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Gene: RHBG |
Gene summary for RHBG |
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Gene information | Species | Human | Gene symbol | RHBG | Gene ID | 57127 |
Gene name | Rh family B glycoprotein | |
Gene Alias | SLC42A2 | |
Cytomap | 1q22 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9H310 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57127 | RHBG | HCC1 | Human | Liver | HCC | 5.67e-25 | 4.73e+00 | 0.5336 |
57127 | RHBG | HCC2 | Human | Liver | HCC | 1.55e-07 | 2.78e+00 | 0.5341 |
57127 | RHBG | HCC5 | Human | Liver | HCC | 5.27e-03 | 2.42e+00 | 0.4932 |
57127 | RHBG | S014 | Human | Liver | HCC | 2.30e-23 | 7.61e-01 | 0.2254 |
57127 | RHBG | S015 | Human | Liver | HCC | 4.27e-24 | 8.10e-01 | 0.2375 |
57127 | RHBG | S016 | Human | Liver | HCC | 1.43e-35 | 9.30e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RHBG | SNV | Missense_Mutation | novel | c.805N>C | p.Ser269Pro | p.S269P | Q9H310 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
RHBG | SNV | Missense_Mutation | novel | c.337N>A | p.Ser113Thr | p.S113T | Q9H310 | protein_coding | tolerated(0.23) | benign(0.009) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RHBG | SNV | Missense_Mutation | novel | c.972N>A | p.Phe324Leu | p.F324L | Q9H310 | protein_coding | deleterious(0.03) | possibly_damaging(0.482) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
RHBG | SNV | Missense_Mutation | novel | c.925N>A | p.Ala309Thr | p.A309T | Q9H310 | protein_coding | deleterious(0.05) | benign(0.069) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
RHBG | SNV | Missense_Mutation | novel | c.404C>G | p.Ala135Gly | p.A135G | Q9H310 | protein_coding | tolerated(0.19) | possibly_damaging(0.61) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
RHBG | SNV | Missense_Mutation | rs753409271 | c.23C>T | p.Ala8Val | p.A8V | Q9H310 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RHBG | SNV | Missense_Mutation | novel | c.936N>A | p.Phe312Leu | p.F312L | Q9H310 | protein_coding | tolerated(0.18) | possibly_damaging(0.61) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RHBG | SNV | Missense_Mutation | novel | c.193C>A | p.Gln65Lys | p.Q65K | Q9H310 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
RHBG | SNV | Missense_Mutation | rs755542961 | c.664G>A | p.Ala222Thr | p.A222T | Q9H310 | protein_coding | deleterious(0.01) | possibly_damaging(0.881) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RHBG | SNV | Missense_Mutation | rs774146663 | c.1151G>A | p.Arg384His | p.R384H | Q9H310 | protein_coding | tolerated(0.09) | probably_damaging(1) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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