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Gene: RCE1 |
Gene summary for RCE1 |
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Gene information | Species | Human | Gene symbol | RCE1 | Gene ID | 9986 |
Gene name | Ras converting CAAX endopeptidase 1 | |
Gene Alias | FACE2 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | A0A024R5B6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9986 | RCE1 | LZE4T | Human | Esophagus | ESCC | 4.88e-03 | 1.31e-01 | 0.0811 |
9986 | RCE1 | LZE7T | Human | Esophagus | ESCC | 2.65e-03 | 1.95e-01 | 0.0667 |
9986 | RCE1 | LZE20T | Human | Esophagus | ESCC | 3.70e-12 | 7.00e-01 | 0.0662 |
9986 | RCE1 | LZE22T | Human | Esophagus | ESCC | 3.40e-03 | 4.19e-01 | 0.068 |
9986 | RCE1 | LZE24T | Human | Esophagus | ESCC | 1.06e-29 | 8.22e-01 | 0.0596 |
9986 | RCE1 | P1T-E | Human | Esophagus | ESCC | 7.86e-07 | 4.08e-01 | 0.0875 |
9986 | RCE1 | P2T-E | Human | Esophagus | ESCC | 3.74e-23 | 4.72e-01 | 0.1177 |
9986 | RCE1 | P4T-E | Human | Esophagus | ESCC | 2.82e-28 | 7.27e-01 | 0.1323 |
9986 | RCE1 | P5T-E | Human | Esophagus | ESCC | 1.59e-45 | 8.87e-01 | 0.1327 |
9986 | RCE1 | P8T-E | Human | Esophagus | ESCC | 3.33e-44 | 7.51e-01 | 0.0889 |
9986 | RCE1 | P9T-E | Human | Esophagus | ESCC | 5.47e-11 | 3.13e-01 | 0.1131 |
9986 | RCE1 | P10T-E | Human | Esophagus | ESCC | 5.03e-21 | 3.18e-01 | 0.116 |
9986 | RCE1 | P11T-E | Human | Esophagus | ESCC | 4.91e-22 | 9.29e-01 | 0.1426 |
9986 | RCE1 | P12T-E | Human | Esophagus | ESCC | 1.19e-24 | 5.15e-01 | 0.1122 |
9986 | RCE1 | P15T-E | Human | Esophagus | ESCC | 5.14e-30 | 6.96e-01 | 0.1149 |
9986 | RCE1 | P16T-E | Human | Esophagus | ESCC | 4.24e-43 | 6.50e-01 | 0.1153 |
9986 | RCE1 | P17T-E | Human | Esophagus | ESCC | 4.95e-11 | 4.63e-01 | 0.1278 |
9986 | RCE1 | P19T-E | Human | Esophagus | ESCC | 1.29e-05 | 5.01e-01 | 0.1662 |
9986 | RCE1 | P20T-E | Human | Esophagus | ESCC | 1.60e-34 | 8.53e-01 | 0.1124 |
9986 | RCE1 | P21T-E | Human | Esophagus | ESCC | 6.17e-45 | 9.01e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00224119 | Breast | Precancer | cellular component disassembly | 44/1080 | 443/18723 | 3.17e-04 | 4.51e-03 | 44 |
GO:00329865 | Breast | Precancer | protein-DNA complex disassembly | 6/1080 | 20/18723 | 6.99e-04 | 8.43e-03 | 6 |
GO:003298612 | Breast | IDC | protein-DNA complex disassembly | 6/1434 | 20/18723 | 3.03e-03 | 2.60e-02 | 6 |
GO:003298621 | Breast | DCIS | protein-DNA complex disassembly | 6/1390 | 20/18723 | 2.59e-03 | 2.30e-02 | 6 |
GO:002241113 | Breast | DCIS | cellular component disassembly | 48/1390 | 443/18723 | 5.35e-03 | 3.92e-02 | 48 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0032986 | Colorectum | AD | protein-DNA complex disassembly | 12/3918 | 20/18723 | 1.60e-04 | 2.21e-03 | 12 |
GO:0031498 | Colorectum | AD | chromatin disassembly | 11/3918 | 20/18723 | 8.39e-04 | 8.21e-03 | 11 |
GO:0006337 | Colorectum | AD | nucleosome disassembly | 10/3918 | 18/18723 | 1.31e-03 | 1.15e-02 | 10 |
GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
GO:00329841 | Colorectum | SER | protein-containing complex disassembly | 61/2897 | 224/18723 | 4.17e-06 | 1.60e-04 | 61 |
GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
GO:00314981 | Colorectum | SER | chromatin disassembly | 8/2897 | 20/18723 | 7.14e-03 | 4.99e-02 | 8 |
GO:00329861 | Colorectum | SER | protein-DNA complex disassembly | 8/2897 | 20/18723 | 7.14e-03 | 4.99e-02 | 8 |
