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Gene: RNF123 |
Gene summary for RNF123 |
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Gene information | Species | Human | Gene symbol | RNF123 | Gene ID | 63891 |
Gene name | ring finger protein 123 | |
Gene Alias | FP1477 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q5XPI4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63891 | RNF123 | HCC1_Meng | Human | Liver | HCC | 6.11e-34 | 2.84e-02 | 0.0246 |
63891 | RNF123 | HCC2 | Human | Liver | HCC | 6.64e-05 | 2.56e+00 | 0.5341 |
63891 | RNF123 | S015 | Human | Liver | HCC | 2.53e-05 | 4.24e-01 | 0.2375 |
63891 | RNF123 | S028 | Human | Liver | HCC | 2.86e-11 | 5.55e-01 | 0.2503 |
63891 | RNF123 | S029 | Human | Liver | HCC | 9.83e-08 | 5.48e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF123 | SNV | Missense_Mutation | c.1912N>G | p.Met638Val | p.M638V | Q5XPI4 | protein_coding | tolerated(0.2) | possibly_damaging(0.761) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
RNF123 | SNV | Missense_Mutation | novel | c.544N>G | p.Asn182Asp | p.N182D | Q5XPI4 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RNF123 | SNV | Missense_Mutation | rs369371695 | c.1216N>T | p.Arg406Trp | p.R406W | Q5XPI4 | protein_coding | tolerated(0.12) | possibly_damaging(0.513) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RNF123 | SNV | Missense_Mutation | novel | c.3464N>C | p.Ile1155Thr | p.I1155T | Q5XPI4 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RNF123 | SNV | Missense_Mutation | novel | c.3889N>C | p.Ser1297Pro | p.S1297P | Q5XPI4 | protein_coding | tolerated(0.13) | benign(0.214) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RNF123 | SNV | Missense_Mutation | rs150915433 | c.2840N>A | p.Arg947His | p.R947H | Q5XPI4 | protein_coding | deleterious(0.01) | possibly_damaging(0.563) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
RNF123 | SNV | Missense_Mutation | c.1627G>A | p.Gly543Arg | p.G543R | Q5XPI4 | protein_coding | tolerated(0.15) | probably_damaging(0.999) | TCGA-CM-5868-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
RNF123 | SNV | Missense_Mutation | rs754168663 | c.3626N>A | p.Arg1209His | p.R1209H | Q5XPI4 | protein_coding | tolerated(0.34) | benign(0) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
RNF123 | SNV | Missense_Mutation | rs762516169 | c.3619C>T | p.Arg1207Trp | p.R1207W | Q5XPI4 | protein_coding | deleterious(0.02) | benign(0.249) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF123 | SNV | Missense_Mutation | c.3241C>A | p.Leu1081Met | p.L1081M | Q5XPI4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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