51e-06 | 9.36e-07 | 54 |
hsa0406832 | Prostate | Tumor | FoxO signaling pathway | 54/1791 | 131/8465 | 1.32e-07 | 1.51e-06 | 9.36e-07 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SETD7 | SNV | Missense_Mutation | c.934N>T | p.Arg312Cys | p.R312C | Q8WTS6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SETD7 | SNV | Missense_Mutation | rs754434053 | c.818C>T | p.Thr273Met | p.T273M | Q8WTS6 | protein_coding | tolerated(0.08) | probably_damaging(0.983) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SETD7 | SNV | Missense_Mutation | novel | c.536G>A | p.Arg179Lys | p.R179K | Q8WTS6 | protein_coding | tolerated(0.69) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SETD7 | SNV | Missense_Mutation | c.170G>T | p.Ser57Ile | p.S57I | Q8WTS6 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SETD7 | SNV | Missense_Mutation | novel | c.368N>G | p.Tyr123Cys | p.Y123C | Q8WTS6 | protein_coding | tolerated(0.12) | possibly_damaging(0.626) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
SETD7 | SNV | Missense_Mutation | novel | c.485G>T | p.Gly162Val | p.G162V | Q8WTS6 | protein_coding | deleterious(0) | possibly_damaging(0.563) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SETD7 | SNV | Missense_Mutation | rs770383668 | c.943N>T | p.Pro315Ser | p.P315S | Q8WTS6 | protein_coding | tolerated(0.73) | benign(0.001) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
SETD7 | SNV | Missense_Mutation | novel | c.476N>G | p.Phe159Cys | p.F159C | Q8WTS6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
SETD7 | SNV | Missense_Mutation | novel | c.244C>A | p.Leu82Ile | p.L82I | Q8WTS6 | protein_coding | tolerated(0.21) | possibly_damaging(0.57) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
SETD7 | SNV | Missense_Mutation | c.419N>A | p.Thr140Asn | p.T140N | Q8WTS6 | protein_coding | tolerated(0.1) | possibly_damaging(0.76) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
80854 | SETD7 | ENZYME, METHYL TRANSFERASE | inhibitor | 249565915 | ||
80854 | SETD7 | ENZYME, METHYL TRANSFERASE | SINEFUNGIN | SINEFUNGIN | 23981144 | |
80854 | SETD7 | ENZYME, METHYL TRANSFERASE | EOSIN | EOSIN | 18348515 |
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