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Gene: RUFY3 |
Gene summary for RUFY3 |
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Gene information | Species | Human | Gene symbol | RUFY3 | Gene ID | 22902 |
Gene name | RUN and FYVE domain containing 3 | |
Gene Alias | RIPX | |
Cytomap | 4q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q7L099 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22902 | RUFY3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.08e-03 | -3.14e-01 | 0.294 |
22902 | RUFY3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.98e-06 | -3.53e-01 | 0.3005 |
22902 | RUFY3 | A015-C-203 | Human | Colorectum | FAP | 6.31e-20 | -2.94e-01 | -0.1294 |
22902 | RUFY3 | A015-C-204 | Human | Colorectum | FAP | 3.20e-04 | -3.30e-01 | -0.0228 |
22902 | RUFY3 | A014-C-040 | Human | Colorectum | FAP | 2.93e-04 | -5.25e-01 | -0.1184 |
22902 | RUFY3 | A002-C-201 | Human | Colorectum | FAP | 5.83e-10 | -3.09e-01 | 0.0324 |
22902 | RUFY3 | A001-C-119 | Human | Colorectum | FAP | 6.55e-03 | -2.96e-01 | -0.1557 |
22902 | RUFY3 | A001-C-108 | Human | Colorectum | FAP | 3.99e-08 | -1.76e-01 | -0.0272 |
22902 | RUFY3 | A002-C-205 | Human | Colorectum | FAP | 2.37e-15 | -2.11e-01 | -0.1236 |
22902 | RUFY3 | A015-C-006 | Human | Colorectum | FAP | 3.74e-12 | -3.86e-01 | -0.0994 |
22902 | RUFY3 | A015-C-106 | Human | Colorectum | FAP | 3.95e-09 | -2.47e-01 | -0.0511 |
22902 | RUFY3 | A002-C-114 | Human | Colorectum | FAP | 5.28e-12 | -2.81e-01 | -0.1561 |
22902 | RUFY3 | A015-C-104 | Human | Colorectum | FAP | 1.72e-17 | -3.08e-01 | -0.1899 |
22902 | RUFY3 | A001-C-014 | Human | Colorectum | FAP | 5.27e-11 | -2.80e-01 | 0.0135 |
22902 | RUFY3 | A002-C-016 | Human | Colorectum | FAP | 6.88e-14 | -3.01e-01 | 0.0521 |
22902 | RUFY3 | A015-C-002 | Human | Colorectum | FAP | 2.49e-07 | -3.54e-01 | -0.0763 |
22902 | RUFY3 | A001-C-203 | Human | Colorectum | FAP | 5.71e-07 | -2.03e-01 | -0.0481 |
22902 | RUFY3 | A002-C-116 | Human | Colorectum | FAP | 9.48e-21 | -2.68e-01 | -0.0452 |
22902 | RUFY3 | A014-C-008 | Human | Colorectum | FAP | 3.03e-11 | -4.31e-01 | -0.191 |
22902 | RUFY3 | A018-E-020 | Human | Colorectum | FAP | 7.97e-13 | -2.73e-01 | -0.2034 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070152 | Colorectum | MSS | actin filament organization | 146/3467 | 442/18723 | 1.16e-13 | 2.67e-11 | 146 |
GO:00325352 | Colorectum | MSS | regulation of cellular component size | 127/3467 | 383/18723 | 3.44e-12 | 5.79e-10 | 127 |
GO:19049512 | Colorectum | MSS | positive regulation of establishment of protein localization | 110/3467 | 319/18723 | 6.30e-12 | 9.83e-10 | 110 |
GO:00512222 | Colorectum | MSS | positive regulation of protein transport | 104/3467 | 303/18723 | 3.23e-11 | 4.11e-09 | 104 |
GO:00903162 | Colorectum | MSS | positive regulation of intracellular protein transport | 60/3467 | 160/18723 | 1.18e-08 | 7.08e-07 | 60 |
GO:00323882 | Colorectum | MSS | positive regulation of intracellular transport | 70/3467 | 202/18723 | 3.32e-08 | 1.82e-06 | 70 |
GO:00331572 | Colorectum | MSS | regulation of intracellular protein transport | 76/3467 | 229/18723 | 7.03e-08 | 3.56e-06 | 76 |
GO:00323862 | Colorectum | MSS | regulation of intracellular transport | 102/3467 | 337/18723 | 9.73e-08 | 4.71e-06 | 102 |
