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Gene: RCC1 |
Gene summary for RCC1 |
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Gene information | Species | Human | Gene symbol | RCC1 | Gene ID | 1104 |
Gene name | regulator of chromosome condensation 1 | |
Gene Alias | CHC1 | |
Cytomap | 1p35.3 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | A0A0S2Z404 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1104 | RCC1 | LZE4T | Human | Esophagus | ESCC | 5.76e-04 | 7.72e-02 | 0.0811 |
1104 | RCC1 | LZE8T | Human | Esophagus | ESCC | 6.08e-04 | 1.90e-01 | 0.067 |
1104 | RCC1 | LZE20T | Human | Esophagus | ESCC | 1.40e-02 | 1.44e-01 | 0.0662 |
1104 | RCC1 | LZE22T | Human | Esophagus | ESCC | 4.75e-06 | 6.62e-01 | 0.068 |
1104 | RCC1 | LZE24T | Human | Esophagus | ESCC | 1.83e-09 | 3.92e-01 | 0.0596 |
1104 | RCC1 | LZE6T | Human | Esophagus | ESCC | 1.28e-02 | 2.94e-01 | 0.0845 |
1104 | RCC1 | P1T-E | Human | Esophagus | ESCC | 1.12e-13 | 7.63e-01 | 0.0875 |
1104 | RCC1 | P2T-E | Human | Esophagus | ESCC | 1.18e-41 | 1.05e+00 | 0.1177 |
1104 | RCC1 | P4T-E | Human | Esophagus | ESCC | 1.32e-40 | 1.10e+00 | 0.1323 |
1104 | RCC1 | P5T-E | Human | Esophagus | ESCC | 4.84e-37 | 8.63e-01 | 0.1327 |
1104 | RCC1 | P8T-E | Human | Esophagus | ESCC | 8.89e-41 | 9.26e-01 | 0.0889 |
1104 | RCC1 | P9T-E | Human | Esophagus | ESCC | 1.81e-31 | 8.80e-01 | 0.1131 |
1104 | RCC1 | P10T-E | Human | Esophagus | ESCC | 3.16e-62 | 1.23e+00 | 0.116 |
1104 | RCC1 | P11T-E | Human | Esophagus | ESCC | 2.47e-13 | 7.90e-01 | 0.1426 |
1104 | RCC1 | P12T-E | Human | Esophagus | ESCC | 9.73e-37 | 8.13e-01 | 0.1122 |
1104 | RCC1 | P15T-E | Human | Esophagus | ESCC | 1.10e-32 | 7.94e-01 | 0.1149 |
1104 | RCC1 | P16T-E | Human | Esophagus | ESCC | 3.81e-18 | 4.84e-01 | 0.1153 |
1104 | RCC1 | P17T-E | Human | Esophagus | ESCC | 2.92e-15 | 7.90e-01 | 0.1278 |
1104 | RCC1 | P19T-E | Human | Esophagus | ESCC | 4.29e-07 | 1.00e+00 | 0.1662 |
1104 | RCC1 | P20T-E | Human | Esophagus | ESCC | 1.58e-41 | 1.19e+00 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:190336210 | Cervix | CC | regulation of cellular protein catabolic process | 72/2311 | 255/18723 | 5.98e-12 | 2.10e-09 | 72 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:190305010 | Cervix | CC | regulation of proteolysis involved in cellular protein catabolic process | 60/2311 | 221/18723 | 1.82e-09 | 1.98e-07 | 60 |
GO:200005810 | Cervix | CC | regulation of ubiquitin-dependent protein catabolic process | 47/2311 | 164/18723 | 1.63e-08 | 1.25e-06 | 47 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:004586110 | Cervix | CC | negative regulation of proteolysis | 80/2311 | 351/18723 | 2.88e-08 | 1.98e-06 | 80 |
GO:003133010 | Cervix | CC | negative regulation of cellular catabolic process | 63/2311 | 262/18723 | 1.10e-07 | 5.68e-06 | 63 |
GO:006113610 | Cervix | CC | regulation of proteasomal protein catabolic process | 48/2311 | 187/18723 | 4.63e-07 | 1.77e-05 | 48 |
GO:003243410 | Cervix | CC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 38/2311 | 134/18723 | 4.99e-07 | 1.88e-05 | 38 |
GO:00614588 | Cervix | CC | reproductive system development | 87/2311 | 427/18723 | 1.37e-06 | 4.55e-05 | 87 |
GO:00486088 | Cervix | CC | reproductive structure development | 86/2311 | 424/18723 | 1.90e-06 | 5.97e-05 | 86 |
GO:000989510 | Cervix | CC | negative regulation of catabolic process | 69/2311 | 320/18723 | 2.15e-06 | 6.55e-05 | 69 |
GO:19033639 | Cervix | CC | negative regulation of cellular protein catabolic process | 24/2311 | 75/18723 | 6.43e-06 | 1.55e-04 | 24 |
GO:19016538 | Cervix | CC | cellular response to peptide | 72/2311 | 359/18723 | 1.89e-05 | 3.48e-04 | 72 |
GO:004873210 | Cervix | CC | gland development | 84/2311 | 436/18723 | 1.93e-05 | 3.54e-04 | 84 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:19030519 | Cervix | CC | negative regulation of proteolysis involved in cellular protein catabolic process | 20/2311 | 64/18723 | 5.44e-05 | 8.04e-04 | 20 |
GO:002241110 | Cervix | CC | cellular component disassembly | 83/2311 | 443/18723 | 6.04e-05 | 8.68e-04 | 83 |
GO:004217710 | Cervix | CC | negative regulation of protein catabolic process | 30/2311 | 121/18723 | 1.23e-04 | 1.53e-03 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RCC1 | deletion | Frame_Shift_Del | c.32delN | p.Pro13GlnfsTer11 | p.P13Qfs*11 | P18754 | protein_coding | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
RCC1 | SNV | Missense_Mutation | rs547058163 | c.1090N>A | p.Glu364Lys | p.E364K | P18754 | protein_coding | tolerated(0.19) | benign(0.009) | TCGA-CC-5264-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
RCC1 | SNV | Missense_Mutation | novel | c.1031N>A | p.Gly344Glu | p.G344E | P18754 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DD-AAD5-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RCC1 | SNV | Missense_Mutation | c.743G>C | p.Arg248Pro | p.R248P | P18754 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-G3-A3CK-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RCC1 | SNV | Missense_Mutation | c.1345N>G | p.Lys449Glu | p.K449E | P18754 | protein_coding | deleterious(0.03) | benign(0.019) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
RCC1 | SNV | Missense_Mutation | novel | c.1269G>T | p.Met423Ile | p.M423I | P18754 | protein_coding | tolerated(0.11) | benign(0) | TCGA-05-4390-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
RCC1 | SNV | Missense_Mutation | c.706N>T | p.Gly236Cys | p.G236C | P18754 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
RCC1 | SNV | Missense_Mutation | c.805N>T | p.Gly269Cys | p.G269C | P18754 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-75-5126-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | SD | |
RCC1 | SNV | Missense_Mutation | novel | c.1301N>A | p.Ser434Tyr | p.S434Y | P18754 | protein_coding | tolerated(0.06) | benign(0.34) | TCGA-BA-6871-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RCC1 | SNV | Missense_Mutation | c.544N>T | p.Gly182Cys | p.G182C | P18754 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CV-7238-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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