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Gene: SAMD12 |
Gene summary for SAMD12 |
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Gene information | Species | Human | Gene symbol | SAMD12 | Gene ID | 401474 |
Gene name | sterile alpha motif domain containing 12 | |
Gene Alias | SAMD12 | |
Cytomap | 8q24.11-q24.12 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | B8ZZB7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401474 | SAMD12 | CCI_1 | Human | Cervix | CC | 9.78e-05 | 5.82e-01 | 0.528 |
401474 | SAMD12 | CCI_2 | Human | Cervix | CC | 2.24e-08 | 1.49e+00 | 0.5249 |
401474 | SAMD12 | CCI_3 | Human | Cervix | CC | 2.03e-21 | 1.31e+00 | 0.516 |
401474 | SAMD12 | H2 | Human | Cervix | HSIL_HPV | 3.53e-05 | 2.27e-01 | 0.0632 |
401474 | SAMD12 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.27e-63 | -1.01e+00 | 0.0155 |
401474 | SAMD12 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.17e-20 | -8.70e-01 | -0.1808 |
401474 | SAMD12 | HTA11_2951_2000001011 | Human | Colorectum | AD | 8.55e-16 | -1.25e+00 | 0.0216 |
401474 | SAMD12 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.99e-05 | -5.25e-01 | -0.0811 |
401474 | SAMD12 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.41e-03 | -4.95e-01 | -0.2602 |
401474 | SAMD12 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.42e-07 | -8.37e-01 | -0.2196 |
401474 | SAMD12 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.92e-30 | -1.10e+00 | -0.1207 |
401474 | SAMD12 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.20e-04 | -4.64e-01 | -0.1526 |
401474 | SAMD12 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.51e-24 | -6.13e-01 | -0.1464 |
401474 | SAMD12 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.64e-11 | -5.81e-01 | -0.1001 |
401474 | SAMD12 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.01e-03 | -5.61e-01 | -0.1706 |
401474 | SAMD12 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.66e-13 | -9.57e-01 | -0.2061 |
401474 | SAMD12 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.93e-11 | -8.86e-01 | -0.1462 |
401474 | SAMD12 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.27e-05 | -5.54e-01 | -0.0842 |
401474 | SAMD12 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.23e-06 | -9.99e-01 | -0.00410000000000005 |
401474 | SAMD12 | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.37e-19 | -9.29e-01 | -0.0179 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SAMD12 | SNV | Missense_Mutation | c.380N>G | p.Glu127Gly | p.E127G | Q8N8I0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-66-2759-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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