GO:00071632 | Colorectum | MSS | establishment or maintenance of cell polarity | 72/3467 | 218/18723 | 1.90e-07 | 8.30e-06 | 72 |
GO:00300102 | Colorectum | MSS | establishment of cell polarity | 47/3467 | 143/18723 | 2.74e-05 | 5.58e-04 | 47 |
GO:00313462 | Colorectum | MSS | positive regulation of cell projection organization | 96/3467 | 353/18723 | 3.44e-05 | 6.70e-04 | 96 |
GO:00109752 | Colorectum | MSS | regulation of neuron projection development | 115/3467 | 445/18723 | 6.91e-05 | 1.20e-03 | 115 |
GO:00160492 | Colorectum | MSS | cell growth | 123/3467 | 482/18723 | 7.15e-05 | 1.21e-03 | 123 |
GO:00107202 | Colorectum | MSS | positive regulation of cell development | 81/3467 | 298/18723 | 1.38e-04 | 2.06e-03 | 81 |
GO:00015582 | Colorectum | MSS | regulation of cell growth | 105/3467 | 414/18723 | 2.97e-04 | 3.90e-03 | 105 |
GO:00313452 | Colorectum | MSS | negative regulation of cell projection organization | 54/3467 | 186/18723 | 3.03e-04 | 3.96e-03 | 54 |
GO:00507671 | Colorectum | MSS | regulation of neurogenesis | 94/3467 | 364/18723 | 3.12e-04 | 4.06e-03 | 94 |
GO:00074092 | Colorectum | MSS | axonogenesis | 105/3467 | 418/18723 | 4.32e-04 | 5.23e-03 | 105 |
GO:00615642 | Colorectum | MSS | axon development | 115/3467 | 467/18723 | 5.33e-04 | 6.00e-03 | 115 |
GO:00457731 | Colorectum | MSS | positive regulation of axon extension | 17/3467 | 42/18723 | 7.63e-04 | 8.10e-03 | 17 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RUFY3 | SNV | Missense_Mutation | c.65N>T | p.Ala22Val | p.A22V | Q7L099 | protein_coding | tolerated(0.16) | probably_damaging(0.99) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RUFY3 | SNV | Missense_Mutation | c.907N>G | p.Asn303Asp | p.N303D | Q7L099 | protein_coding | tolerated(0.12) | possibly_damaging(0.72) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RUFY3 | SNV | Missense_Mutation | c.578T>G | p.Phe193Cys | p.F193C | Q7L099 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AG-A02G-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PD | |
RUFY3 | SNV | Missense_Mutation | c.502C>T | p.Arg168Cys | p.R168C | Q7L099 | protein_coding | deleterious(0.01) | possibly_damaging(0.896) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RUFY3 | SNV | Missense_Mutation | novel | c.1178N>A | p.Ser393Tyr | p.S393Y | Q7L099 | protein_coding | deleterious(0) | possibly_damaging(0.735) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RUFY3 | SNV | Missense_Mutation | novel | c.784N>A | p.Asp262Asn | p.D262N | Q7L099 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A2QM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
RUFY3 | SNV | Missense_Mutation | novel | c.1038N>C | p.Arg346Ser | p.R346S | Q7L099 | protein_coding | tolerated(0.13) | benign(0.295) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RUFY3 | SNV | Missense_Mutation | novel | c.128N>A | p.Arg43Gln | p.R43Q | Q7L099 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RUFY3 | SNV | Missense_Mutation | rs200083075 | c.1342N>T | p.Arg448Cys | p.R448C | Q7L099 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RUFY3 | SNV | Missense_Mutation | novel | c.1723N>A | p.Val575Met | p.V575M | Q7L099 | protein_coding | deleterious(0.04) | benign(0.094) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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