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Gene: SBNO1 |
Gene summary for SBNO1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SBNO1 | Gene ID | 55206 |
Gene name | strawberry notch homolog 1 | |
Gene Alias | MOP3 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A3KN83 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55206 | SBNO1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.62e-04 | -2.86e-01 | 0.0155 |
55206 | SBNO1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.48e-04 | 4.05e-01 | -0.1954 |
55206 | SBNO1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.40e-04 | 9.91e-01 | 0.3487 |
55206 | SBNO1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.36e-05 | 6.22e-01 | 0.281 |
55206 | SBNO1 | A001-C-207 | Human | Colorectum | FAP | 4.28e-02 | -1.85e-01 | 0.1278 |
55206 | SBNO1 | A015-C-203 | Human | Colorectum | FAP | 9.90e-12 | -2.19e-01 | -0.1294 |
55206 | SBNO1 | A015-C-204 | Human | Colorectum | FAP | 2.72e-03 | -1.36e-01 | -0.0228 |
55206 | SBNO1 | A002-C-201 | Human | Colorectum | FAP | 1.87e-07 | -1.22e-01 | 0.0324 |
55206 | SBNO1 | A001-C-108 | Human | Colorectum | FAP | 1.02e-04 | 3.08e-02 | -0.0272 |
55206 | SBNO1 | A002-C-205 | Human | Colorectum | FAP | 2.53e-10 | -2.13e-02 | -0.1236 |
55206 | SBNO1 | A015-C-006 | Human | Colorectum | FAP | 2.88e-08 | 5.28e-02 | -0.0994 |
55206 | SBNO1 | A015-C-106 | Human | Colorectum | FAP | 1.16e-02 | -2.05e-03 | -0.0511 |
55206 | SBNO1 | A002-C-114 | Human | Colorectum | FAP | 4.09e-11 | -2.65e-01 | -0.1561 |
55206 | SBNO1 | A015-C-104 | Human | Colorectum | FAP | 3.94e-12 | -1.13e-01 | -0.1899 |
55206 | SBNO1 | A001-C-014 | Human | Colorectum | FAP | 1.35e-04 | -8.35e-02 | 0.0135 |
55206 | SBNO1 | A002-C-016 | Human | Colorectum | FAP | 7.38e-10 | -1.58e-01 | 0.0521 |
55206 | SBNO1 | A015-C-002 | Human | Colorectum | FAP | 2.19e-06 | -2.01e-01 | -0.0763 |
55206 | SBNO1 | A002-C-116 | Human | Colorectum | FAP | 1.09e-15 | -1.20e-01 | -0.0452 |
55206 | SBNO1 | A014-C-008 | Human | Colorectum | FAP | 9.28e-06 | -1.01e-01 | -0.191 |
55206 | SBNO1 | A018-E-020 | Human | Colorectum | FAP | 1.79e-11 | -2.14e-01 | -0.2034 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SBNO1 | SNV | Missense_Mutation | c.2665G>A | p.Glu889Lys | p.E889K | A3KN83 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
SBNO1 | SNV | Missense_Mutation | c.3150G>A | p.Met1050Ile | p.M1050I | A3KN83 | protein_coding | deleterious(0.03) | benign(0.444) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SBNO1 | SNV | Missense_Mutation | c.2914G>A | p.Asp972Asn | p.D972N | A3KN83 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SBNO1 | SNV | Missense_Mutation | novel | c.3593N>C | p.Leu1198Pro | p.L1198P | A3KN83 | protein_coding | tolerated(0.18) | benign(0.121) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SBNO1 | SNV | Missense_Mutation | c.3607N>A | p.Asp1203Asn | p.D1203N | A3KN83 | protein_coding | deleterious(0.02) | possibly_damaging(0.716) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SBNO1 | SNV | Missense_Mutation | c.1149A>C | p.Lys383Asn | p.K383N | A3KN83 | protein_coding | deleterious(0) | possibly_damaging(0.8) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SBNO1 | SNV | Missense_Mutation | c.2938N>T | p.Arg980Cys | p.R980C | A3KN83 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3688-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SBNO1 | SNV | Missense_Mutation | c.989N>T | p.Thr330Met | p.T330M | A3KN83 | protein_coding | deleterious(0) | possibly_damaging(0.817) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SBNO1 | SNV | Missense_Mutation | c.2780N>A | p.Arg927Gln | p.R927Q | A3KN83 | protein_coding | tolerated(0.05) | possibly_damaging(0.864) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SBNO1 | SNV | Missense_Mutation | c.4006N>T | p.Arg1336Trp | p.R1336W | A3KN83 | protein_coding | deleterious(0) | possibly_damaging(0.548) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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