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Gene: RCN3 |
Gene summary for RCN3 |
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Gene information | Species | Human | Gene symbol | RCN3 | Gene ID | 57333 |
Gene name | reticulocalbin 3 | |
Gene Alias | RLP49 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | Q96D15 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57333 | RCN3 | LZE22T | Human | Esophagus | ESCC | 5.50e-06 | 4.43e-01 | 0.068 |
57333 | RCN3 | P2T-E | Human | Esophagus | ESCC | 6.02e-05 | 3.15e-02 | 0.1177 |
57333 | RCN3 | P4T-E | Human | Esophagus | ESCC | 6.44e-14 | 7.89e-01 | 0.1323 |
57333 | RCN3 | P5T-E | Human | Esophagus | ESCC | 7.10e-05 | 4.40e-01 | 0.1327 |
57333 | RCN3 | P8T-E | Human | Esophagus | ESCC | 9.19e-18 | 3.90e-01 | 0.0889 |
57333 | RCN3 | P9T-E | Human | Esophagus | ESCC | 9.99e-10 | 6.75e-01 | 0.1131 |
57333 | RCN3 | P11T-E | Human | Esophagus | ESCC | 3.03e-28 | 8.24e-01 | 0.1426 |
57333 | RCN3 | P12T-E | Human | Esophagus | ESCC | 6.40e-34 | 6.17e-01 | 0.1122 |
57333 | RCN3 | P15T-E | Human | Esophagus | ESCC | 4.47e-02 | 3.44e-01 | 0.1149 |
57333 | RCN3 | P17T-E | Human | Esophagus | ESCC | 1.29e-03 | 2.92e-01 | 0.1278 |
57333 | RCN3 | P19T-E | Human | Esophagus | ESCC | 8.13e-13 | 1.14e+00 | 0.1662 |
57333 | RCN3 | P22T-E | Human | Esophagus | ESCC | 4.20e-04 | 3.92e-01 | 0.1236 |
57333 | RCN3 | P23T-E | Human | Esophagus | ESCC | 5.99e-13 | 4.63e-01 | 0.108 |
57333 | RCN3 | P24T-E | Human | Esophagus | ESCC | 2.05e-04 | 3.56e-01 | 0.1287 |
57333 | RCN3 | P26T-E | Human | Esophagus | ESCC | 1.67e-27 | 5.11e-01 | 0.1276 |
57333 | RCN3 | P27T-E | Human | Esophagus | ESCC | 1.29e-06 | 1.64e-01 | 0.1055 |
57333 | RCN3 | P32T-E | Human | Esophagus | ESCC | 2.05e-24 | 7.05e-01 | 0.1666 |
57333 | RCN3 | P37T-E | Human | Esophagus | ESCC | 1.54e-24 | 7.57e-01 | 0.1371 |
57333 | RCN3 | P38T-E | Human | Esophagus | ESCC | 2.33e-05 | 1.53e-01 | 0.127 |
57333 | RCN3 | P42T-E | Human | Esophagus | ESCC | 1.18e-09 | 5.78e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0034976111 | Esophagus | ESCC | response to endoplasmic reticulum stress | 192/8552 | 256/18723 | 7.15e-22 | 1.30e-19 | 192 |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
GO:003650315 | Esophagus | ESCC | ERAD pathway | 82/8552 | 107/18723 | 5.80e-11 | 1.84e-09 | 82 |
GO:0010952111 | Esophagus | ESCC | positive regulation of peptidase activity | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:0052547111 | Esophagus | ESCC | regulation of peptidase activity | 275/8552 | 461/18723 | 7.54e-10 | 1.88e-08 | 275 |
GO:00303239 | Esophagus | ESCC | respiratory tube development | 112/8552 | 181/18723 | 7.82e-06 | 7.69e-05 | 112 |
GO:00605417 | Esophagus | ESCC | respiratory system development | 123/8552 | 203/18723 | 1.26e-05 | 1.15e-04 | 123 |
GO:00303249 | Esophagus | ESCC | lung development | 109/8552 | 177/18723 | 1.40e-05 | 1.27e-04 | 109 |
GO:00604284 | Esophagus | ESCC | lung epithelium development | 27/8552 | 37/18723 | 7.00e-04 | 3.66e-03 | 27 |
