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Gene: SCMH1 |
Gene summary for SCMH1 |
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Gene information | Species | Human | Gene symbol | SCMH1 | Gene ID | 22955 |
Gene name | Scm polycomb group protein homolog 1 | |
Gene Alias | Scml3 | |
Cytomap | 1p34.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q96GD3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22955 | SCMH1 | CCI_3 | Human | Cervix | CC | 4.52e-11 | 6.29e-01 | 0.516 |
22955 | SCMH1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.68e-31 | -7.42e-01 | 0.0155 |
22955 | SCMH1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.87e-13 | -5.95e-01 | -0.1808 |
22955 | SCMH1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.54e-06 | -5.69e-01 | -0.1207 |
22955 | SCMH1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.67e-11 | -4.68e-01 | -0.1464 |
22955 | SCMH1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.81e-04 | -3.94e-01 | -0.1001 |
22955 | SCMH1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.40e-06 | -7.72e-01 | -0.2061 |
22955 | SCMH1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.25e-03 | -5.77e-01 | -0.00410000000000005 |
22955 | SCMH1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.47e-06 | -4.25e-01 | 0.096 |
22955 | SCMH1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.84e-04 | -8.10e-01 | 0.0451 |
22955 | SCMH1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.90e-07 | -4.29e-01 | 0.0338 |
22955 | SCMH1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.79e-07 | -3.89e-01 | 0.0674 |
22955 | SCMH1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.80e-04 | -2.33e-01 | 0.294 |
22955 | SCMH1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.27e-07 | -5.41e-01 | 0.2585 |
22955 | SCMH1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.34e-15 | -5.03e-01 | 0.3005 |
22955 | SCMH1 | F007 | Human | Colorectum | FAP | 2.55e-04 | -2.92e-01 | 0.1176 |
22955 | SCMH1 | A001-C-207 | Human | Colorectum | FAP | 1.35e-05 | -1.64e-01 | 0.1278 |
22955 | SCMH1 | A015-C-203 | Human | Colorectum | FAP | 9.56e-33 | -5.33e-01 | -0.1294 |
22955 | SCMH1 | A015-C-204 | Human | Colorectum | FAP | 3.72e-07 | -2.50e-01 | -0.0228 |
22955 | SCMH1 | A014-C-040 | Human | Colorectum | FAP | 3.85e-05 | -1.82e-01 | -0.1184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00063381 | Cervix | CC | chromatin remodeling | 45/2311 | 255/18723 | 8.33e-03 | 4.30e-02 | 45 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:00063253 | Colorectum | FAP | chromatin organization | 84/2622 | 409/18723 | 1.62e-04 | 2.47e-03 | 84 |
GO:0009952 | Colorectum | FAP | anterior/posterior pattern specification | 41/2622 | 201/18723 | 7.82e-03 | 4.63e-02 | 41 |
GO:00063254 | Colorectum | CRC | chromatin organization | 74/2078 | 409/18723 | 1.48e-05 | 4.61e-04 | 74 |
GO:00099521 | Colorectum | CRC | anterior/posterior pattern specification | 36/2078 | 201/18723 | 2.56e-03 | 2.40e-02 | 36 |
GO:00063258 | Endometrium | AEH | chromatin organization | 64/2100 | 409/18723 | 3.69e-03 | 2.52e-02 | 64 |
GO:000632513 | Endometrium | EEC | chromatin organization | 65/2168 | 409/18723 | 4.98e-03 | 3.14e-02 | 65 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00063255 | Liver | NAFLD | chromatin organization | 64/1882 | 409/18723 | 2.31e-04 | 3.89e-03 | 64 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:00063256 | Lung | IAC | chromatin organization | 69/2061 | 409/18723 | 2.01e-04 | 3.53e-03 | 69 |
GO:000632512 | Lung | AIS | chromatin organization | 62/1849 | 409/18723 | 4.24e-04 | 7.29e-03 | 62 |
GO:00063259 | Prostate | BPH | chromatin organization | 101/3107 | 409/18723 | 1.52e-05 | 1.94e-04 | 101 |
GO:00063382 | Prostate | BPH | chromatin remodeling | 62/3107 | 255/18723 | 9.47e-04 | 5.97e-03 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
SCMH1 | NK | Endometrium | EEC | LDB2,DIAPH3,LINC01572, etc. | 2.51e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCMH1 | SNV | Missense_Mutation | rs766997779 | c.307N>T | p.Arg103Trp | p.R103W | Q96GD3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCMH1 | SNV | Missense_Mutation | novel | c.854C>T | p.Pro285Leu | p.P285L | Q96GD3 | protein_coding | tolerated(0.09) | benign(0.322) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SCMH1 | SNV | Missense_Mutation | rs376970948 | c.1166N>A | p.Arg389His | p.R389H | Q96GD3 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCMH1 | SNV | Missense_Mutation | novel | c.272G>A | p.Arg91His | p.R91H | Q96GD3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SCMH1 | SNV | Missense_Mutation | c.1838N>T | p.Ala613Val | p.A613V | Q96GD3 | protein_coding | tolerated(0.06) | benign(0.19) | TCGA-D1-A17A-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SCMH1 | SNV | Missense_Mutation | novel | c.1333N>C | p.Tyr445His | p.Y445H | Q96GD3 | protein_coding | deleterious(0.01) | possibly_damaging(0.905) | TCGA-D1-A3DH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCMH1 | SNV | Missense_Mutation | novel | c.1357N>T | p.Leu453Phe | p.L453F | Q96GD3 | protein_coding | tolerated(0.19) | possibly_damaging(0.758) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SCMH1 | SNV | Missense_Mutation | novel | c.1069N>A | p.Pro357Thr | p.P357T | Q96GD3 | protein_coding | deleterious(0.04) | possibly_damaging(0.47) | TCGA-E6-A2P8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SCMH1 | SNV | Missense_Mutation | novel | c.1022N>A | p.Thr341Asn | p.T341N | Q96GD3 | protein_coding | tolerated(0.16) | possibly_damaging(0.878) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SCMH1 | SNV | Missense_Mutation | rs762916876 | c.388C>T | p.Arg130Trp | p.R130W | Q96GD3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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