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Gene: SEMA4F |
Gene summary for SEMA4F |
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Gene information | Species | Human | Gene symbol | SEMA4F | Gene ID | 10505 |
Gene name | ssemaphorin 4F | |
Gene Alias | M-SEMA | |
Cytomap | 2p13.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O95754 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10505 | SEMA4F | HCC1_Meng | Human | Liver | HCC | 1.96e-04 | -2.22e-03 | 0.0246 |
10505 | SEMA4F | HCC1 | Human | Liver | HCC | 3.89e-18 | 1.90e+00 | 0.5336 |
10505 | SEMA4F | HCC2 | Human | Liver | HCC | 2.72e-31 | 3.00e+00 | 0.5341 |
10505 | SEMA4F | HCC5 | Human | Liver | HCC | 1.28e-22 | 1.74e+00 | 0.4932 |
10505 | SEMA4F | S029 | Human | Liver | HCC | 4.64e-03 | 1.25e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:003253522 | Liver | HCC | regulation of cellular component size | 217/7958 | 383/18723 | 1.28e-08 | 3.14e-07 | 217 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
GO:006056011 | Liver | HCC | developmental growth involved in morphogenesis | 124/7958 | 234/18723 | 7.37e-04 | 4.47e-03 | 124 |
GO:001097511 | Liver | HCC | regulation of neuron projection development | 220/7958 | 445/18723 | 1.68e-03 | 8.78e-03 | 220 |
GO:00459263 | Liver | HCC | negative regulation of growth | 129/7958 | 249/18723 | 1.81e-03 | 9.37e-03 | 129 |
GO:004867511 | Liver | HCC | axon extension | 67/7958 | 120/18723 | 2.17e-03 | 1.09e-02 | 67 |
GO:199013811 | Liver | HCC | neuron projection extension | 92/7958 | 172/18723 | 2.31e-03 | 1.14e-02 | 92 |
GO:004858811 | Liver | HCC | developmental cell growth | 121/7958 | 234/18723 | 2.68e-03 | 1.28e-02 | 121 |
GO:00507674 | Liver | HCC | regulation of neurogenesis | 181/7958 | 364/18723 | 3.00e-03 | 1.40e-02 | 181 |
GO:00083614 | Liver | HCC | regulation of cell size | 95/7958 | 181/18723 | 4.15e-03 | 1.81e-02 | 95 |
GO:0030308 | Liver | HCC | negative regulation of cell growth | 98/7958 | 188/18723 | 4.74e-03 | 2.02e-02 | 98 |
GO:00305164 | Liver | HCC | regulation of axon extension | 52/7958 | 95/18723 | 1.07e-02 | 3.97e-02 | 52 |
GO:000166721 | Liver | HCC | ameboidal-type cell migration | 226/7958 | 475/18723 | 1.35e-02 | 4.81e-02 | 226 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEMA4F | SNV | Missense_Mutation | rs775752097 | c.2047N>T | p.Arg683Cys | p.R683C | O95754 | protein_coding | tolerated(0.07) | benign(0.165) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEMA4F | SNV | Missense_Mutation | rs373277680 | c.2174G>A | p.Arg725Gln | p.R725Q | O95754 | protein_coding | tolerated(0.09) | probably_damaging(0.968) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SEMA4F | SNV | Missense_Mutation | rs183645100 | c.1210N>A | p.Val404Ile | p.V404I | O95754 | protein_coding | deleterious(0) | possibly_damaging(0.88) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEMA4F | SNV | Missense_Mutation | novel | c.2063G>A | p.Arg688Gln | p.R688Q | O95754 | protein_coding | tolerated(0.19) | probably_damaging(0.968) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SEMA4F | SNV | Missense_Mutation | rs375899286 | c.640N>T | p.Arg214Trp | p.R214W | O95754 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
SEMA4F | SNV | Missense_Mutation | rs746352642 | c.172N>A | p.Ala58Thr | p.A58T | O95754 | protein_coding | tolerated(0.19) | benign(0) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEMA4F | SNV | Missense_Mutation | novel | c.485N>C | p.Arg162Thr | p.R162T | O95754 | protein_coding | tolerated(0.14) | benign(0.027) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SEMA4F | SNV | Missense_Mutation | novel | c.550N>A | p.Gly184Arg | p.G184R | O95754 | protein_coding | deleterious(0.03) | probably_damaging(0.979) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
SEMA4F | SNV | Missense_Mutation | rs747881367 | c.788N>A | p.Arg263His | p.R263H | O95754 | protein_coding | tolerated(0.24) | benign(0.005) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEMA4F | SNV | Missense_Mutation | c.202C>A | p.Leu68Ile | p.L68I | O95754 | protein_coding | deleterious(0.03) | probably_damaging(0.954) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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