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Gene: SAFB2 |
Gene summary for SAFB2 |
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Gene information | Species | Human | Gene symbol | SAFB2 | Gene ID | 9667 |
Gene name | scaffold attachment factor B2 | |
Gene Alias | SAFB2 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q14151 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9667 | SAFB2 | LZE4T | Human | Esophagus | ESCC | 9.90e-10 | 3.58e-01 | 0.0811 |
9667 | SAFB2 | LZE7T | Human | Esophagus | ESCC | 2.14e-17 | 7.93e-01 | 0.0667 |
9667 | SAFB2 | LZE8T | Human | Esophagus | ESCC | 1.45e-08 | 2.05e-01 | 0.067 |
9667 | SAFB2 | LZE20T | Human | Esophagus | ESCC | 3.30e-04 | 1.70e-01 | 0.0662 |
9667 | SAFB2 | LZE24T | Human | Esophagus | ESCC | 1.41e-17 | 4.40e-01 | 0.0596 |
9667 | SAFB2 | LZE6T | Human | Esophagus | ESCC | 1.39e-02 | 2.22e-01 | 0.0845 |
9667 | SAFB2 | P1T-E | Human | Esophagus | ESCC | 2.09e-08 | 5.10e-01 | 0.0875 |
9667 | SAFB2 | P2T-E | Human | Esophagus | ESCC | 1.13e-23 | 3.84e-01 | 0.1177 |
9667 | SAFB2 | P4T-E | Human | Esophagus | ESCC | 6.14e-31 | 7.59e-01 | 0.1323 |
9667 | SAFB2 | P5T-E | Human | Esophagus | ESCC | 6.56e-18 | 5.60e-01 | 0.1327 |
9667 | SAFB2 | P8T-E | Human | Esophagus | ESCC | 1.73e-21 | 5.31e-01 | 0.0889 |
9667 | SAFB2 | P9T-E | Human | Esophagus | ESCC | 5.26e-17 | 5.47e-01 | 0.1131 |
9667 | SAFB2 | P10T-E | Human | Esophagus | ESCC | 2.74e-32 | 7.33e-01 | 0.116 |
9667 | SAFB2 | P11T-E | Human | Esophagus | ESCC | 4.62e-11 | 5.20e-01 | 0.1426 |
9667 | SAFB2 | P12T-E | Human | Esophagus | ESCC | 4.61e-28 | 6.12e-01 | 0.1122 |
9667 | SAFB2 | P15T-E | Human | Esophagus | ESCC | 2.06e-23 | 5.34e-01 | 0.1149 |
9667 | SAFB2 | P16T-E | Human | Esophagus | ESCC | 5.61e-17 | 3.46e-01 | 0.1153 |
9667 | SAFB2 | P17T-E | Human | Esophagus | ESCC | 8.62e-09 | 2.83e-01 | 0.1278 |
9667 | SAFB2 | P19T-E | Human | Esophagus | ESCC | 2.52e-06 | 5.65e-01 | 0.1662 |
9667 | SAFB2 | P20T-E | Human | Esophagus | ESCC | 2.27e-22 | 5.26e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903311110 | Esophagus | ESCC | regulation of mRNA metabolic process | 210/8552 | 288/18723 | 3.25e-21 | 5.56e-19 | 210 |
GO:0050684110 | Esophagus | ESCC | regulation of mRNA processing | 109/8552 | 137/18723 | 3.51e-16 | 2.59e-14 | 109 |
GO:0030522110 | Esophagus | ESCC | intracellular receptor signaling pathway | 170/8552 | 265/18723 | 8.58e-10 | 2.09e-08 | 170 |
GO:0048545111 | Esophagus | ESCC | response to steroid hormone | 204/8552 | 339/18723 | 4.47e-08 | 8.11e-07 | 204 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:0071383110 | Esophagus | ESCC | cellular response to steroid hormone stimulus | 127/8552 | 204/18723 | 1.26e-06 | 1.55e-05 | 127 |
GO:003051819 | Esophagus | ESCC | intracellular steroid hormone receptor signaling pathway | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
GO:004340119 | Esophagus | ESCC | steroid hormone mediated signaling pathway | 87/8552 | 136/18723 | 1.25e-05 | 1.15e-04 | 87 |
GO:00331438 | Esophagus | ESCC | regulation of intracellular steroid hormone receptor signaling pathway | 50/8552 | 74/18723 | 1.16e-04 | 8.04e-04 | 50 |
