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Gene: RBM19 |
Gene summary for RBM19 |
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Gene information | Species | Human | Gene symbol | RBM19 | Gene ID | 9904 |
Gene name | RNA binding motif protein 19 | |
Gene Alias | Mrd1 | |
Cytomap | 12q24.13-q24.21 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q9Y4C8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9904 | RBM19 | LZE2T | Human | Esophagus | ESCC | 1.45e-05 | 3.81e-01 | 0.082 |
9904 | RBM19 | LZE4T | Human | Esophagus | ESCC | 4.89e-22 | 6.10e-01 | 0.0811 |
9904 | RBM19 | LZE7T | Human | Esophagus | ESCC | 1.66e-10 | 3.81e-01 | 0.0667 |
9904 | RBM19 | LZE8T | Human | Esophagus | ESCC | 5.20e-08 | 2.31e-01 | 0.067 |
9904 | RBM19 | LZE20T | Human | Esophagus | ESCC | 4.59e-02 | 6.17e-02 | 0.0662 |
9904 | RBM19 | LZE24T | Human | Esophagus | ESCC | 3.50e-05 | 1.01e-01 | 0.0596 |
9904 | RBM19 | P1T-E | Human | Esophagus | ESCC | 5.65e-07 | 1.88e-01 | 0.0875 |
9904 | RBM19 | P2T-E | Human | Esophagus | ESCC | 3.31e-30 | 5.81e-01 | 0.1177 |
9904 | RBM19 | P4T-E | Human | Esophagus | ESCC | 1.42e-14 | 1.62e-01 | 0.1323 |
9904 | RBM19 | P5T-E | Human | Esophagus | ESCC | 4.43e-12 | 1.78e-01 | 0.1327 |
9904 | RBM19 | P8T-E | Human | Esophagus | ESCC | 6.05e-14 | 1.12e-01 | 0.0889 |
9904 | RBM19 | P9T-E | Human | Esophagus | ESCC | 1.45e-10 | 2.86e-01 | 0.1131 |
9904 | RBM19 | P10T-E | Human | Esophagus | ESCC | 9.77e-08 | 7.07e-02 | 0.116 |
9904 | RBM19 | P11T-E | Human | Esophagus | ESCC | 4.61e-09 | 2.87e-01 | 0.1426 |
9904 | RBM19 | P12T-E | Human | Esophagus | ESCC | 5.02e-12 | 2.03e-01 | 0.1122 |
9904 | RBM19 | P15T-E | Human | Esophagus | ESCC | 5.88e-27 | 4.46e-01 | 0.1149 |
9904 | RBM19 | P16T-E | Human | Esophagus | ESCC | 5.29e-23 | 2.53e-01 | 0.1153 |
9904 | RBM19 | P17T-E | Human | Esophagus | ESCC | 5.62e-05 | 2.95e-01 | 0.1278 |
9904 | RBM19 | P19T-E | Human | Esophagus | ESCC | 3.03e-02 | 2.15e-01 | 0.1662 |
9904 | RBM19 | P20T-E | Human | Esophagus | ESCC | 3.85e-11 | 2.27e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000039822 | Liver | HCC | mRNA splicing, via spliceosome | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:000037519 | Oral cavity | OSCC | RNA splicing, via transesterification reactions | 225/7305 | 324/18723 | 5.20e-29 | 2.99e-26 | 225 |
GO:000037719 | Oral cavity | OSCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:000039819 | Oral cavity | OSCC | mRNA splicing, via spliceosome | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:0008380110 | Oral cavity | LP | RNA splicing | 237/4623 | 434/18723 | 1.82e-41 | 3.79e-38 | 237 |
GO:0000375110 | Oral cavity | LP | RNA splicing, via transesterification reactions | 181/4623 | 324/18723 | 1.36e-33 | 1.70e-30 | 181 |
GO:0000377110 | Oral cavity | LP | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
GO:0000398110 | Oral cavity | LP | mRNA splicing, via spliceosome | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
GO:0008380113 | Thyroid | PTC | RNA splicing | 273/5968 | 434/18723 | 4.44e-41 | 1.40e-37 | 273 |
GO:0000375113 | Thyroid | PTC | RNA splicing, via transesterification reactions | 202/5968 | 324/18723 | 6.81e-30 | 3.91e-27 | 202 |
GO:0000377113 | Thyroid | PTC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
GO:0000398113 | Thyroid | PTC | mRNA splicing, via spliceosome | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBM19 | SNV | Missense_Mutation | novel | c.2570N>G | p.Glu857Gly | p.E857G | Q9Y4C8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RBM19 | SNV | Missense_Mutation | novel | c.2186N>T | p.Gly729Val | p.G729V | Q9Y4C8 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RBM19 | SNV | Missense_Mutation | rs777884289 | c.1198N>A | p.Glu400Lys | p.E400K | Q9Y4C8 | protein_coding | deleterious(0.01) | possibly_damaging(0.626) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RBM19 | SNV | Missense_Mutation | rs144857109 | c.586N>A | p.Glu196Lys | p.E196K | Q9Y4C8 | protein_coding | tolerated(0.28) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RBM19 | SNV | Missense_Mutation | rs200306327 | c.1576N>A | p.Asp526Asn | p.D526N | Q9Y4C8 | protein_coding | deleterious(0) | possibly_damaging(0.581) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
RBM19 | SNV | Missense_Mutation | rs866674770 | c.250G>A | p.Ala84Thr | p.A84T | Q9Y4C8 | protein_coding | tolerated(1) | benign(0) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RBM19 | SNV | Missense_Mutation | c.119N>C | p.Lys40Thr | p.K40T | Q9Y4C8 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RBM19 | SNV | Missense_Mutation | novel | c.93C>G | p.Cys31Trp | p.C31W | Q9Y4C8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RBM19 | SNV | Missense_Mutation | c.1372N>C | p.Lys458Gln | p.K458Q | Q9Y4C8 | protein_coding | tolerated(0.11) | benign(0.411) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RBM19 | deletion | Frame_Shift_Del | c.2520delN | p.Phe841SerfsTer18 | p.F841Sfs*18 | Q9Y4C8 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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