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Gene: SC5D |
Gene summary for SC5D |
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Gene information | Species | Human | Gene symbol | SC5D | Gene ID | 6309 |
Gene name | sterol-C5-desaturase | |
Gene Alias | ERG3 | |
Cytomap | 11q23.3-q24.1 | |
Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | A0A024R3G4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6309 | SC5D | LZE4T | Human | Esophagus | ESCC | 2.81e-23 | 6.85e-01 | 0.0811 |
6309 | SC5D | LZE7T | Human | Esophagus | ESCC | 1.02e-09 | 6.00e-01 | 0.0667 |
6309 | SC5D | LZE24T | Human | Esophagus | ESCC | 2.62e-19 | 5.02e-01 | 0.0596 |
6309 | SC5D | P1T-E | Human | Esophagus | ESCC | 7.91e-04 | 2.10e-01 | 0.0875 |
6309 | SC5D | P2T-E | Human | Esophagus | ESCC | 3.67e-20 | 3.09e-01 | 0.1177 |
6309 | SC5D | P4T-E | Human | Esophagus | ESCC | 3.54e-64 | 1.55e+00 | 0.1323 |
6309 | SC5D | P5T-E | Human | Esophagus | ESCC | 6.80e-40 | 8.69e-01 | 0.1327 |
6309 | SC5D | P8T-E | Human | Esophagus | ESCC | 7.82e-22 | 3.82e-01 | 0.0889 |
6309 | SC5D | P9T-E | Human | Esophagus | ESCC | 3.62e-32 | 7.81e-01 | 0.1131 |
6309 | SC5D | P10T-E | Human | Esophagus | ESCC | 2.91e-37 | 6.70e-01 | 0.116 |
6309 | SC5D | P11T-E | Human | Esophagus | ESCC | 2.84e-11 | 5.99e-01 | 0.1426 |
6309 | SC5D | P12T-E | Human | Esophagus | ESCC | 8.36e-43 | 8.52e-01 | 0.1122 |
6309 | SC5D | P15T-E | Human | Esophagus | ESCC | 2.87e-19 | 4.49e-01 | 0.1149 |
6309 | SC5D | P16T-E | Human | Esophagus | ESCC | 3.25e-29 | 4.82e-01 | 0.1153 |
6309 | SC5D | P17T-E | Human | Esophagus | ESCC | 8.86e-04 | 1.53e-01 | 0.1278 |
6309 | SC5D | P19T-E | Human | Esophagus | ESCC | 3.07e-02 | 1.97e-01 | 0.1662 |
6309 | SC5D | P20T-E | Human | Esophagus | ESCC | 3.90e-13 | 1.88e-01 | 0.1124 |
6309 | SC5D | P21T-E | Human | Esophagus | ESCC | 9.82e-30 | 5.75e-01 | 0.1617 |
6309 | SC5D | P22T-E | Human | Esophagus | ESCC | 1.51e-29 | 5.67e-01 | 0.1236 |
6309 | SC5D | P23T-E | Human | Esophagus | ESCC | 6.22e-18 | 5.40e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:00161263 | Esophagus | ESCC | sterol biosynthetic process | 46/8552 | 64/18723 | 1.91e-05 | 1.67e-04 | 46 |
GO:00066953 | Esophagus | ESCC | cholesterol biosynthetic process | 41/8552 | 57/18723 | 5.25e-05 | 4.06e-04 | 41 |
GO:19026533 | Esophagus | ESCC | secondary alcohol biosynthetic process | 41/8552 | 57/18723 | 5.25e-05 | 4.06e-04 | 41 |
GO:19026524 | Esophagus | ESCC | secondary alcohol metabolic process | 87/8552 | 147/18723 | 6.58e-04 | 3.50e-03 | 87 |
GO:00461653 | Esophagus | ESCC | alcohol biosynthetic process | 83/8552 | 140/18723 | 8.04e-04 | 4.16e-03 | 83 |
GO:00066946 | Esophagus | ESCC | steroid biosynthetic process | 98/8552 | 173/18723 | 2.34e-03 | 1.03e-02 | 98 |
GO:00082034 | Esophagus | ESCC | cholesterol metabolic process | 79/8552 | 137/18723 | 3.11e-03 | 1.29e-02 | 79 |
GO:00161254 | Esophagus | ESCC | sterol metabolic process | 86/8552 | 152/18723 | 4.37e-03 | 1.73e-02 | 86 |
GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
GO:000606621 | Liver | HCC | alcohol metabolic process | 208/7958 | 353/18723 | 2.80e-10 | 9.50e-09 | 208 |
GO:19026522 | Liver | HCC | secondary alcohol metabolic process | 100/7958 | 147/18723 | 3.26e-10 | 1.09e-08 | 100 |
GO:00082032 | Liver | HCC | cholesterol metabolic process | 94/7958 | 137/18723 | 5.39e-10 | 1.72e-08 | 94 |
GO:00082022 | Liver | HCC | steroid metabolic process | 188/7958 | 319/18723 | 1.96e-09 | 5.63e-08 | 188 |