GO:003052118 | Esophagus | ESCC | androgen receptor signaling pathway | 31/8552 | 44/18723 | 7.70e-04 | 3.99e-03 | 31 |
GO:000975516 | Esophagus | ESCC | hormone-mediated signaling pathway | 106/8552 | 190/18723 | 3.13e-03 | 1.30e-02 | 106 |
GO:00607655 | Esophagus | ESCC | regulation of androgen receptor signaling pathway | 20/8552 | 28/18723 | 5.23e-03 | 1.97e-02 | 20 |
GO:190331111 | Liver | Cirrhotic | regulation of mRNA metabolic process | 140/4634 | 288/18723 | 1.07e-18 | 1.91e-16 | 140 |
GO:005068411 | Liver | Cirrhotic | regulation of mRNA processing | 81/4634 | 137/18723 | 1.05e-17 | 1.60e-15 | 81 |
GO:004854512 | Liver | Cirrhotic | response to steroid hormone | 146/4634 | 339/18723 | 7.87e-14 | 6.76e-12 | 146 |
GO:007138312 | Liver | Cirrhotic | cellular response to steroid hormone stimulus | 90/4634 | 204/18723 | 1.04e-09 | 4.70e-08 | 90 |
GO:003052212 | Liver | Cirrhotic | intracellular receptor signaling pathway | 105/4634 | 265/18723 | 5.44e-08 | 1.69e-06 | 105 |
GO:004340111 | Liver | Cirrhotic | steroid hormone mediated signaling pathway | 58/4634 | 136/18723 | 3.44e-06 | 5.95e-05 | 58 |
GO:003051811 | Liver | Cirrhotic | intracellular steroid hormone receptor signaling pathway | 50/4634 | 116/18723 | 1.11e-05 | 1.59e-04 | 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SAFB2 | SNV | Missense_Mutation | rs779380222 | c.1871N>C | p.Glu624Ala | p.E624A | Q14151 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SAFB2 | SNV | Missense_Mutation | c.1443N>T | p.Glu481Asp | p.E481D | Q14151 | protein_coding | deleterious(0) | benign(0.22) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SAFB2 | SNV | Missense_Mutation | rs547264084 | c.2264N>A | p.Arg755His | p.R755H | Q14151 | protein_coding | tolerated(0.57) | benign(0.003) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SAFB2 | SNV | Missense_Mutation | c.1328N>A | p.Arg443His | p.R443H | Q14151 | protein_coding | deleterious(0.01) | benign(0.239) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SAFB2 | SNV | Missense_Mutation | c.419N>T | p.Ala140Val | p.A140V | Q14151 | protein_coding | deleterious(0) | benign(0.02) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SAFB2 | SNV | Missense_Mutation | c.492N>C | p.Glu164Asp | p.E164D | Q14151 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-NH-A6GA-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | PD | |
SAFB2 | SNV | Missense_Mutation | novel | c.1525N>A | p.Asp509Asn | p.D509N | Q14151 | protein_coding | deleterious(0.02) | benign(0.415) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SAFB2 | deletion | Frame_Shift_Del | c.2508delG | p.Leu837CysfsTer18 | p.L837Cfs*18 | Q14151 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
SAFB2 | deletion | Frame_Shift_Del | rs765699897 | c.2471delN | p.Gly824AlafsTer8 | p.G824Afs*8 | Q14151 | protein_coding | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | ||
SAFB2 | deletion | Frame_Shift_Del | novel | c.2516delN | p.Pro839LeufsTer16 | p.P839Lfs*16 | Q14151 | protein_coding | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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