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Gene: SAP130 |
Gene summary for SAP130 |
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Gene information | Species | Human | Gene symbol | SAP130 | Gene ID | 79595 |
Gene name | Sin3A associated protein 130 | |
Gene Alias | SAP130 | |
Cytomap | 2q14.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9H0E3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79595 | SAP130 | HCC1_Meng | Human | Liver | HCC | 3.94e-17 | -5.59e-04 | 0.0246 |
79595 | SAP130 | HCC1 | Human | Liver | HCC | 1.70e-03 | 2.99e+00 | 0.5336 |
79595 | SAP130 | HCC2 | Human | Liver | HCC | 1.18e-07 | 3.08e+00 | 0.5341 |
79595 | SAP130 | S014 | Human | Liver | HCC | 2.96e-07 | 2.64e-01 | 0.2254 |
79595 | SAP130 | S015 | Human | Liver | HCC | 8.77e-05 | 2.91e-01 | 0.2375 |
79595 | SAP130 | S016 | Human | Liver | HCC | 5.36e-08 | 2.75e-01 | 0.2243 |
79595 | SAP130 | S027 | Human | Liver | HCC | 1.68e-03 | 3.71e-01 | 0.2446 |
79595 | SAP130 | S028 | Human | Liver | HCC | 1.18e-09 | 4.05e-01 | 0.2503 |
79595 | SAP130 | S029 | Human | Liver | HCC | 1.51e-03 | 2.65e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SAP130 | SNV | Missense_Mutation | rs147076612 | c.1354N>A | p.Glu452Lys | p.E452K | Q9H0E3 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.805) | TCGA-D5-5541-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | calcium | SD |
SAP130 | SNV | Missense_Mutation | c.2048G>A | p.Arg683Gln | p.R683Q | Q9H0E3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.99) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
SAP130 | SNV | Missense_Mutation | rs139785439 | c.1000N>T | p.Arg334Cys | p.R334C | Q9H0E3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SAP130 | insertion | Frame_Shift_Ins | novel | c.2600_2601insC | p.Arg868LysfsTer17 | p.R868Kfs*17 | Q9H0E3 | protein_coding | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SAP130 | insertion | Frame_Shift_Ins | novel | c.3219dupA | p.Val1074SerfsTer26 | p.V1074Sfs*26 | Q9H0E3 | protein_coding | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SAP130 | SNV | Missense_Mutation | c.2902N>G | p.Ile968Val | p.I968V | Q9H0E3 | protein_coding | tolerated_low_confidence(0.47) | benign(0.007) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SAP130 | SNV | Missense_Mutation | novel | c.2353A>G | p.Ile785Val | p.I785V | Q9H0E3 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SAP130 | SNV | Missense_Mutation | novel | c.859C>A | p.Pro287Thr | p.P287T | Q9H0E3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SAP130 | SNV | Missense_Mutation | novel | c.1018N>C | p.Asp340His | p.D340H | Q9H0E3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AJ-A3QS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
SAP130 | SNV | Missense_Mutation | c.988N>C | p.Ile330Leu | p.I330L | Q9H0E3 | protein_coding | tolerated_low_confidence(0.22) | benign(0.12) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
79595 | SAP130 | NA | SPLICEOSTATIN-A | CHEMBL1221944 | 17643111 |
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