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Gene: SBNO2 |
Gene summary for SBNO2 |
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Gene information | Species | Human | Gene symbol | SBNO2 | Gene ID | 22904 |
Gene name | strawberry notch homolog 2 | |
Gene Alias | KIAA0963 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000768 | UniProtAcc | Q9Y2G9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22904 | SBNO2 | LZE5T | Human | Esophagus | ESCC | 1.06e-03 | 1.55e-01 | 0.0514 |
22904 | SBNO2 | LZE8T | Human | Esophagus | ESCC | 1.82e-04 | 1.72e-01 | 0.067 |
22904 | SBNO2 | LZE24T | Human | Esophagus | ESCC | 1.53e-04 | 2.48e-02 | 0.0596 |
22904 | SBNO2 | LZE21T | Human | Esophagus | ESCC | 5.08e-04 | 1.75e-01 | 0.0655 |
22904 | SBNO2 | P2T-E | Human | Esophagus | ESCC | 1.45e-10 | 2.33e-02 | 0.1177 |
22904 | SBNO2 | P4T-E | Human | Esophagus | ESCC | 4.95e-08 | 3.84e-02 | 0.1323 |
22904 | SBNO2 | P5T-E | Human | Esophagus | ESCC | 4.99e-04 | 4.39e-02 | 0.1327 |
22904 | SBNO2 | P8T-E | Human | Esophagus | ESCC | 4.37e-09 | 2.31e-01 | 0.0889 |
22904 | SBNO2 | P9T-E | Human | Esophagus | ESCC | 5.57e-05 | 1.09e-01 | 0.1131 |
22904 | SBNO2 | P10T-E | Human | Esophagus | ESCC | 5.24e-09 | 9.91e-02 | 0.116 |
22904 | SBNO2 | P11T-E | Human | Esophagus | ESCC | 1.93e-04 | 2.64e-01 | 0.1426 |
22904 | SBNO2 | P15T-E | Human | Esophagus | ESCC | 2.13e-03 | 5.01e-02 | 0.1149 |
22904 | SBNO2 | P16T-E | Human | Esophagus | ESCC | 5.78e-05 | 4.03e-02 | 0.1153 |
22904 | SBNO2 | P17T-E | Human | Esophagus | ESCC | 1.25e-03 | 2.05e-01 | 0.1278 |
22904 | SBNO2 | P20T-E | Human | Esophagus | ESCC | 3.24e-09 | 6.52e-02 | 0.1124 |
22904 | SBNO2 | P21T-E | Human | Esophagus | ESCC | 1.63e-15 | 1.77e-01 | 0.1617 |
22904 | SBNO2 | P22T-E | Human | Esophagus | ESCC | 2.71e-09 | -2.68e-02 | 0.1236 |
22904 | SBNO2 | P23T-E | Human | Esophagus | ESCC | 2.15e-06 | 3.13e-01 | 0.108 |
22904 | SBNO2 | P24T-E | Human | Esophagus | ESCC | 5.75e-08 | 1.66e-01 | 0.1287 |
22904 | SBNO2 | P26T-E | Human | Esophagus | ESCC | 1.80e-05 | -1.49e-02 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:000257317 | Esophagus | ESCC | myeloid leukocyte differentiation | 128/8552 | 208/18723 | 2.75e-06 | 3.15e-05 | 128 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:003249619 | Esophagus | ESCC | response to lipopolysaccharide | 191/8552 | 343/18723 | 1.11e-04 | 7.73e-04 | 191 |
GO:199082316 | Esophagus | ESCC | response to leukemia inhibitory factor | 60/8552 | 95/18723 | 4.41e-04 | 2.48e-03 | 60 |
GO:199083015 | Esophagus | ESCC | cellular response to leukemia inhibitory factor | 59/8552 | 94/18723 | 6.19e-04 | 3.32e-03 | 59 |
GO:000223719 | Esophagus | ESCC | response to molecule of bacterial origin | 194/8552 | 363/18723 | 1.64e-03 | 7.61e-03 | 194 |
GO:007122215 | Esophagus | ESCC | cellular response to lipopolysaccharide | 113/8552 | 209/18723 | 8.79e-03 | 3.10e-02 | 113 |
GO:007121617 | Esophagus | ESCC | cellular response to biotic stimulus | 131/8552 | 246/18723 | 9.85e-03 | 3.39e-02 | 131 |