GO:00224112 | Colorectum | MSS | cellular component disassembly | 130/3467 | 443/18723 | 1.44e-08 | 8.46e-07 | 130 |
GO:00329842 | Colorectum | MSS | protein-containing complex disassembly | 69/3467 | 224/18723 | 5.61e-06 | 1.50e-04 | 69 |
GO:00329862 | Colorectum | MSS | protein-DNA complex disassembly | 12/3467 | 20/18723 | 4.55e-05 | 8.35e-04 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa009005 | Esophagus | ESCC | Terpenoid backbone biosynthesis | 20/4205 | 23/8465 | 2.14e-04 | 7.87e-04 | 4.03e-04 | 20 |
hsa0090012 | Esophagus | ESCC | Terpenoid backbone biosynthesis | 20/4205 | 23/8465 | 2.14e-04 | 7.87e-04 | 4.03e-04 | 20 |
hsa00900 | Liver | HCC | Terpenoid backbone biosynthesis | 17/4020 | 23/8465 | 9.26e-03 | 2.46e-02 | 1.37e-02 | 17 |
hsa009001 | Liver | HCC | Terpenoid backbone biosynthesis | 17/4020 | 23/8465 | 9.26e-03 | 2.46e-02 | 1.37e-02 | 17 |
hsa009004 | Oral cavity | OSCC | Terpenoid backbone biosynthesis | 19/3704 | 23/8465 | 1.55e-04 | 5.34e-04 | 2.72e-04 | 19 |
hsa0090011 | Oral cavity | OSCC | Terpenoid backbone biosynthesis | 19/3704 | 23/8465 | 1.55e-04 | 5.34e-04 | 2.72e-04 | 19 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RCE1 | SNV | Missense_Mutation | rs750535440 | c.404N>T | p.Ser135Phe | p.S135F | Q9Y256 | protein_coding | tolerated(0.15) | benign(0.265) | TCGA-46-6026-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
RCE1 | SNV | Missense_Mutation | novel | c.389N>A | p.Pro130Gln | p.P130Q | Q9Y256 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
RCE1 | SNV | Missense_Mutation | c.511N>A | p.Ala171Thr | p.A171T | Q9Y256 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-CV-5443-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
RCE1 | SNV | Missense_Mutation | novel | c.515C>T | p.Pro172Leu | p.P172L | Q9Y256 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CV-7437-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RCE1 | SNV | Missense_Mutation | rs758150912 | c.925N>A | p.Gly309Ser | p.G309S | Q9Y256 | protein_coding | tolerated(0.33) | benign(0.006) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RCE1 | SNV | Missense_Mutation | rs746725023 | c.844C>T | p.Arg282Trp | p.R282W | Q9Y256 | protein_coding | tolerated(0.19) | benign(0) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
RCE1 | SNV | Missense_Mutation | c.803N>T | p.Gly268Val | p.G268V | Q9Y256 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RCE1 | SNV | Missense_Mutation | novel | c.795N>A | p.Asn265Lys | p.N265K | Q9Y256 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | NSC-37136 | CHEMBL1370674 | ||
9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | inhibitor | 252166757 | ||
9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | FLUNARIZINE DIHYDROCHLORIDE | FLUNARIZINE DIHYDROCHLORIDE | ||
9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | HTS-9915 | CHEMBL512935 | ||
9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | SJ000293754 | CHEMBL486706 | ||
9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | LEVOFLOXACIN | LEVOFLOXACIN | ||
9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | inhibitor | 252166780 | ||
9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | ACRIDIN-1-YLAMINE | CHEMBL146525 | ||
9986 | RCE1 | ENZYME, PROTEASE, DRUGGABLE GENOME | GNF-PF-763 | CHEMBL1576338 |
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