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Gene: SAP30BP |
Gene summary for SAP30BP |
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Gene information | Species | Human | Gene symbol | SAP30BP | Gene ID | 29115 |
Gene name | SAP30 binding protein | |
Gene Alias | HCNGP | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9UHR5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29115 | SAP30BP | LZE4T | Human | Esophagus | ESCC | 5.47e-17 | 4.51e-01 | 0.0811 |
29115 | SAP30BP | LZE5T | Human | Esophagus | ESCC | 9.60e-03 | 3.21e-01 | 0.0514 |
29115 | SAP30BP | LZE7T | Human | Esophagus | ESCC | 7.81e-06 | 5.44e-01 | 0.0667 |
29115 | SAP30BP | LZE8T | Human | Esophagus | ESCC | 4.79e-07 | 2.50e-01 | 0.067 |
29115 | SAP30BP | LZE20T | Human | Esophagus | ESCC | 3.71e-08 | 8.82e-02 | 0.0662 |
29115 | SAP30BP | LZE22T | Human | Esophagus | ESCC | 4.18e-10 | 5.44e-01 | 0.068 |
29115 | SAP30BP | LZE24T | Human | Esophagus | ESCC | 1.80e-24 | 7.54e-01 | 0.0596 |
29115 | SAP30BP | LZE21T | Human | Esophagus | ESCC | 5.28e-07 | 5.32e-01 | 0.0655 |
29115 | SAP30BP | LZE6T | Human | Esophagus | ESCC | 1.16e-15 | 3.36e-01 | 0.0845 |
29115 | SAP30BP | P1T-E | Human | Esophagus | ESCC | 4.66e-10 | 4.76e-01 | 0.0875 |
29115 | SAP30BP | P2T-E | Human | Esophagus | ESCC | 5.88e-46 | 6.86e-01 | 0.1177 |
29115 | SAP30BP | P4T-E | Human | Esophagus | ESCC | 9.47e-15 | 3.04e-01 | 0.1323 |
29115 | SAP30BP | P5T-E | Human | Esophagus | ESCC | 1.44e-18 | 3.54e-01 | 0.1327 |
29115 | SAP30BP | P8T-E | Human | Esophagus | ESCC | 2.22e-42 | 6.19e-01 | 0.0889 |
29115 | SAP30BP | P9T-E | Human | Esophagus | ESCC | 1.54e-25 | 4.38e-01 | 0.1131 |
29115 | SAP30BP | P10T-E | Human | Esophagus | ESCC | 1.94e-47 | 8.63e-01 | 0.116 |
29115 | SAP30BP | P11T-E | Human | Esophagus | ESCC | 7.19e-33 | 1.01e+00 | 0.1426 |
29115 | SAP30BP | P12T-E | Human | Esophagus | ESCC | 3.93e-40 | 7.65e-01 | 0.1122 |
29115 | SAP30BP | P15T-E | Human | Esophagus | ESCC | 3.89e-34 | 6.97e-01 | 0.1149 |
29115 | SAP30BP | P16T-E | Human | Esophagus | ESCC | 5.11e-22 | 3.70e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:0044403111 | Esophagus | ESCC | biological process involved in symbiotic interaction | 186/8552 | 290/18723 | 1.43e-10 | 4.16e-09 | 186 |
GO:003105614 | Esophagus | ESCC | regulation of histone modification | 106/8552 | 152/18723 | 1.52e-09 | 3.55e-08 | 106 |
GO:00356015 | Esophagus | ESCC | protein deacylation | 79/8552 | 112/18723 | 8.30e-08 | 1.42e-06 | 79 |
GO:00987325 | Esophagus | ESCC | macromolecule deacylation | 80/8552 | 116/18723 | 3.19e-07 | 4.50e-06 | 80 |
GO:00165754 | Esophagus | ESCC | histone deacetylation | 60/8552 | 82/18723 | 3.85e-07 | 5.32e-06 | 60 |
GO:00310583 | Esophagus | ESCC | positive regulation of histone modification | 65/8552 | 92/18723 | 1.04e-06 | 1.31e-05 | 65 |
GO:00064765 | Esophagus | ESCC | protein deacetylation | 70/8552 | 101/18723 | 1.29e-06 | 1.58e-05 | 70 |
GO:005185115 | Esophagus | ESCC | modulation by host of symbiont process | 43/8552 | 60/18723 | 4.00e-05 | 3.22e-04 | 43 |
GO:005181714 | Esophagus | ESCC | modulation of process of other organism involved in symbiotic interaction | 54/8552 | 81/18723 | 1.09e-04 | 7.64e-04 | 54 |
GO:00903122 | Esophagus | ESCC | positive regulation of protein deacetylation | 20/8552 | 25/18723 | 4.81e-04 | 2.69e-03 | 20 |
GO:003582114 | Esophagus | ESCC | modulation of process of other organism | 64/8552 | 106/18723 | 1.61e-03 | 7.50e-03 | 64 |
GO:005170214 | Esophagus | ESCC | biological process involved in interaction with symbiont | 57/8552 | 94/18723 | 2.46e-03 | 1.07e-02 | 57 |
GO:00310652 | Esophagus | ESCC | positive regulation of histone deacetylation | 15/8552 | 19/18723 | 3.29e-03 | 1.35e-02 | 15 |
GO:00310631 | Esophagus | ESCC | regulation of histone deacetylation | 21/8552 | 31/18723 | 1.10e-02 | 3.70e-02 | 21 |
GO:00903114 | Esophagus | ESCC | regulation of protein deacetylation | 30/8552 | 48/18723 | 1.40e-02 | 4.57e-02 | 30 |
GO:004440312 | Liver | Cirrhotic | biological process involved in symbiotic interaction | 131/4634 | 290/18723 | 2.00e-14 | 1.84e-12 | 131 |
GO:00518171 | Liver | Cirrhotic | modulation of process of other organism involved in symbiotic interaction | 44/4634 | 81/18723 | 1.11e-08 | 4.26e-07 | 44 |
GO:005170211 | Liver | Cirrhotic | biological process involved in interaction with symbiont | 48/4634 | 94/18723 | 3.41e-08 | 1.14e-06 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SAP30BP | SNV | Missense_Mutation | novel | c.175N>C | p.Asp59His | p.D59H | Q9UHR5 | protein_coding | deleterious_low_confidence(0) | benign(0.259) | TCGA-QK-A6II-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
SAP30BP | SNV | Missense_Mutation | c.578A>G | p.Glu193Gly | p.E193G | Q9UHR5 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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