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Gene: REST |
Gene summary for REST |
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Gene information | Species | Human | Gene symbol | REST | Gene ID | 5978 |
Gene name | RE1 silencing transcription factor | |
Gene Alias | DFNA27 | |
Cytomap | 4q12 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q13127 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5978 | REST | LZE2T | Human | Esophagus | ESCC | 1.52e-02 | 5.83e-01 | 0.082 |
5978 | REST | LZE4T | Human | Esophagus | ESCC | 5.92e-15 | 4.81e-01 | 0.0811 |
5978 | REST | LZE5T | Human | Esophagus | ESCC | 5.23e-03 | 2.24e-01 | 0.0514 |
5978 | REST | LZE7T | Human | Esophagus | ESCC | 2.65e-04 | 3.94e-01 | 0.0667 |
5978 | REST | LZE8T | Human | Esophagus | ESCC | 8.02e-06 | 1.11e-01 | 0.067 |
5978 | REST | LZE20T | Human | Esophagus | ESCC | 7.39e-08 | 2.78e-01 | 0.0662 |
5978 | REST | LZE21D1 | Human | Esophagus | HGIN | 4.54e-02 | 1.16e-01 | 0.0632 |
5978 | REST | LZE22T | Human | Esophagus | ESCC | 5.18e-04 | 4.03e-01 | 0.068 |
5978 | REST | LZE24T | Human | Esophagus | ESCC | 6.48e-25 | 7.52e-01 | 0.0596 |
5978 | REST | LZE21T | Human | Esophagus | ESCC | 3.53e-08 | 4.36e-01 | 0.0655 |
5978 | REST | P1T-E | Human | Esophagus | ESCC | 9.93e-14 | 7.14e-01 | 0.0875 |
5978 | REST | P2T-E | Human | Esophagus | ESCC | 5.17e-82 | 1.40e+00 | 0.1177 |
5978 | REST | P4T-E | Human | Esophagus | ESCC | 1.20e-43 | 9.93e-01 | 0.1323 |
5978 | REST | P5T-E | Human | Esophagus | ESCC | 1.10e-21 | 4.16e-01 | 0.1327 |
5978 | REST | P8T-E | Human | Esophagus | ESCC | 3.71e-50 | 1.01e+00 | 0.0889 |
5978 | REST | P9T-E | Human | Esophagus | ESCC | 5.27e-16 | 3.83e-01 | 0.1131 |
5978 | REST | P10T-E | Human | Esophagus | ESCC | 4.10e-50 | 8.64e-01 | 0.116 |
5978 | REST | P11T-E | Human | Esophagus | ESCC | 2.58e-14 | 6.56e-01 | 0.1426 |
5978 | REST | P12T-E | Human | Esophagus | ESCC | 1.08e-47 | 1.09e+00 | 0.1122 |
5978 | REST | P15T-E | Human | Esophagus | ESCC | 1.98e-46 | 9.90e-01 | 0.1149 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:000037520 | Esophagus | HGIN | RNA splicing, via transesterification reactions | 115/2587 | 324/18723 | 3.16e-23 | 3.80e-20 | 115 |
GO:000037720 | Esophagus | HGIN | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:000039820 | Esophagus | HGIN | mRNA splicing, via spliceosome | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:001603227 | Esophagus | HGIN | viral process | 118/2587 | 415/18723 | 3.01e-15 | 6.22e-13 | 118 |
GO:004348427 | Esophagus | HGIN | regulation of RNA splicing | 59/2587 | 148/18723 | 3.61e-15 | 7.22e-13 | 59 |
GO:190331120 | Esophagus | HGIN | regulation of mRNA metabolic process | 91/2587 | 288/18723 | 5.06e-15 | 9.78e-13 | 91 |
GO:005068419 | Esophagus | HGIN | regulation of mRNA processing | 55/2587 | 137/18723 | 2.17e-14 | 3.94e-12 | 55 |
GO:004586227 | Esophagus | HGIN | positive regulation of proteolysis | 107/2587 | 372/18723 | 2.61e-14 | 4.60e-12 | 107 |
GO:004802426 | Esophagus | HGIN | regulation of mRNA splicing, via spliceosome | 42/2587 | 101/18723 | 6.35e-12 | 7.78e-10 | 42 |
GO:000038018 | Esophagus | HGIN | alternative mRNA splicing, via spliceosome | 32/2587 | 77/18723 | 2.06e-09 | 1.54e-07 | 32 |
GO:000697927 | Esophagus | HGIN | response to oxidative stress | 107/2587 | 446/18723 | 3.91e-09 | 2.76e-07 | 107 |
GO:004328126 | Esophagus | HGIN | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 59/2587 | 209/18723 | 3.39e-08 | 1.97e-06 | 59 |
GO:200011626 | Esophagus | HGIN | regulation of cysteine-type endopeptidase activity | 63/2587 | 235/18723 | 9.71e-08 | 5.02e-06 | 63 |
GO:005254726 | Esophagus | HGIN | regulation of peptidase activity | 102/2587 | 461/18723 | 6.29e-07 | 2.72e-05 | 102 |
GO:004440326 | Esophagus | HGIN | biological process involved in symbiotic interaction | 71/2587 | 290/18723 | 7.09e-07 | 3.00e-05 | 71 |
GO:001095225 | Esophagus | HGIN | positive regulation of peptidase activity | 53/2587 | 197/18723 | 8.70e-07 | 3.59e-05 | 53 |
