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Gene: RNF20 |
Gene summary for RNF20 |
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Gene information | Species | Human | Gene symbol | RNF20 | Gene ID | 56254 |
Gene name | ring finger protein 20 | |
Gene Alias | BRE1 | |
Cytomap | 9q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q5VTR2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56254 | RNF20 | LZE2T | Human | Esophagus | ESCC | 3.18e-04 | 6.14e-01 | 0.082 |
56254 | RNF20 | LZE4T | Human | Esophagus | ESCC | 2.86e-15 | 4.02e-01 | 0.0811 |
56254 | RNF20 | LZE7T | Human | Esophagus | ESCC | 1.34e-08 | 3.29e-01 | 0.0667 |
56254 | RNF20 | LZE20T | Human | Esophagus | ESCC | 7.45e-04 | 1.26e-01 | 0.0662 |
56254 | RNF20 | LZE24T | Human | Esophagus | ESCC | 9.74e-14 | 3.16e-01 | 0.0596 |
56254 | RNF20 | LZE6T | Human | Esophagus | ESCC | 1.21e-04 | 2.43e-01 | 0.0845 |
56254 | RNF20 | P1T-E | Human | Esophagus | ESCC | 1.94e-07 | 3.26e-01 | 0.0875 |
56254 | RNF20 | P2T-E | Human | Esophagus | ESCC | 7.93e-32 | 5.46e-01 | 0.1177 |
56254 | RNF20 | P4T-E | Human | Esophagus | ESCC | 4.12e-10 | 2.77e-01 | 0.1323 |
56254 | RNF20 | P5T-E | Human | Esophagus | ESCC | 2.53e-04 | 1.30e-01 | 0.1327 |
56254 | RNF20 | P8T-E | Human | Esophagus | ESCC | 1.17e-12 | 1.75e-01 | 0.0889 |
56254 | RNF20 | P9T-E | Human | Esophagus | ESCC | 6.50e-09 | 2.14e-01 | 0.1131 |
56254 | RNF20 | P10T-E | Human | Esophagus | ESCC | 5.38e-14 | 2.63e-01 | 0.116 |
56254 | RNF20 | P11T-E | Human | Esophagus | ESCC | 3.05e-14 | 4.15e-01 | 0.1426 |
56254 | RNF20 | P12T-E | Human | Esophagus | ESCC | 7.78e-18 | 3.40e-01 | 0.1122 |
56254 | RNF20 | P15T-E | Human | Esophagus | ESCC | 1.76e-20 | 4.47e-01 | 0.1149 |
56254 | RNF20 | P16T-E | Human | Esophagus | ESCC | 1.71e-17 | 2.98e-01 | 0.1153 |
56254 | RNF20 | P17T-E | Human | Esophagus | ESCC | 1.51e-10 | 3.34e-01 | 0.1278 |
56254 | RNF20 | P20T-E | Human | Esophagus | ESCC | 1.85e-14 | 2.35e-01 | 0.1124 |
56254 | RNF20 | P21T-E | Human | Esophagus | ESCC | 6.95e-18 | 4.39e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:1903311110 | Esophagus | ESCC | regulation of mRNA metabolic process | 210/8552 | 288/18723 | 3.25e-21 | 5.56e-19 | 210 |
GO:1903320111 | Esophagus | ESCC | regulation of protein modification by small protein conjugation or removal | 181/8552 | 242/18723 | 1.80e-20 | 2.60e-18 | 181 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:0031396111 | Esophagus | ESCC | regulation of protein ubiquitination | 154/8552 | 210/18723 | 2.70e-16 | 2.04e-14 | 154 |
GO:0050684110 | Esophagus | ESCC | regulation of mRNA processing | 109/8552 | 137/18723 | 3.51e-16 | 2.59e-14 | 109 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:190332216 | Esophagus | ESCC | positive regulation of protein modification by small protein conjugation or removal | 99/8552 | 138/18723 | 4.39e-10 | 1.16e-08 | 99 |
GO:003105614 | Esophagus | ESCC | regulation of histone modification | 106/8552 | 152/18723 | 1.52e-09 | 3.55e-08 | 106 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00065136 | Esophagus | ESCC | protein monoubiquitination | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
GO:001657414 | Esophagus | ESCC | histone ubiquitination | 40/8552 | 47/18723 | 2.40e-08 | 4.55e-07 | 40 |
GO:003139816 | Esophagus | ESCC | positive regulation of protein ubiquitination | 82/8552 | 119/18723 | 2.41e-07 | 3.64e-06 | 82 |
GO:005068615 | Esophagus | ESCC | negative regulation of mRNA processing | 26/8552 | 29/18723 | 8.98e-07 | 1.15e-05 | 26 |
GO:000647914 | Esophagus | ESCC | protein methylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:000821314 | Esophagus | ESCC | protein alkylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:00310583 | Esophagus | ESCC | positive regulation of histone modification | 65/8552 | 92/18723 | 1.04e-06 | 1.31e-05 | 65 |
GO:003112412 | Esophagus | ESCC | mRNA 3'-end processing | 47/8552 | 62/18723 | 1.29e-06 | 1.58e-05 | 47 |
GO:003144013 | Esophagus | ESCC | regulation of mRNA 3'-end processing | 25/8552 | 28/18723 | 1.77e-06 | 2.10e-05 | 25 |
GO:00103904 | Esophagus | ESCC | histone monoubiquitination | 25/8552 | 29/18723 | 7.24e-06 | 7.20e-05 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF20 | SNV | Missense_Mutation | c.487N>A | p.Ala163Thr | p.A163T | Q5VTR2 | protein_coding | tolerated(0.06) | probably_damaging(0.977) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
RNF20 | SNV | Missense_Mutation | c.1360N>G | p.Met454Val | p.M454V | Q5VTR2 | protein_coding | deleterious(0.04) | possibly_damaging(0.761) | TCGA-CM-6677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RNF20 | SNV | Missense_Mutation | c.313N>T | p.Arg105Cys | p.R105C | Q5VTR2 | protein_coding | deleterious(0) | benign(0) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RNF20 | SNV | Missense_Mutation | rs761717076 | c.1048C>T | p.Arg350Trp | p.R350W | Q5VTR2 | protein_coding | deleterious(0) | possibly_damaging(0.756) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RNF20 | SNV | Missense_Mutation | rs776618752 | c.2642N>A | p.Arg881Gln | p.R881Q | Q5VTR2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RNF20 | SNV | Missense_Mutation | novel | c.1645N>A | p.Ala549Thr | p.A549T | Q5VTR2 | protein_coding | tolerated(0.28) | probably_damaging(0.984) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
RNF20 | SNV | Missense_Mutation | novel | c.2389N>A | p.Ala797Thr | p.A797T | Q5VTR2 | protein_coding | deleterious(0.03) | possibly_damaging(0.841) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
RNF20 | SNV | Missense_Mutation | novel | c.242N>A | p.Arg81Gln | p.R81Q | Q5VTR2 | protein_coding | deleterious(0.03) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RNF20 | SNV | Missense_Mutation | rs765010969 | c.284N>A | p.Arg95Gln | p.R95Q | Q5VTR2 | protein_coding | deleterious(0.04) | benign(0.122) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF20 | SNV | Missense_Mutation | novel | c.1041N>T | p.Glu347Asp | p.E347D | Q5VTR2 | protein_coding | tolerated(0.39) | benign(0.162) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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