GO:00303165 | Esophagus | ESCC | osteoclast differentiation | 54/8552 | 94/18723 | 1.43e-02 | 4.65e-02 | 54 |
GO:003009922 | Liver | HCC | myeloid cell differentiation | 200/7958 | 381/18723 | 4.64e-05 | 4.49e-04 | 200 |
GO:003249611 | Liver | HCC | response to lipopolysaccharide | 174/7958 | 343/18723 | 1.19e-03 | 6.62e-03 | 174 |
GO:00712166 | Liver | HCC | cellular response to biotic stimulus | 128/7958 | 246/18723 | 1.53e-03 | 8.10e-03 | 128 |
GO:00712226 | Liver | HCC | cellular response to lipopolysaccharide | 110/7958 | 209/18723 | 1.92e-03 | 9.77e-03 | 110 |
GO:000223711 | Liver | HCC | response to molecule of bacterial origin | 181/7958 | 363/18723 | 2.58e-03 | 1.24e-02 | 181 |
GO:00712196 | Liver | HCC | cellular response to molecule of bacterial origin | 113/7958 | 221/18723 | 5.73e-03 | 2.38e-02 | 113 |
GO:003009920 | Oral cavity | OSCC | myeloid cell differentiation | 213/7305 | 381/18723 | 1.24e-11 | 4.42e-10 | 213 |
GO:000257310 | Oral cavity | OSCC | myeloid leukocyte differentiation | 119/7305 | 208/18723 | 7.29e-08 | 1.29e-06 | 119 |
GO:003249617 | Oral cavity | OSCC | response to lipopolysaccharide | 178/7305 | 343/18723 | 7.27e-07 | 1.03e-05 | 178 |
GO:000150310 | Oral cavity | OSCC | ossification | 203/7305 | 408/18723 | 5.54e-06 | 6.19e-05 | 203 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SBNO2 | SNV | Missense_Mutation | rs774717752 | c.2911N>T | p.Arg971Cys | p.R971C | Q9Y2G9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
SBNO2 | SNV | Missense_Mutation | c.1922N>C | p.Leu641Pro | p.L641P | Q9Y2G9 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
SBNO2 | SNV | Missense_Mutation | c.1304N>A | p.Arg435His | p.R435H | Q9Y2G9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
SBNO2 | SNV | Missense_Mutation | rs774035034 | c.1246N>A | p.Val416Met | p.V416M | Q9Y2G9 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SBNO2 | SNV | Missense_Mutation | c.160N>A | p.Asp54Asn | p.D54N | Q9Y2G9 | protein_coding | tolerated_low_confidence(0.11) | benign(0.007) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SBNO2 | SNV | Missense_Mutation | rs371986032 | c.2974N>A | p.Asp992Asn | p.D992N | Q9Y2G9 | protein_coding | tolerated(0.13) | possibly_damaging(0.756) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
SBNO2 | SNV | Missense_Mutation | rs777055488 | c.985N>A | p.Ala329Thr | p.A329T | Q9Y2G9 | protein_coding | tolerated(0.09) | benign(0.36) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SBNO2 | SNV | Missense_Mutation | c.1261N>A | p.Ala421Thr | p.A421T | Q9Y2G9 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-D5-6923-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SBNO2 | SNV | Missense_Mutation | c.1432N>A | p.Ala478Thr | p.A478T | Q9Y2G9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SBNO2 | SNV | Missense_Mutation | rs765584534 | c.1880G>A | p.Arg627Gln | p.R627Q | Q9Y2G9 | protein_coding | tolerated(0.07) | probably_damaging(0.996) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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