GO:00329631 | Esophagus | ESCC | collagen metabolic process | 62/8552 | 104/18723 | 2.90e-03 | 1.22e-02 | 62 |
GO:000930617 | Esophagus | ESCC | protein secretion | 190/8552 | 359/18723 | 3.22e-03 | 1.34e-02 | 190 |
GO:003559217 | Esophagus | ESCC | establishment of protein localization to extracellular region | 190/8552 | 360/18723 | 3.77e-03 | 1.53e-02 | 190 |
GO:007169210 | Esophagus | ESCC | protein localization to extracellular region | 193/8552 | 368/18723 | 5.01e-03 | 1.92e-02 | 193 |
GO:001049820 | Oral cavity | OSCC | proteasomal protein catabolic process | 336/7305 | 490/18723 | 5.45e-41 | 8.63e-38 | 336 |
GO:003497620 | Oral cavity | OSCC | response to endoplasmic reticulum stress | 178/7305 | 256/18723 | 2.59e-23 | 6.06e-21 | 178 |
GO:004586220 | Oral cavity | OSCC | positive regulation of proteolysis | 236/7305 | 372/18723 | 6.53e-22 | 1.38e-19 | 236 |
GO:005254720 | Oral cavity | OSCC | regulation of peptidase activity | 255/7305 | 461/18723 | 5.78e-13 | 2.75e-11 | 255 |
GO:00365035 | Oral cavity | OSCC | ERAD pathway | 76/7305 | 107/18723 | 1.76e-11 | 6.11e-10 | 76 |
GO:001095220 | Oral cavity | OSCC | positive regulation of peptidase activity | 123/7305 | 197/18723 | 2.12e-11 | 7.21e-10 | 123 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RCN3 | SNV | Missense_Mutation | c.138T>A | p.Asp46Glu | p.D46E | Q96D15 | protein_coding | tolerated(0.42) | benign(0.034) | TCGA-55-A48Y-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
RCN3 | SNV | Missense_Mutation | rs774822949 | c.601C>T | p.Arg201Trp | p.R201W | Q96D15 | protein_coding | deleterious(0) | possibly_damaging(0.523) | TCGA-69-7973-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
RCN3 | SNV | Missense_Mutation | novel | c.141C>A | p.Asp47Glu | p.D47E | Q96D15 | protein_coding | tolerated(0.14) | possibly_damaging(0.823) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RCN3 | SNV | Missense_Mutation | c.127N>T | p.Ala43Ser | p.A43S | Q96D15 | protein_coding | tolerated(0.7) | benign(0.145) | TCGA-MP-A4SY-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
RCN3 | SNV | Missense_Mutation | c.466N>C | p.Glu156Gln | p.E156Q | Q96D15 | protein_coding | tolerated(0.12) | benign(0.095) | TCGA-18-3419-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RCN3 | SNV | Missense_Mutation | novel | c.100G>T | p.Val34Leu | p.V34L | Q96D15 | protein_coding | deleterious(0.02) | benign(0.249) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RCN3 | SNV | Missense_Mutation | novel | c.133N>A | p.His45Asn | p.H45N | Q96D15 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
RCN3 | SNV | Missense_Mutation | novel | c.110C>T | p.Ala37Val | p.A37V | Q96D15 | protein_coding | tolerated(0.28) | benign(0.009) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
RCN3 | SNV | Missense_Mutation | c.163N>A | p.Asp55Asn | p.D55N | Q96D15 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RCN3 | SNV | Missense_Mutation | c.674N>T | p.Tyr225Phe | p.Y225F | Q96D15 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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