![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SCRN2 |
Gene summary for SCRN2 |
![]() |
Gene information | Species | Human | Gene symbol | SCRN2 | Gene ID | 90507 |
Gene name | secernin 2 | |
Gene Alias | Ses2 | |
Cytomap | 17q21.32 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q96FV2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90507 | SCRN2 | LZE3D | Human | Esophagus | HGIN | 2.57e-02 | 3.97e-01 | 0.0668 |
90507 | SCRN2 | LZE4T | Human | Esophagus | ESCC | 1.15e-04 | 8.36e-02 | 0.0811 |
90507 | SCRN2 | LZE7T | Human | Esophagus | ESCC | 1.80e-07 | 2.46e-01 | 0.0667 |
90507 | SCRN2 | LZE8T | Human | Esophagus | ESCC | 5.20e-09 | 1.76e-01 | 0.067 |
90507 | SCRN2 | LZE20T | Human | Esophagus | ESCC | 1.14e-02 | 4.18e-02 | 0.0662 |
90507 | SCRN2 | LZE22D1 | Human | Esophagus | HGIN | 1.13e-04 | 1.12e-01 | 0.0595 |
90507 | SCRN2 | LZE24T | Human | Esophagus | ESCC | 1.79e-23 | 5.55e-01 | 0.0596 |
90507 | SCRN2 | LZE22D3 | Human | Esophagus | HGIN | 5.07e-04 | 4.96e-01 | 0.0653 |
90507 | SCRN2 | LZE21T | Human | Esophagus | ESCC | 3.36e-05 | 1.41e-01 | 0.0655 |
90507 | SCRN2 | LZE6T | Human | Esophagus | ESCC | 3.29e-07 | 3.62e-01 | 0.0845 |
90507 | SCRN2 | P1T-E | Human | Esophagus | ESCC | 1.24e-10 | 6.22e-01 | 0.0875 |
90507 | SCRN2 | P2T-E | Human | Esophagus | ESCC | 5.31e-16 | 3.61e-01 | 0.1177 |
90507 | SCRN2 | P4T-E | Human | Esophagus | ESCC | 3.73e-39 | 7.36e-01 | 0.1323 |
90507 | SCRN2 | P5T-E | Human | Esophagus | ESCC | 2.56e-27 | 5.67e-01 | 0.1327 |
90507 | SCRN2 | P8T-E | Human | Esophagus | ESCC | 3.09e-24 | 4.43e-01 | 0.0889 |
90507 | SCRN2 | P9T-E | Human | Esophagus | ESCC | 4.83e-16 | 2.37e-01 | 0.1131 |
90507 | SCRN2 | P10T-E | Human | Esophagus | ESCC | 8.78e-17 | 1.93e-01 | 0.116 |
90507 | SCRN2 | P11T-E | Human | Esophagus | ESCC | 7.83e-10 | 4.50e-01 | 0.1426 |
90507 | SCRN2 | P12T-E | Human | Esophagus | ESCC | 1.42e-28 | 5.06e-01 | 0.1122 |
90507 | SCRN2 | P15T-E | Human | Esophagus | ESCC | 6.52e-19 | 3.12e-01 | 0.1149 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCRN2 | SNV | Missense_Mutation | c.497N>A | p.Arg166His | p.R166H | Q96FV2 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SCRN2 | SNV | Missense_Mutation | rs570410687 | c.659N>A | p.Gly220Glu | p.G220E | Q96FV2 | protein_coding | tolerated(0.05) | probably_damaging(1) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SCRN2 | deletion | Frame_Shift_Del | novel | c.776delN | p.Gly259AlafsTer6 | p.G259Afs*6 | Q96FV2 | protein_coding | TCGA-AP-A05N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SCRN2 | insertion | In_Frame_Ins | novel | c.915_916insCTT | p.Leu305dup | p.L305dup | Q96FV2 | protein_coding | TCGA-D1-A0ZP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | ||
SCRN2 | SNV | Missense_Mutation | c.805N>G | p.Leu269Val | p.L269V | Q96FV2 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-DD-A73G-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SCRN2 | SNV | Missense_Mutation | c.214G>T | p.Ala72Ser | p.A72S | Q96FV2 | protein_coding | deleterious(0.02) | benign(0.431) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
SCRN2 | SNV | Missense_Mutation | c.425A>T | p.Tyr142Phe | p.Y142F | Q96FV2 | protein_coding | deleterious(0.02) | benign(0.037) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SCRN2 | SNV | Missense_Mutation | novel | c.555G>T | p.Gln185His | p.Q185H | Q96FV2 | protein_coding | deleterious(0.04) | possibly_damaging(0.601) | TCGA-21-1076-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SCRN2 | SNV | Missense_Mutation | rs781445482 | c.262N>A | p.Ala88Thr | p.A88T | Q96FV2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SCRN2 | SNV | Missense_Mutation | novel | c.455N>T | p.Ala152Val | p.A152V | Q96FV2 | protein_coding | tolerated(0.12) | benign(0.03) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |