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Gene: RSBN1L |
Gene summary for RSBN1L |
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Gene information | Species | Human | Gene symbol | RSBN1L | Gene ID | 222194 |
Gene name | round spermatid basic protein 1 like | |
Gene Alias | RSBN1L | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6PCB5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
222194 | RSBN1L | LZE2D | Human | Esophagus | HGIN | 1.28e-02 | 2.34e-01 | 0.0642 |
222194 | RSBN1L | LZE2T | Human | Esophagus | ESCC | 3.77e-05 | 6.56e-01 | 0.082 |
222194 | RSBN1L | LZE3D | Human | Esophagus | HGIN | 8.67e-04 | 8.71e-01 | 0.0668 |
222194 | RSBN1L | LZE4T | Human | Esophagus | ESCC | 2.29e-16 | 4.82e-01 | 0.0811 |
222194 | RSBN1L | LZE7T | Human | Esophagus | ESCC | 7.55e-17 | 9.59e-01 | 0.0667 |
222194 | RSBN1L | LZE8T | Human | Esophagus | ESCC | 9.21e-04 | 2.53e-01 | 0.067 |
222194 | RSBN1L | LZE20T | Human | Esophagus | ESCC | 1.53e-14 | 3.86e-01 | 0.0662 |
222194 | RSBN1L | LZE22D1 | Human | Esophagus | HGIN | 1.01e-10 | 4.21e-01 | 0.0595 |
222194 | RSBN1L | LZE22T | Human | Esophagus | ESCC | 2.45e-10 | 6.75e-01 | 0.068 |
222194 | RSBN1L | LZE24T | Human | Esophagus | ESCC | 5.64e-21 | 5.75e-01 | 0.0596 |
222194 | RSBN1L | LZE22D3 | Human | Esophagus | HGIN | 3.47e-04 | 5.17e-01 | 0.0653 |
222194 | RSBN1L | LZE21T | Human | Esophagus | ESCC | 2.86e-11 | 6.24e-01 | 0.0655 |
222194 | RSBN1L | LZE6T | Human | Esophagus | ESCC | 2.37e-08 | 2.52e-01 | 0.0845 |
222194 | RSBN1L | P1T-E | Human | Esophagus | ESCC | 1.15e-22 | 1.13e+00 | 0.0875 |
222194 | RSBN1L | P2T-E | Human | Esophagus | ESCC | 1.13e-51 | 9.26e-01 | 0.1177 |
222194 | RSBN1L | P4T-E | Human | Esophagus | ESCC | 1.96e-41 | 1.01e+00 | 0.1323 |
222194 | RSBN1L | P5T-E | Human | Esophagus | ESCC | 1.14e-33 | 5.66e-01 | 0.1327 |
222194 | RSBN1L | P8T-E | Human | Esophagus | ESCC | 1.25e-35 | 7.34e-01 | 0.0889 |
222194 | RSBN1L | P9T-E | Human | Esophagus | ESCC | 8.18e-39 | 9.43e-01 | 0.1131 |
222194 | RSBN1L | P10T-E | Human | Esophagus | ESCC | 6.77e-67 | 1.16e+00 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RSBN1L | SNV | Missense_Mutation | novel | c.829N>G | p.Gln277Glu | p.Q277E | Q6PCB5 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
RSBN1L | SNV | Missense_Mutation | rs765531692 | c.223N>T | p.Pro75Ser | p.P75S | Q6PCB5 | protein_coding | tolerated_low_confidence(0.14) | benign(0.037) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RSBN1L | SNV | Missense_Mutation | c.98C>T | p.Ser33Phe | p.S33F | Q6PCB5 | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
RSBN1L | SNV | Missense_Mutation | c.2093A>T | p.Asp698Val | p.D698V | Q6PCB5 | protein_coding | deleterious(0.03) | benign(0.067) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RSBN1L | SNV | Missense_Mutation | novel | c.49N>G | p.Thr17Ala | p.T17A | Q6PCB5 | protein_coding | tolerated_low_confidence(0.98) | benign(0) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RSBN1L | SNV | Missense_Mutation | rs762959199 | c.1102N>A | p.Glu368Lys | p.E368K | Q6PCB5 | protein_coding | deleterious(0.01) | probably_damaging(0.963) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RSBN1L | SNV | Missense_Mutation | c.2309N>G | p.Asn770Ser | p.N770S | Q6PCB5 | protein_coding | tolerated_low_confidence(0.2) | benign(0) | TCGA-AF-2687-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | xeloda | PD | |
RSBN1L | SNV | Missense_Mutation | c.690G>T | p.Lys230Asn | p.K230N | Q6PCB5 | protein_coding | tolerated(0.12) | benign(0.439) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RSBN1L | SNV | Missense_Mutation | c.1302G>T | p.Lys434Asn | p.K434N | Q6PCB5 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RSBN1L | SNV | Missense_Mutation | novel | c.751N>C | p.Lys251Gln | p.K251Q | Q6PCB5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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