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Gene: RDH16 |
Gene summary for RDH16 |
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Gene information | Species | Human | Gene symbol | RDH16 | Gene ID | 8608 |
Gene name | retinol dehydrogenase 16 | |
Gene Alias | RODH-4 | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0001523 | UniProtAcc | Q59FX7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8608 | RDH16 | C04 | Human | Oral cavity | OSCC | 3.41e-02 | 1.50e-01 | 0.2633 |
8608 | RDH16 | C21 | Human | Oral cavity | OSCC | 2.04e-04 | 1.97e-01 | 0.2678 |
8608 | RDH16 | C30 | Human | Oral cavity | OSCC | 5.33e-08 | 3.79e-01 | 0.3055 |
8608 | RDH16 | C38 | Human | Oral cavity | OSCC | 3.61e-03 | 3.84e-01 | 0.172 |
8608 | RDH16 | C43 | Human | Oral cavity | OSCC | 5.27e-33 | 5.59e-01 | 0.1704 |
8608 | RDH16 | C46 | Human | Oral cavity | OSCC | 1.64e-03 | 1.36e-01 | 0.1673 |
8608 | RDH16 | C51 | Human | Oral cavity | OSCC | 8.80e-22 | 9.01e-01 | 0.2674 |
8608 | RDH16 | C06 | Human | Oral cavity | OSCC | 2.90e-05 | 5.35e-01 | 0.2699 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002290018 | Oral cavity | OSCC | electron transport chain | 126/7305 | 175/18723 | 6.65e-19 | 8.42e-17 | 126 |
GO:000609118 | Oral cavity | OSCC | generation of precursor metabolites and energy | 286/7305 | 490/18723 | 1.45e-18 | 1.71e-16 | 286 |
GO:00060667 | Oral cavity | OSCC | alcohol metabolic process | 179/7305 | 353/18723 | 4.54e-06 | 5.21e-05 | 179 |
GO:00067203 | Oral cavity | OSCC | isoprenoid metabolic process | 59/7305 | 116/18723 | 6.18e-03 | 2.33e-02 | 59 |
GO:00082024 | Oral cavity | OSCC | steroid metabolic process | 146/7305 | 319/18723 | 7.78e-03 | 2.85e-02 | 146 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RDH16 | SNV | Missense_Mutation | novel | c.355N>G | p.Thr119Ala | p.T119A | O75452 | protein_coding | tolerated(0.52) | benign(0.006) | TCGA-DD-AADP-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RDH16 | SNV | Missense_Mutation | c.940N>T | p.Ala314Ser | p.A314S | O75452 | protein_coding | tolerated(0.08) | benign(0.142) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
RDH16 | SNV | Missense_Mutation | c.433N>T | p.Thr145Ser | p.T145S | O75452 | protein_coding | deleterious(0.02) | probably_damaging(0.951) | TCGA-18-3421-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RDH16 | SNV | Missense_Mutation | novel | c.686N>T | p.Arg229Leu | p.R229L | O75452 | protein_coding | deleterious(0.02) | benign(0.044) | TCGA-37-4132-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RDH16 | SNV | Missense_Mutation | novel | c.427G>T | p.Asp143Tyr | p.D143Y | O75452 | protein_coding | deleterious(0) | possibly_damaging(0.906) | TCGA-85-A4JC-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | unknown | PD |
RDH16 | SNV | Missense_Mutation | novel | c.305N>C | p.Arg102Thr | p.R102T | O75452 | protein_coding | deleterious(0) | benign(0.003) | TCGA-94-A5I4-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RDH16 | SNV | Missense_Mutation | novel | c.427G>A | p.Asp143Asn | p.D143N | O75452 | protein_coding | deleterious(0.05) | benign(0.084) | TCGA-BR-8060-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RDH16 | SNV | Missense_Mutation | rs201496901 | c.503N>A | p.Arg168Gln | p.R168Q | O75452 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-D7-8573-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RDH16 | SNV | Missense_Mutation | c.97T>C | p.Phe33Leu | p.F33L | O75452 | protein_coding | tolerated(0.26) | benign(0.035) | TCGA-FP-7916-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
RDH16 | SNV | Missense_Mutation | c.722N>C | p.Lys241Thr | p.K241T | O75452 | protein_coding | tolerated(0.2) | benign(0.006) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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