GO:005254826 | Esophagus | HGIN | regulation of endopeptidase activity | 96/2587 | 432/18723 | 1.09e-06 | 4.30e-05 | 96 |
GO:00198277 | Esophagus | HGIN | stem cell population maintenance | 39/2587 | 131/18723 | 1.63e-06 | 6.14e-05 | 39 |
GO:004328020 | Esophagus | HGIN | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 38/2587 | 129/18723 | 2.92e-06 | 1.01e-04 | 38 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501630 | Esophagus | HGIN | Huntington disease | 129/1383 | 306/8465 | 6.81e-28 | 7.41e-26 | 5.88e-26 | 129 |
hsa05016113 | Esophagus | HGIN | Huntington disease | 129/1383 | 306/8465 | 6.81e-28 | 7.41e-26 | 5.88e-26 | 129 |
hsa05016210 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa0501638 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa0501614 | Liver | Cirrhotic | Huntington disease | 172/2530 | 306/8465 | 1.65e-22 | 1.10e-20 | 6.77e-21 | 172 |
hsa0501615 | Liver | Cirrhotic | Huntington disease | 172/2530 | 306/8465 | 1.65e-22 | 1.10e-20 | 6.77e-21 | 172 |
hsa0501622 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa0501632 | Liver | HCC | Huntington disease | 219/4020 | 306/8465 | 3.06e-18 | 3.42e-16 | 1.90e-16 | 219 |
hsa0501628 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa05016112 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa0501626 | Prostate | BPH | Huntington disease | 149/1718 | 306/8465 | 8.82e-30 | 7.27e-28 | 4.50e-28 | 149 |
hsa05016111 | Prostate | BPH | Huntington disease | 149/1718 | 306/8465 | 8.82e-30 | 7.27e-28 | 4.50e-28 | 149 |
hsa0501627 | Prostate | Tumor | Huntington disease | 150/1791 | 306/8465 | 2.72e-28 | 2.25e-26 | 1.40e-26 | 150 |
hsa0501636 | Prostate | Tumor | Huntington disease | 150/1791 | 306/8465 | 2.72e-28 | 2.25e-26 | 1.40e-26 | 150 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
REST | MAIT | Colorectum | SER | MTHFR,PSD3,SPECC1, etc. | 2.66e-02 | ![]() |
REST | STM | Oral cavity | LP | GABRP,FAM111B,RP11-983G14.1, etc. | 5.24e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
REST | SNV | Missense_Mutation | novel | c.568N>A | p.Glu190Lys | p.E190K | Q13127 | protein_coding | tolerated(0.07) | probably_damaging(0.993) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
REST | SNV | Missense_Mutation | novel | c.464N>G | p.Lys155Arg | p.K155R | Q13127 | protein_coding | deleterious(0.03) | benign(0.18) | TCGA-AA-A02W-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
REST | SNV | Missense_Mutation | novel | c.3010N>A | p.Glu1004Lys | p.E1004K | Q13127 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-AA-A03J-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
REST | SNV | Missense_Mutation | c.2708N>C | p.Asp903Ala | p.D903A | Q13127 | protein_coding | tolerated(0.07) | benign(0.024) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
REST | SNV | Missense_Mutation | rs867829350 | c.2695N>A | p.Ala899Thr | p.A899T | Q13127 | protein_coding | tolerated(0.31) | benign(0.003) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
REST | SNV | Missense_Mutation | novel | c.745N>G | p.Lys249Glu | p.K249E | Q13127 | protein_coding | deleterious(0) | possibly_damaging(0.888) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
REST | SNV | Missense_Mutation | c.1948N>A | p.Glu650Lys | p.E650K | Q13127 | protein_coding | tolerated(0.53) | benign(0) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
REST | SNV | Missense_Mutation | c.552N>T | p.Lys184Asn | p.K184N | Q13127 | protein_coding | tolerated(0.05) | benign(0.288) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
REST | SNV | Missense_Mutation | c.127N>A | p.Ala43Thr | p.A43T | Q13127 | protein_coding | deleterious(0.05) | probably_damaging(0.964) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
REST | SNV | Missense_Mutation | c.2195N>T | p.Glu732Val | p.E732V | Q13127 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.483) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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