GO:00161252 | Liver | HCC | sterol metabolic process | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:00066951 | Liver | HCC | cholesterol biosynthetic process | 43/7958 | 57/18723 | 4.37e-07 | 7.23e-06 | 43 |
GO:19026531 | Liver | HCC | secondary alcohol biosynthetic process | 43/7958 | 57/18723 | 4.37e-07 | 7.23e-06 | 43 |
GO:00161261 | Liver | HCC | sterol biosynthetic process | 47/7958 | 64/18723 | 5.00e-07 | 8.11e-06 | 47 |
GO:00066942 | Liver | HCC | steroid biosynthetic process | 104/7958 | 173/18723 | 2.13e-06 | 2.91e-05 | 104 |
GO:19016172 | Liver | HCC | organic hydroxy compound biosynthetic process | 129/7958 | 237/18723 | 1.32e-04 | 1.08e-03 | 129 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa001005 | Esophagus | ESCC | Steroid biosynthesis | 18/4205 | 20/8465 | 1.78e-04 | 6.79e-04 | 3.48e-04 | 18 |
hsa0010012 | Esophagus | ESCC | Steroid biosynthesis | 18/4205 | 20/8465 | 1.78e-04 | 6.79e-04 | 3.48e-04 | 18 |
hsa001002 | Liver | HCC | Steroid biosynthesis | 15/4020 | 20/8465 | 1.17e-02 | 2.97e-02 | 1.65e-02 | 15 |
hsa001003 | Liver | HCC | Steroid biosynthesis | 15/4020 | 20/8465 | 1.17e-02 | 2.97e-02 | 1.65e-02 | 15 |
hsa001004 | Oral cavity | OSCC | Steroid biosynthesis | 15/3704 | 20/8465 | 4.62e-03 | 1.13e-02 | 5.75e-03 | 15 |
hsa0010011 | Oral cavity | OSCC | Steroid biosynthesis | 15/3704 | 20/8465 | 4.62e-03 | 1.13e-02 | 5.75e-03 | 15 |
hsa0010021 | Oral cavity | LP | Steroid biosynthesis | 11/2418 | 20/8465 | 1.16e-02 | 3.91e-02 | 2.52e-02 | 11 |
hsa0010031 | Oral cavity | LP | Steroid biosynthesis | 11/2418 | 20/8465 | 1.16e-02 | 3.91e-02 | 2.52e-02 | 11 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SC5D | SNV | Missense_Mutation | novel | c.13C>A | p.Leu5Ile | p.L5I | O75845 | protein_coding | deleterious(0) | benign(0.232) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SC5D | SNV | Missense_Mutation | novel | c.17N>T | p.Arg6Leu | p.R6L | O75845 | protein_coding | deleterious(0.03) | benign(0) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SC5D | SNV | Missense_Mutation | rs104894295 | c.86G>A | p.Arg29Gln | p.R29Q | O75845 | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SC5D | insertion | Frame_Shift_Ins | novel | c.377_378insCATCATAGGGGTTCAAGAA | p.Leu127IlefsTer11 | p.L127Ifs*11 | O75845 | protein_coding | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SC5D | SNV | Missense_Mutation | novel | c.551N>A | p.Pro184His | p.P184H | O75845 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
SC5D | SNV | Missense_Mutation | novel | c.593N>T | p.Tyr198Phe | p.Y198F | O75845 | protein_coding | tolerated(1) | benign(0.003) | TCGA-44-6145-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SC5D | SNV | Missense_Mutation | c.49N>T | p.Val17Leu | p.V17L | O75845 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
SC5D | SNV | Missense_Mutation | rs781370638 | c.56C>T | p.Pro19Leu | p.P19L | O75845 | protein_coding | tolerated(0.16) | benign(0.009) | TCGA-73-4677-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SC5D | SNV | Missense_Mutation | novel | c.626A>G | p.His209Arg | p.H209R | O75845 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
SC5D | SNV | Missense_Mutation | c.25N>C | p.Asp9His | p.D9H | O75845 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-91-6829-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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