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Gene: SEC13 |
Gene summary for SEC13 |
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Gene information | Species | Human | Gene symbol | SEC13 | Gene ID | 6396 |
Gene name | SEC13 homolog, nuclear pore and COPII coat complex component | |
Gene Alias | D3S1231E | |
Cytomap | 3p25.3 | |
Gene Type | protein-coding | GO ID | GO:0006403 | UniProtAcc | P55735 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6396 | SEC13 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.87e-03 | 3.31e-02 | 0.0155 |
6396 | SEC13 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.09e-12 | 6.69e-01 | -0.1808 |
6396 | SEC13 | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.28e-04 | 4.09e-01 | -0.0811 |
6396 | SEC13 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.67e-09 | 4.98e-01 | -0.1088 |
6396 | SEC13 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.36e-21 | 6.45e-01 | -0.1954 |
6396 | SEC13 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.62e-06 | 1.10e+00 | -0.2602 |
6396 | SEC13 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.63e-07 | 8.42e-01 | -0.2196 |
6396 | SEC13 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.90e-08 | 5.48e-01 | -0.1207 |
6396 | SEC13 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.47e-22 | 7.19e-01 | -0.1464 |
6396 | SEC13 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.02e-03 | 3.27e-01 | -0.1001 |
6396 | SEC13 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.74e-13 | 6.72e-01 | -0.059 |
6396 | SEC13 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.68e-02 | 5.67e-01 | -0.1706 |
6396 | SEC13 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.05e-04 | 3.40e-01 | 0.096 |
6396 | SEC13 | HTA11_6801_2000001011 | Human | Colorectum | SER | 7.16e-03 | 6.12e-01 | 0.0171 |
6396 | SEC13 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.41e-02 | 3.00e-01 | 0.0674 |
6396 | SEC13 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.72e-05 | 3.25e-01 | 0.0588 |
6396 | SEC13 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.80e-16 | 5.54e-01 | 0.294 |
6396 | SEC13 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.83e-06 | 4.72e-01 | 0.281 |
6396 | SEC13 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.06e-18 | 7.70e-01 | 0.3859 |
6396 | SEC13 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.30e-03 | 3.56e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0006900 | Colorectum | AD | vesicle budding from membrane | 32/3918 | 61/18723 | 5.38e-08 | 2.81e-06 | 32 |
GO:0006913 | Colorectum | AD | nucleocytoplasmic transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0051169 | Colorectum | AD | nuclear transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
GO:0034504 | Colorectum | AD | protein localization to nucleus | 94/3918 | 290/18723 | 2.83e-06 | 8.09e-05 | 94 |
GO:0051236 | Colorectum | AD | establishment of RNA localization | 58/3918 | 166/18723 | 1.95e-05 | 4.01e-04 | 58 |
GO:0015931 | Colorectum | AD | nucleobase-containing compound transport | 73/3918 | 222/18723 | 2.02e-05 | 4.10e-04 | 73 |
GO:0050657 | Colorectum | AD | nucleic acid transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
GO:0050658 | Colorectum | AD | RNA transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
GO:0017038 | Colorectum | AD | protein import | 67/3918 | 206/18723 | 6.34e-05 | 1.05e-03 | 67 |
GO:0051170 | Colorectum | AD | import into nucleus | 53/3918 | 159/18723 | 1.76e-04 | 2.38e-03 | 53 |
GO:0006606 | Colorectum | AD | protein import into nucleus | 51/3918 | 155/18723 | 3.29e-04 | 3.86e-03 | 51 |
GO:0006888 | Colorectum | AD | endoplasmic reticulum to Golgi vesicle-mediated transport | 44/3918 | 130/18723 | 4.13e-04 | 4.68e-03 | 44 |
GO:0051028 | Colorectum | AD | mRNA transport | 42/3918 | 130/18723 | 1.57e-03 | 1.32e-02 | 42 |
GO:00725941 | Colorectum | SER | establishment of protein localization to organelle | 111/2897 | 422/18723 | 4.98e-09 | 4.49e-07 | 111 |
GO:00481931 | Colorectum | SER | Golgi vesicle transport | 79/2897 | 296/18723 | 4.20e-07 | 2.15e-05 | 79 |
GO:00069131 | Colorectum | SER | nucleocytoplasmic transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa050142 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa050143 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa050144 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa04150 | Colorectum | MSS | mTOR signaling pathway | 47/1875 | 156/8465 | 1.19e-02 | 3.99e-02 | 2.44e-02 | 47 |
hsa050145 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041501 | Colorectum | MSS | mTOR signaling pathway | 47/1875 | 156/8465 | 1.19e-02 | 3.99e-02 | 2.44e-02 | 47 |
hsa050148 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa041418 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa050149 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa041419 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa0501430 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa0414139 | Esophagus | HGIN | Protein processing in endoplasmic reticulum | 67/1383 | 174/8465 | 1.06e-12 | 2.16e-11 | 1.72e-11 | 67 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEC13 | SNV | Missense_Mutation | c.396N>C | p.Trp132Cys | p.W132C | P55735 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SEC13 | SNV | Missense_Mutation | novel | c.763N>C | p.Glu255Gln | p.E255Q | P55735 | protein_coding | tolerated(0.3) | benign(0.139) | TCGA-55-6982-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | gemzar | PD |
SEC13 | SNV | Missense_Mutation | novel | c.11C>A | p.Pro4His | p.P4H | P55735 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-MP-A4TC-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | CR |
SEC13 | insertion | Frame_Shift_Ins | novel | c.42_43insTTATTTTTTTT | p.Cys16PhefsTer15 | p.C16Ffs*15 | P55735 | protein_coding | TCGA-62-A46V-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SEC13 | SNV | Missense_Mutation | novel | c.544N>T | p.Gly182Trp | p.G182W | P55735 | protein_coding | deleterious(0.01) | probably_damaging(0.965) | TCGA-CR-7379-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEC13 | SNV | Missense_Mutation | rs201150723 | c.266G>A | p.Arg89His | p.R89H | P55735 | protein_coding | tolerated(0.06) | benign(0.198) | TCGA-UF-A7JO-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SEC13 | SNV | Missense_Mutation | novel | c.774N>G | p.Ser258Arg | p.S258R | P55735 | protein_coding | tolerated(0.09) | probably_damaging(0.958) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SEC13 | SNV | Missense_Mutation | rs766208174 | c.365N>T | p.Ser122Leu | p.S122L | P55735 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
SEC13 | SNV | Missense_Mutation | rs757416423 | c.265N>T | p.Arg89Cys | p.R89C | P55735 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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